Antimicrobial activity of copper against organisms in aqueous solution: A case for copper-based water pipelines in hospitals?

Cervantes, Hilda I.; Álvarez, José Antonio; Muñoz, Juan Manuel; Arreguín, Virginia; Mosqueda, Juan L.; Macías, Alejandro E.

doi:10.1016/j.ajic.2013.03.309

Cited by 14 publications

(11 citation statements)

References 15 publications

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“…28 Similarly, >10 7 cfu of five clinical isolates of methicillin-resistant bacteria were killed in 60-270 min, and in another study, >99% of ten clinical isolates were all killed in 2 h in wet plating on copper. 29,30 We here chose E. coli as the model organism because it has been used in many fundamental studies on contact killing. We also use neutral Na-HEPES buffer, which exhibits the least interference with the copper system.…”

Section: A Contact Killing By Coppermentioning

confidence: 99%

Killing of bacteria by copper, cadmium, and silver surfaces reveals relevant physicochemical parameters

Luo¹,

Hein²,

Mücklich³

et al. 2017

Biointerphases

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The killing of bacteria on metallic copper surfaces in minutes to hours is referred to as contact killing. Why copper possesses such strong antimicrobial activity has remained enigmatic. Based on the physicochemical properties of metals, it was recently predicted that cadmium should also be active in contact killing [Hans et al., Biointerphases 11, 018902 (2010)]. Here, the authors show that cadmium is indeed antimicrobial. It kills three logs of bacteria in 9 h, compared to copper which kills eight logs of bacteria. Metallic silver kills less than one log of bacteria in 9 h. These findings support the novel concept whereby oxide formation, metal ion dissolution, and a Pearson soft character are the key factors for a metal to be antibacterial. Based on these parameters, copper and cadmium are expected to be the two most antibacterial metals.

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Section: A Contact Killing By Coppermentioning

confidence: 99%

Killing of bacteria by copper, cadmium, and silver surfaces reveals relevant physicochemical parameters

Luo¹,

Hein²,

Mücklich³

et al. 2017

Biointerphases

View full text Add to dashboard Cite

show abstract

“…The higher antimicrobial activity reported for wet surfaces may lead to an overestimation of the bactericidal properties of the surface. For this reason, numerous studies have been focused on developing new tests at similar conditions as those detected in real conditions in hospitals [26,27,28,29,30,31]. …”

Section: Factors Responsible For Antimicrobial Behaviourmentioning

confidence: 99%

“…Cervantes et al [31] tried to assess the bactericidal effect of three common plumbing materials (PVC, copper and Pyrex control) in aqueous solution. Several pathogen suspensions (including S. aureus , P. aeruginosa , E. faecalis , and E. coli ) were studied at high and low inoculum densities in pipes of around 3.5 cm diameter, thus a very small proportion of the bacteria are in direct contact with the pipe surfaces.…”

Section: Factors Responsible For Antimicrobial Behaviourmentioning

confidence: 99%

Antibacterial Metallic Touch Surfaces

et al. 2016

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Our aim is to present a comprehensive review of the development of modern antibacterial metallic materials as touch surfaces in healthcare settings. Initially we compare Japanese, European and US standards for the assessment of antimicrobial activity. The variations in methodologies defined in these standards are highlighted. Our review will also cover the most relevant factors that define the antimicrobial performance of metals, namely, the effect of humidity, material geometry, chemistry, physical properties and oxidation of the material. The state of the art in contact-killing materials will be described. Finally, the effect of cleaning products, including disinfectants, on the antimicrobial performance, either by direct contact or by altering the touch surface chemistry on which the microbes attach, will be discussed. We offer our outlook, identifying research areas that require further development and an overview of potential future directions of this exciting field.

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“…According to our results, 99 % copper exhibited the highest reduction of microorganisms and the significance was particularly apparent at 0, 2, and 4 h time intervals. The bactericidal effect of 99 % copper was shorter than the other studies that have evaluated multidrug-resistant bacteria [2,7,22,23]. Two separate studies, Warnes and Keevil [26] and Santo et al [20], recently published that killing of bacteria on a dry copper surface can be as short as 2-10 min.…”

Section: Discussionmentioning

confidence: 98%

Antimicrobial Activity of Copper Alloys Against Invasive Multidrug-Resistant Nosocomial Pathogens

2015

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The emergence and spread of antibiotic resistance demanded novel approaches for the prevention of nosocomial infections, and metallic copper surfaces have been suggested as an alternative for the control of multidrug-resistant (MDR) bacteria in surfaces in the hospital environment. This study aimed to evaluate the antimicrobial activity of copper material for invasive MDR nosocomial pathogens isolated over time, in comparison to stainless steel. Clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) (n:4), OXA-23 and OXA-58 positive, MDR Acinetobacter baumannii (n:6) and Pseudomonas aeruginosa (n:4) were evaluated. The antimicrobial activity of coupons containing 99 % copper and a brass alloy containing 63 % copper was assessed against stainless steel. All the materials demonstrated statistically significant differences within each other for the logarithmic reduction of microorganisms. Among the three materials, the highest reduction of microorganisms was seen in 99 % copper and the least in stainless steel. The result was statistically significant especially for 0, 2, and 4 h (P = 0.05). 99 % copper showed a bactericidal effect at less than 1 h for MRSA and at 2 h for P. aeruginosa. 63 % copper showed a bactericidal effect at 24 h for P. aeruginosa strains only. Stainless steel surfaces exhibited a bacteriostatic effect after 6 h for P. aeruginosa strains only. 99 % copper reduced the number of bacteria used significantly, produced a bactericidal effect and was more effective than 63 % copper. The use of metallic copper material could aid in reducing the concentration of bacteria, especially for invasive nosocomial pathogens on hard surfaces in the hospital environment.

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Antimicrobial activity of copper against organisms in aqueous solution: A case for copper-based water pipelines in hospitals?

Cited by 14 publications

References 15 publications

Killing of bacteria by copper, cadmium, and silver surfaces reveals relevant physicochemical parameters

Killing of bacteria by copper, cadmium, and silver surfaces reveals relevant physicochemical parameters

Antibacterial Metallic Touch Surfaces

Antimicrobial Activity of Copper Alloys Against Invasive Multidrug-Resistant Nosocomial Pathogens

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