Antimicrobial Activity of Basidiomycetes

Medicinal and edible lignicolous fungi as natural sources of antioxidative and antibacterial agents

“…The high phenolic acid content (gallic and protochatecuic) of L. sulphureus, P. tigrinus and P. ostreatus suggests that such compounds are not involved in this effect, unlike F. velutipes and M. giganteus. Coriolin, a sesquiterpene from Coriolus species, inhibits Gram-positive bacteria (Smania et al, 2001) while Ganoderma species contain triterpenoids (Shiao, 1992) and ganomycins that inhibit the growth of methicillin-resistant S. aureus and other bacteria including E. coli and Pseudomonas aeruginosa (Mothana et al, 2000;Ofodile et al, 2005). F. velutipes contains enokipodins (Ishikawa et al, 2005).…”

“…Other, non-phenolic, compounds including terpenoids (Leon et al, 2004) and polysaccharides (Tseng et al, 2008) have also been designated as mushroom antioxidants. Most previous studies of fungal antioxidants have been oriented towards commercial mushrooms used as food (Dubost et al, 2007), but the recent scientifi c literature shows an even higher antioxidative potential for wild-growing edible mushrooms (Barros et al, 2007(Barros et al, , 2008Elmastas et al, 2007).As potential new sources of natural antibiotics, lignicolous fungal extracts have also been investigated (Smania et al, 2001;Turkoglu et al, 2007), and chloroform extracts of Lentinus edodes have been shown to possess bactericidal activities (Hirasawa et al, 1999).The mycological potential (both gastronomic and economic) of Serbia is attributable to favourable climatic conditions and fl oral diversity, whilst the lack of data on the bioactive properties of wild-growing autochthonous fungal species has increased our interest in these properties. The aim of this work was to study the antioxidant and antimicrobial properties of some edible and medicinal fungal species collected from northern Serbia, in the Fruska Gora low mountain chain.…”

Antibacterial Agents from Lignicolous Macrofungi

“…As potential new sources of natural antibiotics, lignicolous mushrooms again become the subject of study (Smania et al, 2001). The fact that humans and animals share common microbial pathogens with fungi (E. coli, S. aureus and P. areuginosa) has prompted the thought that they produce compounds that may have similar effects in humans (Zjawioni, 2004).…”

New bioactive natural products fromCoprinus micaceus

“…Mushrooms are one of the major sources of natural products exhibiting bioactivities including anti-microbial and anti-viral activities [1][2][3][4]. Coprinus micaceus is abundant in the prairie region of Canada and is an edible mushroom.…”

“…In our continuing effort to discover bioactive natural products, we found that the methanolic extract of C. micaceus exhibited antibacterial activity against Enterococcus faecalis, Staphylococcus aureus, Corynebacterium xerosis and Escherichia coli at the concentration of 250 mg mL À1 in a preliminary anti-bacterial screening assay. Bioassay guided fractionation of methanolic extract of this mushroom subsequently resulted in the isolation of a new bioactive sterol, micaceol (1) and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2). Spectroscopic methods were used to establish the structures of these compounds.…”