Antibacterial Agents from Lignicolous Macrofungi

Karaman, Maja; Matavulj, M.; Janjic, Ljiljana

doi:10.5772/33919

Cited by 5 publications

(8 citation statements)

References 101 publications

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“…H 2 O extracts of G. applanatum from India exhibited similar AB susceptibility against S. aureus (inhibition zone 12 mm) and no activity against P. aeruginosa , while higher activity was observed against E. coli [ 34 ]. Different activities obtained by Karaman et al [ 13 ] on different strains of S. aureus , demonstrated that the fungal extracts were target-specific at the intraspecies level, which is also in accordance with the results of this study. G. pfeifferi exhibited the highest AB susceptibility against E. coli (21 mm), which is in accordance with the report [ 19 ]; among Gram-negative bacteria, E. coli was the most affected by volatile oil isolated from this fungus (15 mm).…”

Section: Resultssupporting

confidence: 93%

“…Despite wide distribution, just a few species, mainly from G. lucidum complex (currently thirteen well-delineated species recognized in this group, including G. resinaceum ), were used in traditional Chinese Medicine (TCM) for over two millennia and over the last few decades it has gained a lot of interest in Western medicine [ 9 ]. In addition to its well-studied anticancer, antioxidative, hepatoprotective and immunomodulatory activities [ 10 ], various Ganoderma extracts have also been found to have antibacterial (AB) activity [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ], as well as antifungal (AF) [ 18 , 19 ] and antiviral (AV) [ 20 , 21 ] properties. The presence of phenolic compounds was linked to the AB activity of extracts from G. lucidum [ 12 , 22 , 23 ] and G. resinaceum [ 24 ], while terpenoids from G. applanatum have been connected to the antioxidant (AO) and antimicrobial (AM) activities [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?

et al. 2023

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Ganoderma species have been recognized as potential antimicrobial (AM) agents and have been used in traditional Chinese medicine (TCM) for a long time. The aim of this study is to examine the AM potential of autochthonous Ganoderma species (G. applanatum, G. lucidum, G. pfeifferi and G. resinaceum) from Serbia. The extraction of fungal material was prepared in different solvents (ethanol—EtOH, water—H2O, chloroform—CHCl3). Antibacterial activity (ABA) was determined using disk-diffusion, agar-well diffusion, and micro-dilution method, while for antifungal properties disk-diffusion and pour plate method were applied. Antiviral activity was tested on model DNA virus LK3 and determined by plaque assay. Statistical PCA analysis was applied for detection of correlation effects of phenolics and AM activities, while LC-MS/MS was performed for phenolics quantification. G. resinaceum CHCl3 extract expressed the most potent ABA against P. aeruginosa (MIC = 6.25 mg/mL), probably due to presence of flavonoids and 2,5-dihydroxybenzoic acid. Among H2O extracts, the highest ABA was determined for G. pfeifferi against both E. coli and S. aureus (21 and 19 mm, respectively). EtOH extracts of G. pfeifferi and G. resinaceum were the most effective against A. niger (23.8 and 20.15 mm, respectively), with special impact of phenolic acids and flavonoid isorhamnetin, while C. albicans showed the lowest susceptibility. The most potent antiviral inhibitor was G. lucidum (70.73% growth inhibition) due to the high amount of phenolic acids. To the best of our knowledge, this is the first report of a methodical AM profile of G. pfeifferi and G. resinaceum from the Balkan region including PCA analysis.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?

et al. 2023

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“…Regarding the fact that macrofungi are commonly collected either randomly or by locals in forests, it would be necessary to perform initial screening for possible antimicrobial activities by using crude aqueous or alcohol extractions. Proper selection of the extraction procedure directly determines the antimicrobial activity of the extract [23].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial and antifungal potential of wild basidiomycete mushroom Ganoderma applanatum

Klaus¹,

Kozarski²,

Vunduk³

et al. 2016

Lek sirovine

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Hot water extract (AN), partially purified polysaccharides (AP) and hot alkali extract (ANa) obtained from wild mushroom G. applanatum were examined for their antibacterial and antifungal activity. Five Gram negative (Proteus hauseri, Escherichia coli O157:H7, Salmonella Enteritidis, Shigella sonnei, Yersinia enterocolitica), five Gram positive (Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus, Geobacillus stearothermophyllus, Enterococcus faecalis) bacterial strains, as well as two fungal strains (Candida albicans and Cryptococcus neoformans), all belonging to the American Type Culture Collection (ATCC), were tested by broth microdilution assay. In general, Gram-positive bacteria were more sensitive in the presence of tested extracts than Gram-negative bacterial species. Almost all tested extracts demonstrated a high microbistatic potential, and in most cases the microbicidal effect also has been reached. The best antibacterial effect of hot water alkali extract, ANa, was observed in the case of E. faecalis (MIC 0.039 mg/mL, MBC 1.25 mg/mL), while the same extract was the most effective antifungal agent towards C. neoformans (MIC 0.078 mg/mL, MFC 2.5 mg/mL). This research indicates possibility to use selected extracts, obtained from the mushroom G. applanatum, in order to 38 prevent the development of some pathogenic microorganisms and food spoilage.

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“…Mushrooms actually are mycofactories as they produce variety of secondary metabolites, including phenolic compounds, polyketides, terpenes and steroids (Turkoglu et al, 2007). Numerous bioactive properties of mushrooms, such as antioxidant, antitumor (Ferreira et al, 2010;Puttaraju et al, 2006;Vaz et al, 2012;Wasser, 2002;Zaidman et al, 2005), and antimicrobial activities (Barros et al, 2007, Karaman et al, 2009Karaman et al, 2012;Stojković et al, 2013) were discovered and addressed to abovementioned compounds. It is assumed that the presence of these com-pounds provides protection against certain chronic diseases such as cardiovascular diseases, cancer, diabetes, and neurological disorders (Zhou et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Nutritional and phenolic profile of small edible fungal species Coprinellus disseminatus (pers.) J.E. Lange 1938

Novaković¹,

Karaman²,

Milovanović³

et al. 2018

Food & Feed Res

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The aim of this work was to investigate nutritional profile in relation to proteins, amino acids, fatty acids and mineral composition, as well as phenolic profile of small edible fungal species Coprinellus disseminatus originated from Serbia. Total protein content in the analyzed fungal species was 9.72%. Fifteen protein fractions obtained by electrophoresis were identified in a range from 1.6 to 63.6 kDa. Chip-based separations showed the presence of protein fraction with molecular weight of 27.5 kDa that could possess antifungal activity. The total essential and non-essential amino acid contents were 29.57 and 96.69 mg/g DW, respectively. Among the essential amino acids, leucine was the most abundant. Fatty acid composition of C. disseminatus showed that polyunsaturated fatty acids (PUFA, 59.1% of total FA) predominated over saturated fatty acids (SFA, 23.1% of total FA) and monounsaturated fatty acids (MUFA, 17.9% of total FA). The dominant fatty acids were linoleic acid (56.6%), palmitic acid (13.9%), and oleic acid (12.0%). The most abundant macroelement in C. disseminatus was potassium, followed by calcium and magnesium, while iron dominated in microelements. Eight phenolic compounds were quantified in methanolic extract of C. disseminatus by LC-MS/MS with the highest amount of p-hydroxybenzoic acid and p-coumaric acid reaching 9.46 ± 0.2 µg/g DW and 7.8 ± 0.1 µg/g DW, respectively.

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Antibacterial Agents from Lignicolous Macrofungi

Cited by 5 publications

References 101 publications

Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?

Do Ganoderma Species Represent Novel Sources of Phenolic Based Antimicrobial Agents?

Antibacterial and antifungal potential of wild basidiomycete mushroom Ganoderma applanatum

Nutritional and phenolic profile of small edible fungal species Coprinellus disseminatus (pers.) J.E. Lange 1938

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