New bioactive natural products from<b><i>Coprinus micaceus</i></b>

Zahid, Shamsulhaq; Udenigwe, Chibuike C.; Ata, Athar; Eze, Michael O.; Segstro, Edward P.; Holloway, Paul

doi:10.1080/14786410601101829

Cited by 24 publications

(12 citation statements)

References 19 publications

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“…Coprinelus micaceus is considered conditionally edible given the fact that consumption with alcoholic beverages may produce symptoms such as reddening of the face, increased heart rate, vomiting, malaise, agitation and diarrhoea (Chang and Miles 2004). Nonetheless, the Coprinelus micaceus species contains some of unique bioactive chemical compounds, such as sterol micaceol with a ''modest'' antibacterial activity (Zahid et al 2006). Likewise, the species Coprinus comatus generates 4,5-dihydroxy-2-methyoxy-benzaldehyde, also known as comatin, a compound with a hypoglycaemic effect (Ding et al 2010).…”

Section: Introductionmentioning

confidence: 99%

A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum

et al. 2017

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Bioactive properties of fungi considerably differ between the fruiting body (FB) and the submerged culture as regards mycelia (M) and the fermentation broth (F). Antioxidant properties of hot-water extracts obtained from three different fungal origins: FB, M and F of two autochthonous fungal species (Northern Serbia), Coprinus comatus and Coprinellus truncorum were investigated. Free radical scavenging capacity (RSC) was evaluated in vitro by the DPPH assay and reducing power ability (FRAP assay). Considering possible bioactive properties of different compounds present in fungal extracts, the content of total proteins (TP), phenols (TC) and flavonoids (TF) were investigated colorimetrically. The chemical characterisation of the examined extracts was evaluated using the HPLC-MS/MS method. C. comatus showed the strongest RSC activity; more precisely, fermentation broth extract (FCc) on DPPH radicals (IC50 = 5.06 lg mL -1 ) and fruiting body extract (FBCc) for the FRAP assay (42.86 mg ascorbic acid equivalents (AAE)/g). Submerged M extract of both species showed the highest TC (MCc 81.95 mg gallic acid eq (GAE)/g d.w.; MCt 81.64 mg GAE/g d.w.), while FB extracts contained the highest content of TP. Comparing LC-MS phenolic profiles between species-interspecifically and among different fungal origins-intraspecifically (fruiting bodies and submerged cultures), high variations were noticed. In submerged M or F extracts of C. comatus, vanillic, gallic, gentisic and cinnamic acids were detected, as opposed to FB. Considering that diverse phenolic profiles of detected antioxidant compounds were obtained by submerged cultivation, this type of cultivation is promising for the production of antioxidant substances.

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Section: Introductionmentioning

confidence: 99%

A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum

et al. 2017

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“…In addition, macrofungi have a widely acknowledged antimicrobial potential and have been documented to possess these activities since the 1940s (Wilkins and Harris, ; Mathieson, ; Robbins et al ., ). Some of the antimicrobials isolated from basidiomycetous macrofungi include grifolin (Hirata and Nakanishi, ), pleuromutilin (Kavanagh et al ., ), striatins A, B and C (Anke and Oberwinkler, ), oudemansin (Anke et al ., ), scorodonin (Anke et al ., ), strobilurin C and oudemansin‐b (Anke et al ., ), ganomycins (Mothana et al ., ) and micaceol (Zahid et al ., ). Among all the antibiotics from basidiomycetes, retapamulin has emerged as an antibiotic of practical significance and has been approved for use by the US Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 97%

Antimicrobial Potential of Australian Macrofungi Extracts Against Foodborne and Other Pathogens

Bala

Aitken

Cusack³

et al. 2011

Phytotherapy Research

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Basidiomycetous macrofungi have therapeutic potential due to antimicrobial activity but little information is available for Australian macrofungi. Therefore, the present study investigated 12 Australian basidiomycetous macrofungi, previously shown to have promising activity against Staphylococcus aureus and Escherichia coli, for their antimicrobial potential against a range of other clinically relevant micro-organisms. Fruiting bodies were collected from across Queensland, Australia, freeze-dried and sequentially extracted with water and ethanol. The crude extracts were tested at 10 mg/mL and 1 mg/mL against six pathogens including two Gram-positive and two Gram-negative bacteria along with two fungi using a high throughput 96-well microplate bioassay. A degree of specificity in activity was exhibited by the water extract of Ramaria sp. (Gomphaceae) and the ethanol extracts of Psathyrella sp. (Psathyrellaceae) and Hohenbuehelia sp., which inhibited the growth of the two fungal pathogens used in the assay. Similarly, the ethanol extract of Fomitopsis lilacinogilva (Fomitopsidaceae) was active against the Gram-positive bacteria B. cereus only. Activity against a wider range of the microorganisms used in the assay was exhibited by the ethanol extract of Ramaria sp. and the water extract of Hohenbuehelia sp. (Pleurotaceae). These macrofungi can serve as new sources for the discovery and development of much needed new antimicrobials.

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“…Mushrooms are well known in terms of their medicinal importance and have long been used in traditional medicines in many parts of the world. Mushrooms are one of the major sources of natural products exhibiting bioactivities including antimicrobial and antiviral activities [1]. Ganoderma lucidium can not be used in daily diet whereas Lentinula edodes and Coprinus micaceus can be used as nutrient because of their medical effects.…”

Section: Introductionmentioning

confidence: 99%

Determination of Antioxidant and Antimicrobial Activities of Medically Important Mushrooms Using Different Solvents and Chemical Composition via GC/MS Analyses

Avcı¹,

Avcı

Köse³

2014

JFNR

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The aim of present work was the determination of antioxidant activities of the ethanol extract from three mushrooms (Ganoderma lucidium, Lentinula edodes and Coprinus micaceus) by using DPPH radical scavenging and total antioxidant status assays. Additionally, in this study, GC/MS analyses and antimicrobial activity assay of three mushrooms were made. Ethanol, chloroform and distilled water used as solvent for preparation of mushrooms extract. Radical scavenging activities and total antioxidant status of three mushrooms extracted in ethanol were measured via spectrophotometric methods. In addition, for chromatographic analysis GC/MS were used. At the same time, diphenic acid and bis(2-ethylhexyl)pthalate derivatives were found the highest in contents of all extracts with GC/MS. The determination of antimicrobial activity of mushrooms extracts against Pseudomonas aeroginosa (ATCC 27853), Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 25923) and Candida albicans (ATCC 10231) was investigated by disc and agar-well diffusion methods. As result, radical scavenging activities and total antioxidant status values of G. lucidium extract were found higher than those of both L. edodes and C. micaceus. All mushrooms used in this study were found to have antimicrobial effects at a variety of degrees against microorganisms tested. Moreover, all extracts together with solvents were analyzed, ethanol and chloroform extracts were found to be more effective for G. lucidum and C. micaceus, and L. edodes than other solvents, respectively.

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New bioactive natural products fromCoprinus micaceus

Cited by 24 publications

References 19 publications

A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum

A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum

Antimicrobial Potential of Australian Macrofungi Extracts Against Foodborne and Other Pathogens

Determination of Antioxidant and Antimicrobial Activities of Medically Important Mushrooms Using Different Solvents and Chemical Composition via GC/MS Analyses

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