Antimicrobial activity of apitoxin from Apis mellifera in Salmonella enterica strains isolated from poultry and its effects on motility, biofilm formation and gene expression

Arteaga, Vicente; Lamas, Alexandre; Regal, Patricia; Vázquez, Beatriz; Miranda, José Manuel; Cepeda, Alberto; Franco, Carlos

doi:10.1016/j.micpath.2019.103771

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…Different works have observed that the main components of apitoxin, such as pure melittin and phospholipase A, have high antimicrobial activity against different bacterial pathogens [15]. However, a very limited number of studies have tested the inhibitory capacity of pure apitoxin in bacteria, and the information available on foodborne pathogens is currently insufficient [22]. The results of this study show significant differences in MIC values between Salmonella (256-1024 µg/mL) and L. monocytogenes (16-32 µg/mL) strains.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Five Apitoxins from Apis mellifera on Two Common Foodborne Pathogens

et al. 2020

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Antimicrobial resistance is one of today’s major public health challenges. Infections caused by multidrug-resistant bacteria have been responsible for an increasing number of deaths in recent decades. These resistant bacteria are also a concern in the food chain, as bacteria can resist common biocides used in the food industry and reach consumers. As a consequence, the search for alternatives to common antimicrobials by the scientific community has intensified. Substances obtained from nature have shown great potential as new sources of antimicrobial activity. The aim of this study was to evaluate the antimicrobial activity of five bee venoms, also called apitoxins, against two common foodborne pathogens. A total of 50 strains of the Gram-negative pathogen Salmonella enterica and 8 strains of the Gram-positive pathogen Listeria monocytogenes were tested. The results show that the minimum inhibitory concentration (MIC) values were highly influenced by the bacterial genus. The MIC values ranged from 256 to 1024 µg/mL in S. enterica and from 16 to 32 µg/mL in L. monocytogenes. The results of this study demonstrate that apitoxin is a potential alternative agent against common foodborne pathogens, and it can be included in the development of new models to inhibit the growth of pathogenic bacteria in the food chain.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Five Apitoxins from Apis mellifera on Two Common Foodborne Pathogens

et al. 2020

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“…The percentage of biofilm reduction observed ranged from 27.66% (S. Infantis Lhica I17) to 68.22% (Salmonella enterica subsp. salamae SA3), with significant variability among the different Salmonella strains tested [42].…”

Section: Antibacterialmentioning

confidence: 98%

Antimicrobial Properties of Apis mellifera’s Bee Venom

El-Seedi

El-Wahed

Yosri

et al. 2020

Toxins

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Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis mellifera L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom’s observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.

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“…In 14 of the 16 tested strains, apitoxin reduced the biofilm formation and destroyed the preformed biofilm by 47%. Also, apitoxin increased the mobility of the bacteria and the MIC varied between 1024-256 µg/mL [7]. Aiming to find an alternative to antibiotics in the poultry industry, broiler chicks were sprayed with BV to evaluate its immunoprophylactic effects against Salmonella gallinarum.…”

Section: Antibacterial Activity Of Bee Venommentioning

confidence: 99%

“…As for the BV, despite its possible adverse effects like the allergic reactions that might occur after the bee sting, one cannot disregard its various therapeutic effects. BV exerts anticancer, antiviral, antifungal and antibacterial effects, it is also used for the treatment of many neurodegenerative diseases [6][7][8][9][10]. Regarding propolis, it has the capacity to fight against cancer and many microorganisms [4,11,12].…”

Section: Introductionmentioning

confidence: 99%

Beehive Products as Antibacterial Agents: A Review

et al. 2021

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Honeybees are one of the most marvelous and economically beneficial insects. As pollinators, they play a vital role in every aspect of the ecosystem. Beehive products have been used for thousands of years in many cultures for the treatment of various diseases. Their healing properties have been documented in many religious texts like the Noble Quran and the Holy Bible. Honey, bee venom, propolis, pollen and royal jelly all demonstrated a richness in their bioactive compounds which make them effective against a variety of bacterial strains. Furthermore, many studies showed that honey and bee venom work as powerful antibacterial agents against a wide range of bacteria including life-threatening bacteria. Several reports documented the biological activities of honeybee products but none of them emphasized on the antibacterial activity of all beehive products. Therefore, this review aims to highlight the antibacterial activity of honey, bee venom, propolis, pollen and royal jelly, that are produced by honeybees.

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Antimicrobial activity of apitoxin from Apis mellifera in Salmonella enterica strains isolated from poultry and its effects on motility, biofilm formation and gene expression

Cited by 17 publications

References 38 publications

Antimicrobial Activity of Five Apitoxins from Apis mellifera on Two Common Foodborne Pathogens

Antimicrobial Activity of Five Apitoxins from Apis mellifera on Two Common Foodborne Pathogens

Antimicrobial Properties of Apis mellifera’s Bee Venom

Beehive Products as Antibacterial Agents: A Review

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