Antimelanogenic and Antimigration Properties of the Ethyl Acetate Fraction of <i>Calendula officinalis</i> Flowers on Melanoma Cells

Xuan, Song Hua; Park, Young Min; Park, Soo Nam

doi:10.1111/php.13064

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Additionally, the activity and expression of matrix metalloproteinase 2 (MMP-2) were significantly inhibited via suppression of the mitogen-activated protein kinase (MAPK) signalling pathway. 45 Interestingly, in our recent study, extracts of flowers, leaves and even roots from C officinalis obtained by different methods of extraction (homogenizer-assisted, maceration, soxhlet and ultrasound-assisted extraction) were found to be active inhibitors of the enzymes studied herein. 27 Molecular docking has become an increasingly essential tool for drug discovery.…”

Section: Ta B L E 2 (Continued)mentioning

confidence: 62%

“…In contrast to the present study which showed C officinalis essential oils to inhibit tyrosinase involved in melanin production, others by other methods showed that ethyl acetate fraction of C officinalis flower to markedly decrease α‐MSH‐induced melanin production and the cell migration ability of melanoma cells in a dose‐dependent way. Additionally, the activity and expression of matrix metalloproteinase 2 (MMP‐2) were significantly inhibited via suppression of the mitogen‐activated protein kinase (MAPK) signalling pathway 45 . Interestingly, in our recent study, extracts of flowers, leaves and even roots from C officinalis obtained by different methods of extraction (homogenizer‐assisted, maceration, soxhlet and ultrasound‐assisted extraction) were found to be active inhibitors of the enzymes studied herein 27 …”

Section: Resultsmentioning

confidence: 92%

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Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Zengin

Ceylan

et al. 2021

Flavour & Fragrance J

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Calendula officinalis L., commonly known as pot marigold, is a popular ornamental and highly medicinal plant. In fact, it is well recognized for its wide‐ranging therapeutic effects conducive to wound healing and for treating various illnesses. In this study, the essential oils from flowers and leaves of C. officinalis were analysed for their chemical constituents and screened for their in vitro antioxidant and enzyme inhibitory properties. Thirty compounds were found in common in both essential oils, with the sesquiterpene alcohol, α‐cadinol as the most abundant compound (leaf: 32.3% and flower: 31.3%, respectively). Besides, the essential oils were found to possess antioxidant capacity through free radical scavenging and reducing mechanisms (DPPH: 2.94, 1.52 mg trolox equivalent (TE)/g of oil; ABTS: 20.72, 2.86 mg TE/g; CUPRAC: 31.16, 47.98 mg TE/g; FRAP: 24.84, 23.42 mg TE/g; phosphomolybdenum: 4.01, 4.68 mmol TE/g for leaves and flowers essential oils, respectively). Moreover, the essential oils (leaves and flowers, respectively) were found to inhibit all the tested enzymes, namely amylase (0.46, 0.42 mmol acarbose equivalent (ACAE)/g), glucosidase (1.35, 1.31 mmol ACAE/g), acetylcholinesterase (2.48, 2.36 mg galantamine (GALAE)/g) and butyrylcholinesterase (8.13, 8.20 mg GALAE/g) and tyrosinase (47.73, 54.36 mg kojic acid equivalent/g). Molecular docking was also performed revealing the compounds neophytadiene and α‐humulene to show the highest binding affinity with tyrosinase. Therefore, the obtained results demonstrated some appealing activities of C officinalis essential oils as natural pharmacological agents that could be valuable for the potential development of phyto‐formulations against the herein targeted diseases and especially for cosmeceutical applications.

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Section: Ta B L E 2 (Continued)mentioning

confidence: 62%

Section: Resultsmentioning

confidence: 92%

Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Zengin

Ceylan

et al. 2021

Flavour & Fragrance J

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“…Natural products are resources to find depigmenting agents with antimelanogenic properties. Plant extracts that have been suggested to possess antimelanogenic activity include Alnus cordata stem bark extract, Momordica charantia methanol extract, and the ethyl acetate fraction of Calendula officinalis flowers [11][12][13]. Single compounds isolated from natural sources are also candidates to replace arbutin and kojic acid in efficacy comparison studies.…”

Section: Introductionmentioning

confidence: 99%

Antimelanogenic activities of piperlongumine derived from Piper longum on murine B16F10 melanoma cells in vitro and zebrafish embryos in vivo: its molecular mode of depigmenting action

Jeon

Kim

et al. 2019

Appl Biol Chem

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In this study, the antimelanogenic activity of piperlongumine in murine B16F10 melanoma cells and zebrafish was investigated, and its mode of antimelanogenic action was elucidated using quantitative reverse transcription-polymerase chain reaction. A melanocyte-stimulating hormone (α-MSH, 200 nM) was used to induce melanin production in B16F10 melanoma cells, and kojic acid (200 μM) was used as a positive control. Piperlongumine had no inhibitory effects on cell growth at the treated concentrations (3 and 6 μM), and it significantly reduced total melanin production. Piperlongumine decreased the expression of Mitf, Tyr, Trp-1, and Trp-2 and tyrosinase activity was also dramatically reduced by the piper amide addition under α-MSH treatment. With these findings, zebrafish embryos were used to confirm antimelanogenic activity of piperlongumine, and it showed the potent antimelanogenic activity at the concentration of 1 μM. Altogether, piperlongumine has potent antimelanogenic activity, and these results support it as a candidate for natural depigmentation agent in a cosmetic and pharmaceutical industries.

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The effects and underlying mechanisms of medicine and food homologous flowers on the prevention and treatment of related diseases

Zou

Zhang³

et al. 2022

Journal of Food Biochemistry

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The theory of medicine and food homology has a long history in China. Numerous traditional Chinese medicinal could be used as both medicine and food. Many flower medicinal materials also belong to the homology of medicine and food, such as Chrysanthemum morifolium, Lonicera japonica, Crocus sativus, and Lonicera macranthoides. They mainly contain flavonoids, organic acids, terpenoids, and other active ingredients, which have a variety of medicinal values, including anti‐inflammatory, anti‐tumor, and antioxidant. There are many formulations and functional foods containing these plants in Chinese medicine, which have a variety of nutritional and health effects on the human body. In this review, 10 widely used flowers were selected to review their pharmacological activities, prevention and treatment of related diseases and underlying mechanisms, and discussed the current limitations and future development prospects, hoping to provide references for the research on the development and utilization of natural medical flowers. Practical applications The “homology of medicine and food” flowers have a wide range of uses and are of great research value. In this paper, we introduce 10 “homology of medicine and food” flowers. Their active ingredients, pharmacological activities, and treatments for related diseases are reviewed, and the limitations and development prospects of the “homology of medicine and food” flowers are discussed. It is hoped that this will contribute to the development of the food and pharmacological fields.

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Antimelanogenic and Antimigration Properties of the Ethyl Acetate Fraction of Calendula officinalis Flowers on Melanoma Cells

Cited by 3 publications

References 31 publications

Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Antimelanogenic activities of piperlongumine derived from Piper longum on murine B16F10 melanoma cells in vitro and zebrafish embryos in vivo: its molecular mode of depigmenting action

The effects and underlying mechanisms of medicine and food homologous flowers on the prevention and treatment of related diseases

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