Antimalarial activity of <i>Swartzia madagascariensis</i> desv. (leguminosae), <i>Combretum glutinosum</i> guill. & perr. (combretaceae) and <i>Tinospora bakis</i> miers. (menispermaceae), Burkina Faso medicinal plants

Abstract

Swartzia madagascariensis, Combretum glutinosum and Tinospora bakis are three plants of the folk medicine used by healers in Burkina Faso for the treatment of malaria. A scientific validation of this utilization was not previously made. Aqueous, methanol, hydromethanol extracts from the roots bark of S. madagascariensis, methanol and hydromethanol extracts from the leaves of C. glutinosum and aqueous and alkaloidal extracts from the roots of T. bakis were also made and their antimalarial activity was screened against Plasmodium falciparum chloroquine-resistant strain W2 in vitro. The screening showed that the methanol and hydromethanol extracts of Swartzia madagascariensis, hydromethanol extracts of Combretum glutinosum and alkaloidal extracts of Tinospora bakis were active (5µg/ml < IC50 < 50 µg/ml).

In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum

“…The plant extracts were dissolved in dimethyl sulphoxide (HiMedia Laboratories Private Limited, Mumbai, India) and filtered through Millipore sterile filters (mesh 0.20 μm, Sartorious Stedim Biotech GmbH, Germany). The filatrate was used for testing at different concentrations of 200, 100, 50, 25, 12.5, 6.25, and 3.125 μg.ml −1 (Ouattara et al 2006). …”

Mangrove plants as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India

“…The plant extracts were dissolved in dimethyl sulphoxide (HiMedia Laboratories Private Limited, Mumbai, India) and filtered through Millipore sterile filters (mesh 0.20 μm, Sartorious Stedim Biotech GmbH, Germany). The filtrates were used for testing at different concentrations of 100, 50, 25, 12.5, 6.25, and 3.125 μg.ml −1 (Ouattara et al 2006). …”

Traditional Medicinal Plants and Malaria in Africa

“…Swartzia madagascariensis, Combretum glutinosum and Tinospora bakis are three plants of the folk medicine used by healers in Burkina Faso for the treatment of malaria (6). Cameroon healers used the boiling water extraction of stem bark and seeds of four medicinal plants, Entandrophragma angolens, Picaralima nitida, Schumanniophyton magnificum and Thomandersia hensii against malaria and report good results (14).…”

“…The evidence for effectiveness of traditional medicinal plants in the treatment of infections is quite different from that, for example, of modern antibiotics. Traditional healers have for decades used many plants throughout African countries, to treat malaria, the symptoms of malaria as well as a wide range of deseases (5)(6).…”