Antimalarial Activity of Andrographis paniculata (Kalmegh) against Plasmodium berghei NK 65 in Mastomys natalensis

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

“…Andrographis paniculata was found to considerably inhibit the multiplication of Plasmodium berghei. 15) The protective action of Andrographis paniculata is proposed to be due to reactivation of the key antioxidant enzyme superoxide dismutase. 20) In dog, Andrographis paniculata extracts effectively killed filaria that obstructed lymph channels, consequently leading to elephantiasis.…”

“…5) In Thailand, this plant was selected by the Ministry of Public Health as one of the medicinal plants to be included in "The National List of Essential Drugs A.D. 1999" (List of Herbal Medicinal Products). 6) Extensive research has revealed that Andrographis paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial, such as antiinflammatory, [7][8][9][10][11] antidiarrhoeal, 12,13) antiviral, 14) anti-malarial, 15,16) hepatoprotective, [17][18][19][20][21][22][23][24][25][26][27][28][29] cardiovascular, 30,31) anticancer, [32][33][34][35][36][37][38][39] and immunostimulatory [40][41][42][43][44] activities. On the other hand, male reproductive toxicity 45) and cytotoxicity 46) of this plant have been reported as well.…”

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

“…Extensive 46 research revealed that A. paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial and include anticancer (Kumar et al, 2004), anti HIV (Chang andYeung, 1988), anti AIDS (Stephen and Comac, 2000), hepatoprotective (Handa and Sharma, 1990) and immunostimulatory (Puri et al, 1993). Other pharmacological effects include; antimalarial (Misra et al, 1992), antityphoid (Sabu, 2006), antiviral (Wiart et al, 2005), antifungal (Sabu, 2006), antibacterial (Mishra et al, 2009), antidiarrhoeal (Gupta et al, 1993), antipyretic (Vedavathy andRao, 1991), antiinflammatory (Chang andBut, 1986), antidiabetic (Zhang and Tan, 2000), antithrombotic (Yeung et al, 1987), cardiovascular Zhang, 2004), antivenom (Chang andBut, 1986), antifertility (Sakila et al, 2009) and psychopharmacological activity (Mandal et al, 2001). A. paniculata may be a promising treatment for the alleviation of subjective symptoms of respiratory tract infections (Coon and Ernst, 2004).…”

Variation of Andrographolide Content in Andrographis paniculata from Different Sites of Balaghat Region of Jabalpur (M.P.)

“…Whole plant has variety of therapeutic uses. Phytochemical data revealed that this plant can be used for the treatment of common cold pharyngotonsillitis and diarrhea (Mishra et al 1992 andNajib et al 1999). Antioxidant properties of Andrographis paniculata were recorded by (Trivedi and Raval, 2001).…”