Antilithiatic effect of flowers of<i>Jasminum Auriculatum</i>Vahl

Bahuguna, Yogendr; Rawat, Mahiraj Singh; Juyal, Vijay; Gupta, Vikas

doi:10.4103/0973-8258.54910

Cited by 28 publications

(20 citation statements)

References 15 publications

(19 reference statements)

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“…Assessment of serum creatinine and blood urea nitrogen (BUN) was carried out to test the renal function, and as markers of glomerular and tubular damage (Thamilselvan and Menon, 2005). Results revealed significantly higher levels of creatinine and BUN in the EG/AC treated group when compared with the normal control group (P < 0.001); in agreement with the results of other studies (Jihong et al, 2007;Touhami, 2007;Thamilselvan and Menon, 2005;Al-Attar, 2010;Bahuguna et al, 2009). In nephrolithiasis, the glomerular filtration rate (GFR) is reduced due to obstruction of the urinary outflow with stones; as a result waste products particularly nitrogenous compounds such as creatinine, uric acid and urea accumulate in the blood.…”

Section: Discussionsupporting

confidence: 85%

Effect of Cymbopogon proximus (Mahareb) on ethylene glycol-induced nephrolithiasis in rats

Warrag¹,

Eldin²,

Ahmed³

2014

Afr. J. Pharm. Pharmacol.

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Nephrolithiasis is a common, painful, costly and recurrent disease, the management of which remains to be an enigma. Phytotherapeutics could be useful as either alternative or complementary therapies in the management of nephrolithiasis. This study was designed to test the efficacy of Cymbopogon proximus (CP), a traditional Sudanese plant commonly known as "Mahareb", in preventing ethylene glycol-induced nephrolithiasis in rats. Thirty male Wistar albino rats were divided randomly into 3 groups of 10. Group 1 was the normal control. Group 2 (stone group) had free access to drinking water containing 0.75% ethylene glycol (EG) and 2% ammonium chloride (AC). Group 3 (test group) was treated as group 2 and was simultaneously injected with C. proximus 5% aqueous extract at a dose of 1.5 ml/100 g body weight/day for 10 days. At the end of the treatment period, serum levels of creatinine, blood urea nitrogen (BUN), calcium and phosphorous were determined; measurements of kidney calcium levels were also performed and kidney histopathological examinations were done. The stone group had the highest levels of serum calcium and BUN as well as the highest kidney calcium level. Large crystal deposits were also seen in this group. The CP treated group showed significantly lower levels of serum calcium, serum BUN and kidney calcium (p<0.01); crystal deposits were not observed in this group. The results obtained suggest that CP has a significant protective effect against ethylene glycol-induced nephrolithiasis in rats.

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Section: Discussionsupporting

confidence: 85%

Effect of Cymbopogon proximus (Mahareb) on ethylene glycol-induced nephrolithiasis in rats

Warrag¹,

Eldin²,

Ahmed³

2014

Afr. J. Pharm. Pharmacol.

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“…II, Table 1). In this study, we reported that response in 28 days ethylene glycol (0.75%) v/v administration in rats; forms renal calculi composed of mainly calcium oxalate (Bahuguna et al, 2009). The mechanism for this process may be due to an increase in the urinary concentration of oxalates.…”

Section: Discussionmentioning

confidence: 96%

Anti-urolithiatic effects of Punica granatum in male rats

Rathod

Biswas

Chitme

et al. 2012

Journal of Ethnopharmacology

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“…Also, its diuretic and tonic effects contribute to its wide use in painful micturition, calculus affections, and other urinary disorders (11,12). The therapeutic value of Urtica dioica and T terrestris extracts in lowering experimental hyperoxaluria has already been reported (13)(14)(15). Besides, reports indicate that, there is a degrading bacterium in the intestine of 70-80% of healthy people which solely extracts metabolic energy from oxalate (16,17).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous use of oxalate-degrading bacteria and herbal extract to reduce the urinary oxalate in a rat model: A new strategy

et al. 2019

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Objective: Urinary stones with oxalate composition can cause kidney failure. Recent fi ndings evidenced that probiotics are effective in reducing oxalate absorption in these subjects based on their high colonic absorption levels at baseline. The purpose of this study was to evaluate the effect of the simultaneous use of oxalate-degrading bacteria, Urtica dioica and T. terrestris extract in reducing urinary oxalate. Materials and Methods: Anti-urolithiatic activity of Urtica dioica and T. terrestris extract and probiotic by using ethylene glycol induced rat model. In this study, 4 strains of Lactobacillus and 2 strains of Bifi dobacterium and also 2 strains of L. paracasei (that showed high power in oxalate degrading in culture media) were used. Male Wistar rats were divided into four groups (n=6). The rats of group-I received normal diet (positive control group) and groups-II (negative control group), III, IV rats received diet containing ethylene glycol (3%) for 30 days. Groups III rats received Urtica dioica and T. terrestris extract. Groups IV rats received extracts + probiotic for 30 days. Findings: The results show that the use of herbal extracts (Urtica dioica and T. terrestris) reduced the level of urinary oxalate and other parameters of urine and serum. Also, the accumulation of calcium oxalate crystals in the kidney tissue was significantly reduced. Conclusion: Considering that the formation of calcium oxalate crystals can cause infl ammation and tissue damage in the kidney, the use of herbal extracts with oxalate degrading bacteria can be a new therapeutic approach to preventing the formation of kidney stones.

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Antilithiatic effect of flowers ofJasminum AuriculatumVahl

Cited by 28 publications

References 15 publications

Effect of Cymbopogon proximus (Mahareb) on ethylene glycol-induced nephrolithiasis in rats

Effect of Cymbopogon proximus (Mahareb) on ethylene glycol-induced nephrolithiasis in rats

Anti-urolithiatic effects of Punica granatum in male rats

Simultaneous use of oxalate-degrading bacteria and herbal extract to reduce the urinary oxalate in a rat model: A new strategy

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