Antileishmanial effect of silver nanoparticles: Green synthesis, characterization, in vivo and in vitro assessment

Awad, Manal A.; Olayan, Ebtesam M. Al; Siddiqui, Muzzammil Iqbal; Merghani, Nada M.; Alsaif, Sarah Saleh Abdu-llah; Aloufi, Abeer S.

doi:10.1016/j.biopha.2021.111294

Cited by 35 publications

(20 citation statements)

References 32 publications

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“…Noble metal nanoparticles, mainly silver nanoparticles (AgNPs) have been an attractive research subject due to their exceptional properties [ 1 ], such as biocompatibility, high surface area, quantum confinement, variable size, shape and structure (nanosphericals, nanorods, nanocubes and nanotriangles). AgNPs are extensively incorporated in various fields [ 2 ] such as in cosmetics [ 3 ], food packaging [ 4 ], bioengineering, biomedicine [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ] (biosensing, anticancer, antimicrobial, antileishmanial, antioxidant, medical treatment, drug delivery and cell imaging), catalysis [ 12 ], antimicrobial paints [ 13 ], surface cleaners, air and water disinfection [ 14 ] and wastewater treatment [ 15 ]. Various methods were successfully reported for the synthesis of silver nanoparticles including chemical and physical routes [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Polyvinylpyrrolidone Concentration on Properties and Anti-Bacterial Activity of Green Synthesized Silver Nanoparticles

et al. 2022

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Environmentally green synthesis of stable polyvinyl pyrrolidone (PVP)-capped silver nanoparticles (PVP-AgNPs) was successfully carried out. The present study focused on investigating the influence of adding PVP during the synthesis process on the size, optical properties and antibacterial effect of silver nanoparticles produced. An aqueous extract of Eucalyptus camaldulensis leaves was used as a reducing agent. The effects of different PVP concentrations and reducing time on the synthesis of nanoparticles (NPs) were characterized by UV–Vis spectrophotometry, scanning electron microscopy (SEM), energy dispersive spectrum (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and nano tracker analysis (NTA). The addition of PVP was studied. The prepared PVP-AgNPs were spherical with an average size of 13 nm. FTIR analysis confirmed that PVP protects AgNPs by a coordination bond between silver nanoparticles and both N and O of PVP. DLS results indicated the good dispersion of silver nanoparticles. PVP-AgNPs were found to be stable for nearly 5 months. Antibacterial studies through the agar well diffusion method confirmed that silver nanoparticles synthesized using PVP had no inhibitor activity toward Gram-positive and Gram-negative bacteria as opposed to silver nanoparticles prepared without adding PVP, which showed a significant antibacterial activity towards some of the tested pathogens.

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Section: Introductionmentioning

confidence: 99%

Influence of Polyvinylpyrrolidone Concentration on Properties and Anti-Bacterial Activity of Green Synthesized Silver Nanoparticles

et al. 2022

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“…Current research indicates that nitric oxide is not directly involved in the direct killing of leishmaniasis and may instead contribute to host tissue damage ( 70 ), however it has also been shown that downregulation of nitric oxide provides Leishmania with a form of immune escape via reduced host response ( 71 ), thereby suggesting that nitric acid is needed to prevent immune escape, thus implying that nitric acid is needed to initiate a host response against the parasite. Other studies have examined the use of silver nanoparticles exploiting their inherent antimicrobial / localised cytotoxicity either alone or in combination with UV light ( 72 , 73 ).…”

Section: Current Treatmentsmentioning

confidence: 99%

Current and future strategies against cutaneous parasites

2022

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Cutaneous parasites are identified by their specific cutaneous symptoms which are elicited based on the parasite’s interactions with the host. Standard anti-parasitic treatments primarily focus on the use of specific drugs to disrupt the regular function of the target parasite. In cases where secondary infections are induced by the parasite itself, antibiotics may also be used in tandem with the primary treatment to deal with the infection. Whilst drug-based treatments are highly effective, the development of resistance by bacteria and parasites, is increasingly prevalent in the modern day, thus requiring the development of non-drug based anti-parasitic strategies. Cutaneous parasites vary significantly in terms of the non-systemic methods that are required to deal with them. The main factors that need to be considered are the specifically elicited cutaneous symptoms and the relative cutaneous depth in which the parasites typically reside in. Due to the various differences in their migratory nature, certain cutaneous strategies are only viable for specific parasites, which then leads to the idea of developing an all-encompassing anti-parasitic strategy that works specifically against cutaneous parasites. The main benefit of this would be the overall time saved in regards to the period that is needed for accurate diagnosis of parasite, coupled with the prescription and application of the appropriate treatment based on the diagnosis. This review will assess the currently identified cutaneous parasites, detailing their life cycles which will allow for the identification of certain areas that could be exploited for the facilitation of cutaneous anti-parasitic treatment.

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“…11 Besides, leishmanicidal activity has also been reported for AgNPs. 12,13 AgNPs can be produced and stabilized, generally, by two approaches: top-down or bottom-up. The top-down strategy consists of synthesizing the nanostructure by physical wear of macroscopic materials, whether by grinding, spraying, laser ablation, or lithography, among others.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis, Characterization and Antibacterial and Leishmanicidal Activities of Silver Nanoparticles Obtained from Aqueous Extract of Eucalyptus grandis

Oliveira¹,

Silva²,

Braga³

et al. 2023

J. Braz. Chem. Soc.

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This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic band at 407 nm in the UV-Vis spectrum. The AgNPs presented a spherical shape and size of 9.7 ± 0.3 nm. The nanoparticles were stable over a month, indicating that E. grandis’ extract is suitable for their preparation and stabilization. The X-ray analysis showed that the crystallinity of AgNPs corresponded to the centered face phase of silver. The antibacterial and leishmanicidal activities of AgNPs were evaluated. The AgNPs presented antibacterial activity on the Gram-negative bacteria Escherichia coli at 53.9 µg mL–1. The leishmanicidal activity evaluation against promastigote forms of Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis showed that the biological response is dependent on the volume of AgNP suspension. It was demonstrated that L. infantum was more sensitive to the nanoparticle’s treatment than L. amazonensis and L. braziliensis. The treatment of L. infantum promastigotes with 150 µL of AgNP suspension reduced parasite growth by 67.9%, a result which was similar to the treatment with 1 (66.7%) or 2 µL (70.6%) of amphotericin B used as a positive control.

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Antileishmanial effect of silver nanoparticles: Green synthesis, characterization, in vivo and in vitro assessment

Cited by 35 publications

References 32 publications

Influence of Polyvinylpyrrolidone Concentration on Properties and Anti-Bacterial Activity of Green Synthesized Silver Nanoparticles

Influence of Polyvinylpyrrolidone Concentration on Properties and Anti-Bacterial Activity of Green Synthesized Silver Nanoparticles

Current and future strategies against cutaneous parasites

Green Synthesis, Characterization and Antibacterial and Leishmanicidal Activities of Silver Nanoparticles Obtained from Aqueous Extract of Eucalyptus grandis

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