Antileishmanial and trypanocidal activity of Brazilian Cerrado plants

Mesquita, Mariana Laundry de; Desrivot, Julie; Bories, Christian; Fournet, Alain; Paula, José Elías de; Grellier, Philippe; Espindola, Laïla Salmen

doi:10.1590/s0074-02762005000700019

Cited by 98 publications

(84 citation statements)

References 21 publications

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“…Seu óleo essencial foi citotóxico contra linhagens de células tumorais . C. sylvestris também mostrou significante atividade em Leishmania donovani e Trypanosoma cruzi (Mesquita et al, 2005). Contudo, apesar de ser bastante estudada, ainda há carência de estudos que possam comprovar o uso desta espécie no combate às hiperlipidemias e à obesidade.…”

Section: Em Nossa Senhora Do Livramento-mtunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:O presente trabalho verificou a utilização de plantas medicinais encontradas no Cerrado mato-grossense para o tratamento de hiperlipidemias e obesidade. Entrevistas com 180 pessoas acima de 50 anos foram realizadas em Nova Xavantina-MT. O questionário abordou nome popular, parte utilizada, forma de preparo e uso das espécies citadas, além de informações gerais sobre o uso de plantas. -Hil.). A folha foi a parte mais utilizada (46%) e o preparo das plantas ocorre principalmente por meio de infusão citado por 36,5% dos entrevistados. Apesar do uso popular destas plantas no combate as hiperlipidemias e obesidade, há necessidade de estudos fitoquímicos e farmacológicos que comprovem estas atividades, com vistas ao desenvolvimento de um fitoterápico.Unitermos: Levantamento etnobotânico, Nova Xavantina, plantas medicinais, anti-hiperlipidêmicas, anorexígenas, Cerrado.ABSTRACT: "Ethnobotanical survey of plants used as anti-hyperlipidemic and anorexigenic by the population of Nova Xavantina-MT, Brazil". This study checked the use of medicinal plants found in the Cerrado mato-grossense for the treatment of hyperlipidemia and obesity. Interviews with 180 people over 50 years were held in Nova Xavantina-MT. The questionnaire addressed popular name, part used, type of preparation and use of the species mentioned, beyond general information about the use of plants. The ten plants most cited were collected, identified and studied through a literature review. Most respondents (95.6%) said using medicinal plants regularly, while 71.5% of them inherited the knowledge of plants of parents and grandparents and 94.20% reported the use to advise youngsters. Furthermore, 93.6% attested that the plants are more effective than the drugs from pharmacy and 57% considered the strong effect of the same, i.e., they always solved health problems. Regarding adverse effects, 95.9% said they have never felt them after the use of plants. Of the respondents, 56.7% knew or had used medicinal plants in the treatment of hyperlipidemias and obesity, being cited 54 medicinal species belonging to 53 different genera and 38 families, with emphasis on Fabaceae (13%

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Section: Em Nossa Senhora Do Livramento-mtunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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“…Os alcaloides indólicos dos representantes do gênero apresentam diversas atividades farmacológicas, entre elas antimicrobiana (Silva et al, 1998;Neto et al, 2002;Morel et al, 2006), antitumoral (Wood et al, 2001), antiprotozoária (Deharo et al, 2001;Mesquita et al, 2005;Castillo et al, 2007) e anti-inflamatória (Miranda et al, 2000). Himatanthus lancifolius (Müll.…”

Section: Introductionunclassified

Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: estudo farmacobotânico de uma planta medicinal da Farmacopeia brasileira 1ª edição

Baratto¹,

Hohlemwerger²,

Guédès³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Himatanthus lancifolius (Müll. Arg.) Woodson é um arbusto nativo do Brasil, latescente, popularmente conhecido como agoniada e utilizado principalmente para distúrbios menstruais. O presente trabalho teve como objetivo caracterizar morfoanatomicamente a folha, o caule e a casca caulinar dessa planta medicinal, a fim de contribuir para o controle de qualidade e a autenticidade dessa espécie. O material vegetal foi fixado e submetido às microtécnicas usuais. A folha é simples, glabra e obovado-lanceolada. A epiderme é uniestratificada, revestida por cutícula estriada e possui estômatos anisocíticos na face abaxial. O mesofilo é dorsiventral. A nervura central é biconvexa e o pecíolo é circular, ambos apresentando feixes vasculares bicolaterais. Laticíferos, amiloplastos e idioblastos fenólicos estão presentes no parênquima fundamental da nervura central e do pecíolo. O sistema vascular do caule é tipicamente bicolateral. Laticíferos e idioblastos fenólicos ocorrem no córtex, no floema e na medula. Esses caracteres morfoanatômicos, em conjunto, podem ser utilizados como parâmetros para o controle de qualidade dessa espécie.Unitermos: Apocynaceae, floema interno, Himatanthus lancifolius, laticíferos, morfoanatomia.ABSTRACT: "Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: morphoanatomical study of a medicinal plant described in the Brazilian Pharmacopoeia 1st edition". Himatanthus lancifolius (Müll. Arg.) Woodson is a Brazilian native shrub, laticiferous, popularly known as "agoniada". It is mainly used for uterine disorders. The present work aimed to study the leaf, stem and stem bark morpho-anatomy of this medicinal plant, in order to contribute to its quality control and identification. The plant material was fixed and submitted to standard microtechniques. The leaf is simple, glabrous and obovate-lanceolate. The epidermis is uniseriate, coated with striated cuticle and it has anysocitic stomata on the abaxial surface. The mesophyll is dorsiventral. The midrib is biconvex and the petiole is circular, both present bicollateral vascular bundles. Laticiferous ducts, amyloplasts and phenolic idioblasts are found in ground parenchyma of the midrib and petiole. The vascular system of the stem is tipically bicollateral. Laticiferous ducts and phenolic idioblasts are present in the cortex, phloem and pith. These morpho-anatomical characters, all together, can be used as quality control parameters of this species.

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“…It is interesting to point out that the extract was more specific for intracellular form of L. braziliensis (specificity index= 3.8) and this result reinforces the potential leishmanicidal activity of C. sylvestris. Previously, Mesquita et al (2005) demonstrated the antileishmanial potential of C. sylvestris against promastigotes forms of L. donovani, of which extracts displayed a significant activity with IC 50 values ranging from 0.1 to 4.9 µg/mL depending on the plant parts used.…”

Section: Resultsmentioning

confidence: 99%

“…2011). Pharmacological studies have highlighted the promising bioactive potential of extracts and compounds isolated from C. sylvestris, especially its antitumor (Ferreira et al 2010), anti-ulcer (Da Silva et al 2008), antifungal (Alves et al 2000, antibacterial (Chiappeta et al 1983), antioxidant (Menezes et al 2004 and (Mesquita et al 2005). Phytochemical studies have attributed the high antitumor activity of C. sylvestris to the numerous secondary metabolites, especially diterpenes, which are likely based on its larger hydrophobicity and facility to penetrate across cell membrane and interact with intracellular targets (Ferreira et al 2010).…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris

Antinarelli

Pinto

Scio

et al. 2015

An. Acad. Bras. Ciênc.

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Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC 50 values below of 20 µg/mL against at least one species of Leishmania. Casearia sylvestris showed the most expressive activity against all promastigote forms of Leishmania species (IC 50 values of 5.4 µg/mL, 5.0 µg/mL, 8.5 µg/mL and 7.7 µg/ mL for L. amazonensis, L. braziliensis, L. chagasi and L. major, respectively), being more effective than the reference drug miltefosine. In spite of the cytotoxic effect on macrophages (CC 50 value of 5.2 µg/mL), C. sylvestris exhibited a strong inhibition against intracellular amastigotes of L. braziliensis (IC 50 value of 1.3 µg/ mL). Further studies, including bio-guided fractionation will be conducted to identify the active compounds.

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Antileishmanial and trypanocidal activity of Brazilian Cerrado plants

Cited by 98 publications

References 21 publications

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: estudo farmacobotânico de uma planta medicinal da Farmacopeia brasileira 1ª edição

Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris

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