Antiinflammatory activity of extracts from Aloe vera gel

Vázquez, Beatriz Y. Salazar; Ávila, Guillermo; Segura, David San Martín; Escalante, Bruno

doi:10.1016/s0378-8741(96)01476-6

Cited by 303 publications

(192 citation statements)

References 10 publications

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“…The statistical difference observed at seven days for the variables, inflammation (p=0.045) and at seven and 30 days for bone formation (p=0.018 and p=0.034, respectively) ( Table 2 and Figure 1) showed that in spite of the initial tissue necrosis, the anti-inflammatory repairing capacity of Aloe vera was superior, corroborating findings by Vázquez et al 17 , Duansak et al 18 and Prabjone et al 20 , when they emphasized the analgesic and steroidal capacity of Aloe vera in their studies.…”

Section: Discussionsupporting

confidence: 88%

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Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Fé

Coelho

Damascena

et al. 2014

Rev. odontol. UNESP

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AIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bone defects with approximately 5 mm in diameter were made on the right tibia of each animal: the upper defect was filled with blood coagulates in both groups to serve as experimental control and the lower defect was filled with MTA and Aloe vera in experimental (group E1) and MTA and distilled water in experimental (group E2). Seven, 15 and 30 days after surgery, six animals from each group were euthanized and the right tibia of each animal was removed for histological analysis.RESULT: Histologically, experimental group E1 presented better results for the two variables, inflammation [at seven days (p=0.045)] and bone formation [at seven days (p=0.018) and 30 days (p=0.034)], compared to the E2 group.CONCLUSION: The association of MTA and Aloe vera showed potential to reduce the effects of the inflammatory cascade and promote bone neoformation making it to a promising proposal for future use in endodontic therapy.

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Section: Discussionsupporting

confidence: 88%

“…This decrease of inflammation observed may also be explained by the anti-inflammatory property of Aloe vera, through the immunomodulatory effect of the polysaccharides acetylated mannose (mannose-6-phosphate), acemannan and veraciglucans A, B and C, according to the findings of other studies [16][17][18][19][20] .…”

Section: Discussionmentioning

confidence: 54%

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Fé

Coelho

Damascena

et al. 2014

Rev. odontol. UNESP

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“…vera leaf extract (AvLE) is a very excellent source of plant nutrients, such as calcium, iron, magnesium, potassium, phosphorous and zinc (Dagne et al 2000); enzymes, such as amylase, catalase, lipase, oxidase and superoxide dismutase (Vazquez et al 1996); amino acids, such as alanine, glycine, leucine and proline (Reynolds and Dweck 1999); vitamins. such as B-complex, C,β-carotene and α-tocopherol (Vinson et al 2005); and other organic compounds, such as triglicerides, triterpenoid, gibberellin, potassium sorbate and salicylic acid (Hamman 2008).…”

mentioning

confidence: 99%

The Effects of <i>Aloe vera</i> L. Leaf Extract on Some Physiological and Cytogenetical Parameters in <i>Allium cepa</i> L. Seeds Germinated under Salt Stress

2016

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SummaryThe present study was performed to evaluate the role of Aloe vera L. leaf extract (AvLE) on some physiological and cytogenetical parameters of Allium cepa L. seeds exposed to salinity. The radicle length of the seeds germinated in the medium with AvLE alone increased as compared with ones of the control seeds germinated in distilled water medium, while their radicle number and fresh weight reduced according to the control. In addition, the germination percentage of the mentioned seeds statistically was the same as the control seeds. Furthermore, the seeds germinated in the media containing 0.1 mg/L AvLE alone showed a significant increase of mitotic index, although they exhibited a higher number of chromosomal aberrations and micronucleus (MN) formation as compared with the seeds germinated in control conditions. On the other hand, salt stress considerably inhibited the seed germination and seedling growth of A. cepa. Moreover, salinity markedly decreased the mitotic index in root tip meristems of the seeds and increased the number of chromosomal aberrations. The negative effect of salt on the seed germination, seedling growth, mitotic activity and MN formation was alleviated in dramatically varying degrees by AvLE application. In contrast, the detrimental effects of salt on the chromosomal aberrations greatly increased with this treatment. Consequently, we reported that the application of AvLE alone induced chromosomal aberrations and MN formation, which are an indicator of genotoxicity, and had cytotoxic activity in normal conditions. However, the frequency of MN is greatly reduced in root tip cells of the seeds germinated in the medium containing 0.1 mg/L AvLE +0.15 M NaCl.

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“…The oral administration of aloe stimulates the humoral immune system and slows down the action by the cellular pathway avoiding injury caused by exacerbated cellular response [17]. In addition, it promotes areduced colony-forming units in the peritoneal cavity in CLP-induced septic animals, acting as an antiseptic agent [9].…”

Section: Discussionmentioning

confidence: 99%

Aloe vera delays mortality, but does not attenuate kidney injury in septic mices

et al. 2016

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Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture. Methods and Findings:Twenty six mice were distributed into four groups: Sham -surgery simulation (N=5); Control -Cecal ligation and puncture was performed (N=7); Aloe -Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe -Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p<0.01). There were no difference between the Sham and Aloe groups and between Control and Sepsis + Aloe groups according to the four parameters analyzed (p>0.05). Conclusions:Aloe vera delays mortality but does not attenuate kidney injury.

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Antiinflammatory activity of extracts from Aloe vera gel

Cited by 303 publications

References 10 publications

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

The Effects of <i>Aloe vera</i> L. Leaf Extract on Some Physiological and Cytogenetical Parameters in <i>Allium cepa</i> L. Seeds Germinated under Salt Stress

Aloe vera delays mortality, but does not attenuate kidney injury in septic mices

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