Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis

Abstract

Geniposide (GE), an iridoid glycoside compound purified from Gardenia jasminoides Ellis, has antiinflammatory and other pharmacological effects, but its mechanism of actions on rheumatoid arthritis (RA) have not been clarified. The purpose of this article was to investigate the pharmacological effects of GE on collagen-induced arthritis (CIA) rats and its feasible mechanisms. Collagen-induced arthritis was induced by injection of chicken type II collagen emulsion. The rats were orally administered with GE (33, 66, and 132 mg/kg) from days 14 to 30 after immunization. The histological examination showed that GE could attenuate histopathologic changes of mesenteric lymph node (MLN) in CIA rats. Geniposide inhibited the production of Interleukin 6 (IL-6) and IL-17, while promoting the production of IL-4 and transforming growth factor-beta 1 in MLN lymphocytes (MLNLs). Moreover, the proliferation capability of MLNLs was increased after the administration of GE. In addition, the treatment with GE in vivo decreased the expressions of P-Raf, P-MEK, and P-Erk1/2 in MLNLs. These results may highlight the antiinflammatory effects and possible mechanisms of GE in MLNLs of RA. Copyright © 2017 John Wiley & Sons, Ltd.

A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product

“…; 33, 66, 132 mg/kg) was observed to improve the cell proliferation of mesenteric lymph node lymphocytes (MLNLs); to decrease IL-6 and IL-17; to increase IL-4 and TGF-β1; and to attenuate histopathological changes. The rapidly accelerated fibrosarcoma/mitogen activated protein kinase kinase/extracellular signal-regulated kinase1/2(Raf/MEK/ERK 1/2) signaling pathway in MLNLs is considered to be involved in the mechanism of this bioactivity [ 171 ]. Allergic asthma, which is related to immune responses, is considered as a chronic inflammatory disease to the respiratory system with the cardinal pathophysiological symptoms, such as airway hyperresponsiveness, bronchoalveolar lavage eosinophilia, mucus hypersecretion;as well as increased levels of T-helper-2-associated cytokines, chemokines and serum ovalbumin (OVA)-specific immunoglobulin E (IgE).…”

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

“…Triptolide inhibits the inflammatory response of monocytes by regulating miR‐155 (Peng et al, ). Geniposide, baicalin, and norisoboldine reduce lymphocyte proliferation and expansion and suppress the inflammatory responses induced by lymphocyte (Dai et al, ; Luo et al, ; Wang et al, ; Yang, Yang, & Zou, ). Monocytes can differentiate into macrophages, which play a pivotal role in the induction and progression of inflammatory processes (Liu et al, ).…”

“…Curcumin can decrease thymic weight in RA model rats (Cai et al, ). Triptolide, geniposide, astragaloside IV, hesperidin, and curcumin modulate the proliferation and activation of lymphocytes (Li et al, ; Li, Li, et al, ; Liu, Lin, Jia, Xiao, & Zhang, ; Wang & Chen, ; Wang, Wu, et al, ; Yang et al, ).…”

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

“…Geniposide exerted antiinflammatory activity by suppressing hind paw swelling and reducing clinical scores of collagen‐induced arthritis (CIA) rats (Li et al ., ). In addition, GE can significantly decrease the production of interleukin (IL)‐4, IL‐17, and TGF‐beta1 (TGF‐β1) in peripheral blood lymphocytes and mesenteric lymph node (MLN) lymphocytes of arthritis rats (Dai et al ., ; Wang et al ., ). These effects were related to the amelioration of Jun N ‐terminal kinase mitogen‐activated protein kinases (MAPKs) signaling and p38MAPKs signaling cascade in peripheral blood lymphocytes, fibroblast‐like synoviocytes, and MLN lymphocytes (Chen et al ., ).…”