Antihypertensive Therapy Versus Alternative Therapeutic Options for Prehypertension: an evidence-based Approach

Gaddam, Krishna K.; Ventura, Héctor O.; Lavie, Carl J.

doi:10.2217/fca.11.83

Cited by 5 publications

(2 citation statements)

References 48 publications

(38 reference statements)

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“…3 In previous studies, pharmacological intervention reduced BP in prehypertensive subjects but the effect was associated with adverse side-effects of drugs. [23][24][25][26] Thus, a nonpharmacological intervention without any ill effects could be a good alternative. In our study, we observed a significant reduction in both systolic and diastolic BP in both the groups after 12 weeks of intervention.…”

Section: Discussionmentioning

confidence: 99%

Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study

Thiyagarajan

Pal

et al. 2014

Hypertens Res

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High blood pressure (BP) is a known risk factor for cardiovascular disease morbidity. Considering the growing evidence of nonpharmacological interventions in the management of high BP, we designed a randomized, parallel active-controlled study on the effect of yoga and standard lifestyle modification (LSM) on BP and heart rate in individuals with prehypertension (systolic BP 120-139 mm Hg and/or diastolic BP 80-89 mm Hg). Volunteers (20-60 years) of both genders without any known cardiovascular disease were randomized into either LSM group (n = 92) or LSM+yoga group (n = 92). Before the intervention, age, waist circumference, physical activity, BP and fasting plasma glucose and lipids were comparable between the groups. After 12 weeks of intervention, we observed a significant reduction in the BP and heart rate in both the groups. Further, the reduction in systolic BP was significantly more in LSM+yoga group (6 mm Hg) as compared with LSM group (4 mm Hg). In addition, 13 prehypertensives became normotensives in LSM+yoga group and four in LSM group. The results indicate efficacy of nonpharmacological intervention and the additional benefit of yoga to standard LSM. Further research in this field may add to the level of evidence on the benefit of yoga, in the reduction of BP in high BP subjects, in the scientific literature.

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Section: Discussionmentioning

confidence: 99%

Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study

Thiyagarajan

Pal

et al. 2014

Hypertens Res

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“…Moreover, 169 individuals with prehypertension need to be treated with an antihypertensive drug for 4.3 years to prevent one stroke, indicating a relatively high number needed to treat in prehypertension [79]. Collectively, the pharmacological therapy of prehypertension remains a topic of lively discussion and debate [80][81][82][83].…”

Section: Attenuation or Delay Of Progressionmentioning

confidence: 99%

Prehypertension, the Risk of Hypertension and Events

Doumas

Katsiki

Mikhailidis

2018

Updates in Hypertension and Cardiovascular Protection

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Highlights• Prehypertension is a precursor of hypertension in a high proportion of individuals. • Several factors may predispose to the development of prehypertension including uric acid, dietary salt intake, arterial stiffness, autonomic imbalance, obesity, and subclinical inflammation. • Progression of prehypertension to hypertension has been associated with visceral abdominal fat, sympathetic overactivity, sympathovagal imbalance, endothelial dysfunction, impairment of coronary flow reserve, and metabolic syndrome. Age, gender, ethnicity, and baseline blood pressure may also affect the incidence of hypertension. • Prehypertension is associated with increased risk for coronary heart disease, stroke, chronic kidney disease, and cardiovascular death, but not all-cause mortality. • Lifestyle measures and antihypertensive drugs may delay or even prevent the progression of prehypertension to hypertension.

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Essential hypertension treated by wuling powder and modified tianma gouteng decoction: A cohort study without controls

Zheng

2013

Complementary Therapies in Medicine

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Antihypertensive Therapy Versus Alternative Therapeutic Options for Prehypertension: an evidence-based Approach

Cited by 5 publications

References 48 publications

Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study

Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study

Prehypertension, the Risk of Hypertension and Events

Essential hypertension treated by wuling powder and modified tianma gouteng decoction: A cohort study without controls

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