Functional dyspepsia is a common functional gastrointestinal disorder according to Rome IV and received less attention over past years. Association between gut and brain has been revealed recently, which leads to novel treatments of functional gastrointestinal disorder including different psychosomatic therapy ways. Here, we present a classical functional dyspepsia patient with anxiety and depression. We treated the patient with drugs combined psychosomatic therapy, such as Wuling capsule, cognitive behavioral therapy, and happiness therapy. Both syndromes of dyspepsia and anxiety-depression has been improved after 6 weeks' treatments. This case reveals importance of psychosomatic therapy in functional gastrointestinal disorder and suggests individualized treatment is potentially effective strategy for psychosomatic disorder.