Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy

Ma, Weizhong; Lü, Xing; Su, Zuowei

doi:10.1080/21655979.2021.2014620

Cited by 2 publications

(1 citation statement)

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“…The treatment group (Group C/D/E) was given the corresponding solution of high and low doses of STE or benazepril orally via gavage 2 days before the experiment. On the third day, two hours after the completion of the corresponding solution, Group A was given normal saline in the tail vein, while the other groups (Group B/C/D/E) were injected with Adriamycin (prepared at a concentration of 1 mg/ml with 0.9% normal saline) in the tail vein at a dose of 7.5 mg/kg, as reported in previous studies (Bertani et al 1982;Squadrito et al 1992;Wang et al 2015;Ma et al 2022). After the injection of Adriamycin, STE or benazepril was intragastrically administered to Group C/D/E at a dose of 10 ml/kg, for 3 consecutive weeks.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

Renoprotective effects of Schoenoplectus tabernaemontani rhizomes aqueous extracts against Adriamycin-induced nephropathy in rats

Peng,

Huang,

Gao

et al. 2024

Natural Product Research

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In recent years, chronic kidney disease (CKD) has emerged as an increasingly significant issue due to the growing prevalence and high treatment costs. While recorded the positive diuretic effect of Schoenoplectus tabernaemontani, there is a lack of reports on its efficacy in treating CKD. The pharmacological effects and mechanisms of Schoenoplectus tabernaemontani rhizomes aqueous extracts (STE) in CKD were investigated by inducing a rodent model of CKD via injection of Adriamycin (7.5 mg/kg) into the tail vein of Wistar rats. In summary, our findings suggest that STE has a beneficial effect on anti-renal fibrosis and can reverse Adriamycin-induced renal injury by suppressing oxidative stress and inflammation.Therefore, STE holds promising potential as a treatment option for CKD. each vial. STE was stored a −20 °C and taken out one day in advance. Animals and experimental designWe obtained specific pathogen-free (SPF) male Wistar rats (180-220 g) from Hunan SJA Laboratory Animal Co., Ltd. They were housed in the animal house of the

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Section: Chemicals and Reagentsmentioning

confidence: 99%