Antihypertensive nano-ceuticales based on chitosan biopolymer: Physico-chemical evaluation and release kinetics

Niaz, Taskeen; Shabbir, Saima; Manzoor, Shahid; Rehman, Asma; Rahman, Abdur; Nasir, Habib; Imran, Muhammad

doi:10.1016/j.carbpol.2016.01.047

Cited by 48 publications

(22 citation statements)

References 22 publications

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“…Previous studies have revealed that decoration of liposomal surface with biomacromolecules is an effective way to reduce the damage of lipid membrane and associated leakage of encapsulated compounds (Caddeo et al, 2016 ; Tan et al, 2016 ; Adamczak et al, 2017 ; Peng et al, 2017 ). Chitosan (CTS) is a carbohydrate based poly-cationic linear polymer consisting of (1–4) linkages between D-glucosamine and N-acetyl-D-glucosamine units, and it has demonstrated high biodegradability and biocompatibility (Niaz et al, 2016 ). Due to the presence of amino groups, chitosan acts as a cationic polymer and makes electrolytic complexes with the oppositely charged molecules (Paques et al, 2014 ; Li et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

et al. 2018

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Food grade micro- or nano-carrier systems (NCS) are being developed to improve the controlled release of antimicrobial agents. To augment the stability of liposomal NCS and to overcome the limitations associated with the use of free bacteriocin (nisin) in the food system, multi-component colloidosomes (MCCS) were developed by electrostatic interactions between anionic alginate and cationic chitosan (multilayer) around phospholipids based liposomes (core). Zeta-sizer results revealed the average diameter of 145 ± 2 nm, 596 ± 3 nm, and 643 ± 5 nm for nano-liposome (NL), chitosomes (chitosan coated NL) and MCCS, respectively. Zeta potential values of NCS varied from −4.37 ± 0.16 mV to 33.3 ± 6 mV, thus both chitosomes (CS) and MCCS were positively charged. Microstructure analysis by scanning electron microscope (SEM) revealed relatively higher size of MCCS with smooth and round morphology. TGA and DSC based experiments revealed that MCCS were thermally more stable than uncoated liposomes. Encapsulation efficiency of nisin in MCCS was observed to be 82.9 ± 4.1%, which was significantly higher than NL (56.5 ± 2.5%). FTIR analyses confirmed the cross-linking between sodium alginate and chitosan layer. Both qualitative (growth kinetics) and quantitative (colony forming unit) antimicrobial assays revealed that nisin loaded MCCS have superior potential to control resistant foodborne pathogens including Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis, (5.8, 5.4, and 6.1 Log CFUmL−1 reduction, respectively) as compared to free nisin, loaded NL or CS. Controlled release kinetics data fitted with Korsmeyer–Peppas model suggested that nisin release from MCCS followed Fickian diffusion. Cytotoxic studies on human blood cells and HepG2 cell lines revealed hemocompatibility and non-toxicity of MCCS. Thus, due to enhanced controlled release, stability and biocompatibility; these multi-component colloidosomes can be useful for incorporating antimicrobial agents into functional foods, beverages and pharmaceutical products to combat pathogenic and spoilage bacteria.

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Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

et al. 2018

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“…The chain structure of chitosan is mainly composed of β-(1,4) linked D-glucosamine [8]. As the only alkaline polysaccharose in the nature, chitosan has several extraordinary advantages, including biocompatibility, biodegradability, and innoxious [9][10][11][12], which brings some level of applications involving food [13], pharmaceutical [14,15], beverages [16], papermaking [17,18], packaging [19,20], and textiles [21]. However, chitosan has the poor water solubility in neutral and alkaline condition [22], due to the linear aggregation of chain molecules and the formation of crystallinity caused by its intra and intermolecular hydrogen bonds [23], limits its further industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and antifungal property of chitosan ammonium salts with halogens

Tan

Dong

et al. 2016

International Journal of Biological Macromolecules

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In this study, a group of novel water soluble chitosan ammonium salts with halogens were successfully synthesized, including chitosan-bromoacetate (CSB), chitosan-chloroacetate (CSC), chitosan-dichloroacetate (CSDC), chitosan-trichloroacetate (CSTC), and chitosan-trifluoroacetate (CSTF), and their antifungal activities against three kinds of phytopathogens were comparatively estimated by hypha measurement in vitro, respectively. The fungicidal assessment revealed that the synthesized chitosan derivatives had higher antifungal activity than chitosan. Especially, the inhibitory indices of CSTC and CSTF against three kinds of phytopathogens were higher than 70% at 1.0mg/mL. Generally, the antifungal activity decreased in the order: CSTF>CSTC>CSDC>CSC>CSB>chitosan. Apparently, the order of antifungal activity was consistent with the electronegativity of different substituted groups with halogens. The substituted groups with stronger electronegativity could augment the positive charge densities of cationic amino groups by drawing more electrons from the cationic amino groups of chitosan ammonium salts, which demonstrated that the protonation of amino groups was significant for the antifungal activity of chitosan derivatives.

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“…51 Shah et al, 52 indicated that felodipine-loaded poly-(lactic-co-glycolic) acid (PLGA) NPs can control blood pressure and change ECG for extended duration by bypassing the prophase metabolism and providing sustained drug release. 52 Moreover, Niaz et al 53 elaborated the new polymer nanowire is a new type of antihypertensive drug (angiotensin-converting enzyme inhibitor, beta blockers, and CCB) with stable, high cation and even dispersion. It has good encapsulation efficiency.…”

Section: Application Of Nps In Hypertensionmentioning

confidence: 99%

“…The hydrophilicity of chitosan as a biological carrier helps to improve the oral bioavailability of antihypertension drugs. 53 Dudhipala et al 54 devised a nisoldipine SLN whose peak serum concentration (C max ) and AUC total are significantly higher than oral drug suspension (12.55±0.6 mg/mL vs 7.53±0.13 mg/mL, 96.15±3.92 mg/mL/h vs 44.13±2.90 mg/mL/h, respectively). Additionally, the removal rate of nisoldipine in SLN formulation is relatively slow, which makes biological half-life (t 1/2 ) and mean residence time of SLN formulation higher.…”

Section: Application Of Nps In Hypertensionmentioning

confidence: 99%

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases

Li¹,

Liang²,

Xiao³

et al. 2018

IJN

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Cardiovascular diseases (CVDs) are one of the most important causes of mortality and affecting the health status of patients. At the same time, CVDs cause a huge health and economic burden to the whole world. Although a variety of therapeutic drugs and measures have been produced to delay the progress of the disease and improve the quality of life of patients, most of the traditional therapeutic strategies can only cure the symptoms and cannot repair or regenerate the damaged ischemic myocardium. In addition, they may bring some unpleasant side effects. Therefore, it is vital to find and explore new technologies and drugs to solve the shortcomings of conventional treatments. Nanotechnology is a new way of using and manipulating the matter at the molecular scale, whose functional organization is measured in nanometers. Because nanoscale phenomena play an important role in cell signal transduction, enzyme action and cell cycle, nanotechnology is closely related to medical research. The application of nanotechnology in the field of medicine provides an alternative and novel direction for the treatment of CVDs, and shows excellent performance in the field of targeted drug therapy and the development of biomaterials. This review will briefly introduce the latest applications of nanotechnology in the diagnosis and treatment of common CVDs.

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Antihypertensive nano-ceuticales based on chitosan biopolymer: Physico-chemical evaluation and release kinetics

Cited by 48 publications

References 22 publications

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

Polyelectrolyte Multicomponent Colloidosomes Loaded with Nisin Z for Enhanced Antimicrobial Activity against Foodborne Resistant Pathogens

Synthesis, characterization, and antifungal property of chitosan ammonium salts with halogens

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases

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