Antihypertensive effect of total flavone extracts from Puerariae Radix

Cai, Rong; Li, Meng; Xie, Shengsong; Yang, Song; Zou, Zhong‐Mei; Zhu, Chunyan; Qi, Yun

doi:10.1016/j.jep.2010.09.013

Cited by 37 publications

(18 citation statements)

References 19 publications

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“…However, for the 1 st time we reported its action of GLP-1, GIP, TNF-alpha, IL-6 and HIF-1 in different experimental conditions of diabetes and kidney damage (Shukla et al, 2017) . These results are according to earlier reports related to the role of different pure phytochemicals, which are also found in PT tubers (Bebrevska et al, 2008) (Cai et al, 2011) .The pre-clinical toxicity with reference to the effect of test drugs on different organs is one of the mandatory criteria for commercial release of any drug. Now, after WTO agreement, the OECD guidelines are mandatory.…”

supporting

confidence: 87%

Histopathological Study Of Different Organs Of Charles Foster Rats Under The Exposure Of Pueraria tuberosa

Pandey

Srivastava

Singh

et al. 2019

Preprint

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Objective: The present study was undertaken to investigate the safe doses of Pueraria tuberosa water extract (PTWE) on different organs .Methodology: Haematoxylin and eosin staining was used to study the morphological alterations in heart, intestine, testis, adrenal gland and spleen. Followed the OECD guidelines 407 of repeated toxicity with respect to the selection of dose and days for different organs. The selected doses of PTWE were 250, 500, 1000 and 2000 mg/kg bw and the durations selected were 7, 14, 21 and 28 days. Result:According to the obtained results, we have found no any types of adverse alteration in cardiac fibers of the heart, size and shapes in crypts and villi of intestine, semeniferous tubules and spermatozoa count were normal in testis, all three zones of adrenal gland were normally identified and no any adverse sign of pulps in spleen was seen in all treated groups of PTWE Conclusion:There was no any types of adverse morphological alteration found in any organs. The drug PTWE are safe at 1000 mg/kg bw upto 28 days and 2000 mg/ kg bw upto 21 days respectively.

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supporting

confidence: 87%

Histopathological Study Of Different Organs Of Charles Foster Rats Under The Exposure Of Pueraria tuberosa

Pandey

Srivastava

Singh

et al. 2019

Preprint

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“…[78] Puerarin and daidzein are the major bioactive isoflavonoids isolated from the roots of Radix Puerariae . [9] Puerarin is used as a phytochemical marker for the quality control of Radix Puerariae in the Chinese pharmacopoeia and daidzein is also a major isoflavonoid.…”

Section: Introductionmentioning

confidence: 99%

LC-MS/MS determination and pharmacokinetics study of puerarin and daidzein in rat plasma after oral administration of Gegenqinlian decoction and Radix Puerariae extract

Zhang¹,

Yuan²,

Wang³

et al. 2014

Phcog Mag

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Background:Gegenqinlian decoction (GQD) is a famous traditional medicine recipe. It is composed of four herbs including Radix Puerariae (GG), Radix Scutellariae (HQ), Rhizoma Coptidis (HL) and Radix Glycyrrhizae (GC), which is widely used for treating gastro-intestinal disorders in the clinical practice of Traditional Chinese medicine (TCM). The aim of this study was to compare the pharmacokinetics of puerarin and daidzein in rats following oral administration of Gegenqinlian Decoction and Radix Puerariae extract. Thus, a sensitive and selective liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of puerarin and daidzein in rat plasma following oral administration of Gegenqinlian Decoction and Radix Puerariae extract.Materials and Methods:Chromatographic separation was performed on a Shiseido CAPCELL PAK C18 analytical column (100 mm × 2.0 mm i.d., 5 μm) by linear gradient elution, with water (0.1% formic acid)-acetonitrile (0.1% formic acid) as mobile phase. Detection was carried out by multiple reaction monitoring (MRM) mode using electrospray ionization in the positive ion mode.Results:The calibration curves were linear over a range of 7.80-1560 ng/mL for puerarin and 6.30-1260 ng/mL for daidzein. The intra- and inter-day precision values were less than 13.6% and their average recoveries was in the range of 77.8% and 88.6% for puerarin and was between 76.3 and 86.8% for daidzein, respectively.Conclusion:The validated method was applied to the comparative pharmacokinetic studies of puerarin and daidzein after oral administration of Gegenqinlian Decoction and Radix Puerariae extract. The pharmacokinetic parameters showed that puerarin and daidzein from Gegenqinlian Decoction were absorbed more effectively with slower elimination in rat plasma than that from Radix Puerariae extract. These results revealed that as far as the Radix Puerariae extract was concerned, it is very valuable to be used as a clinical directions of Gegenqinlian Decoction.

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“…Wistar-Kyoto treated with enalapril and the extracts of C. papaya roots diminished increases in MAP in a renovascular model of hypertension [2]. Polyphenolic and flavonoid substances were identified in a methanolic extract of C. papaya that showed ACE inhibitory activity [6][7][8] and antihypertensive effects [9][10][11]. ACE is a component of the RAS, which is responsible for the longterm control of blood pressure [12,13].…”

Section: Acementioning

confidence: 99%

Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex

et al. 2014

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The aims of this study were to evaluate the antihypertensive effects of the standardised methanolic extract of Carica papaya, its angiotensin converting enzyme inhibitory effects in vivo, its effect on the baroreflex and serum angiotensin converting enzyme activity, and its chemical composition. The chemical composition of the methanolic extract of C. papaya was evaluated by liquid chromatography-mass/mass and mass/mass spectrometry. The angiotensin converting enzyme inhibitory effect was evaluated in vivo by Ang I administration. The antihypertensive assay was performed in spontaneously hypertensive rats and Wistar rats that were treated with enalapril (10 mg/kg), the methanolic extract of C. papaya (100 mg/kg; twice a day), or vehicle for 30 days. The baroreflex was evaluated through the use of sodium nitroprusside and phenylephrine. Angiotensin converting enzyme activity was measured by ELISA, and cardiac hypertrophy was evaluated by morphometric analysis. The methanolic extract of C. papaya was standardised in ferulic acid (203.41 ± 0.02 µg/g), caffeic acid (172.60 ± 0.02 µg/g), gallic acid (145.70 ± 0.02 µg/g), and quercetin (47.11 ± 0.03 µg/g). The flavonoids quercetin, rutin, nicotiflorin, clitorin, and manghaslin were identified in a fraction of the extract. The methanolic extract of C. papaya elicited angiotensin converting enzyme inhibitory activity. The antihypertensive effects elicited by the methanolic extract of C. papaya were similar to those of enalapril, and the baroreflex sensitivity was normalised in treated spontaneously hypertensive rats. Plasma angiotensin converting enzyme activity and cardiac hypertrophy were also reduced to levels comparable to the enalapril-treated group. These results may be associated with the chemical composition of the methanolic extract of C. papaya, and are the first step into the development of a new phytotherapic product which could be used in the treatment of hypertension.

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Antihypertensive effect of total flavone extracts from Puerariae Radix

Cited by 37 publications

References 19 publications

Histopathological Study Of Different Organs Of Charles Foster Rats Under The Exposure Of Pueraria tuberosa

Histopathological Study Of Different Organs Of Charles Foster Rats Under The Exposure Of Pueraria tuberosa

LC-MS/MS determination and pharmacokinetics study of puerarin and daidzein in rat plasma after oral administration of Gegenqinlian decoction and Radix Puerariae extract

Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex

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