Antihyperlipidemic Potential of Fruits of Tribulus Terrestris Linn.

Khan, Shazia; Kabir, Hifzul; Jalees, Farhan; Asif, Mohd; Naquvi, Kamran Javed

doi:10.7439/ijbr.v2i1.79

Cited by 14 publications

(13 citation statements)

References 11 publications

(3 reference statements)

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“…This result partially matches with the evaluation from Sen et al, (2011); describing that, elevated serum TG level was decreased in extract and Sprulina treated group. Hypolipidemic activity may be due to the presence of phenolic compounds leading to increased lipoprotein lipases in the muscles and decreased activity in the adipose tissues, thus indicating that plasma triglycerides are utilized for energy production by the muscle and not for energy storage by the adipose tissue (Khan et al, 2011). Nugroho et al, (2014) estimated that Spirulina has significant lowering effect on triglyceride levels in high fructose fed diabetic rats in contrast to normal rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Spirulina platensis on alloxan induced diabetic rats

et al. 2018

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The study was undertaken to investigate the effects of Spirulina platensis on body weight, blood glucose and lipid profile on alloxan induced diabetic rats. Fifteen Long Evans male rats at six weeks of age were used for the experiment. Diabetes was induced by intraperitoneal injection of alloxan@ 150 mg/kg and experiment was carried out for a period of 6 weeks. Rats were divided into three groups of 5 rats each. The groups were i)healthy control, ii) diabetic control with both receiving rats’ pellet as supplement, and iii) diabetic treated with oral administration of Spirulina platensis @ 400 mg/kg bwt. Results from the study showed that Spirulina platensis reduced blood glucose significantly (P<0.01) and increased body weight significantly (P<0.05) in contrast to diabetic control group after 6 weeks. Lipid profile analysis with Spirulina platensis @ 400 mg/kg showed that total cholesterol, plasma triglycerides, and LDL were lowered significantly compared to diabetic groups in contrast to HDL levels which were increased following the use of Spirulina platensis. Our findings showed that oral administration of Spirulina platensis could reduce the adverse effect of alloxan induced diabetes in rats. Based on this research it can be concluded that Spirulina platensis has antihyperglycemic and hypolipidimic effects in alloxan induced diabetic rats.Progressive Agriculture 29 (2): 139-146, 2018

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Section: Discussionmentioning

confidence: 99%

Effects of Spirulina platensis on alloxan induced diabetic rats

et al. 2018

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“…Hypolipidemic activity may be due to the presence of phenolic compounds leading to increased lipoprotein lipases in the muscles and decreased activity in the adipose tissues, thus indicating that plasma triglycerides are utilized for energy production by the muscle and not for energy storage by the adipose tissue. [ 37 ] The pleotropic effect of TT at 5 mg/kg/day dose for 8 weeks on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed on a cholesterol-rich diet was studied. It was found that dietary intake of the herb significantly lowered the serum lipid profile, decreased endothelial cellular surface damage as well as ruptures, and partially repaired the endothelial dysfunction resulting from hyperlipidemia.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytopharmacological overview of Tribulus terrestris

et al. 2014

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Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, anti-inflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its value-added utility, eventually leading to higher revenues from the plant.

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“…TT is commonly used as medicinal herb in the treatment of various diseases in many countries. The induction of bone formation due to an increase in testosterone production [12] and hypolipidemic activities [25,44] have been reported as consequences of TT treatment in several studies. However, its effect is not known on BMD in cases caused by hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 99%

“…Medicinal plants are known to have an important impact on human health throughout in the world [22]. aphrodisiac [24], hypolipidemic [25],…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Tribulus terrestris, Avena sativa, and White Ginseng Powder on Bone Mineral Density in Hypercholesterolemic Rats

Akdoğan¹,

İlçe²,

Bilgili³

et al. 2019

JPP

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This study investigated the effects of the herbal compounds Tribulus terrestris (TT), Avena sativa (AS), white ginseng (WG), and a triple combination (TC) powder on the serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, and the tibial bone mineral density (BMD) levels in rats fed a high-cholesterol diet. This study comprised Group I (normal pellet feed), Group II (pellet feed with 2% cholesterol), Group III (2% cholesterol plus 15% TT), Group IV (2% cholesterol plus 7.5% AS), Group V (2% cholesterol plus 5% WG) and Group VI (2% cholesterol plus 7.5 TT% + 3.75% AS, 2.5% WG). The serum total cholesterol, LDL-C, HDL-C, triglyceride, and tibial BMD (g/cm 2) levels were measured. Significant decrease in the serum HDL-C levels in Group II than Group I, and significant increase in the serum LDL-C levels in Group II than Groups I and VI were determined. The tibial BMD levels were significantly lower in Groups II and IV than Group I. It was determined that WG and TC significantly prevented the serum total cholesterol increase; TC significantly prevented the serum LDL-C increase; and TT, WG, and TC were non-significantly effective in the improvement of tibial BMD levels.

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Antihyperlipidemic Potential of Fruits of Tribulus Terrestris Linn.

Cited by 14 publications

References 11 publications

Effects of Spirulina platensis on alloxan induced diabetic rats

Effects of Spirulina platensis on alloxan induced diabetic rats

Phytopharmacological overview of Tribulus terrestris

Protective Effects of Tribulus terrestris, Avena sativa, and White Ginseng Powder on Bone Mineral Density in Hypercholesterolemic Rats

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