Phytopharmacological overview of Tribulus terrestris

Abstract

Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, anti-inflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its value-added utility, eventually leading to higher revenues from the plant.

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

“…The antibacterial activity of ethanol extract from Turkish and Iranian T. terrestris has been confirmed against E. coli, P. aeruginosa, S. aureus and Enterococcus faecalis [1,3] while the Yemeni ones have showed no activity against four above mentioned bacteria [22]. Therefore, there are confusing reports about the antibacterial activities of T. terrestris.…”

“…As the traditional systems are shown, T. terrestris has been used from the ancient times as antimicrobial agents. In recent years, the antibacterial activities of T. terrestris extracts were confirmed against a large number of bacteria [1,[3][4][5], although the role of T. terrestris in management of urinary tract infections has not been studied yet.…”

Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines

“…It has anti-inflammatory, anticancer, antibacterial, and anticariogenic activities (3). This medicinal plant produces high levels of flavonoids, flavonol glycosides, steroidal saponins, and alkaloids (3). Tribulus terrestris has a preventive efficacy against Ultraviolet B (UVB)-induced carcinogenesis by scavenging free radicals and is capable of protecting cells against chemical and oxidative damage (4).…”

“…Tribulus terrestris fruits are used to treat edema, abdominal distention and sexual dysfunction. It has anti-inflammatory, anticancer, antibacterial, and anticariogenic activities (3). This medicinal plant produces high levels of flavonoids, flavonol glycosides, steroidal saponins, and alkaloids (3).…”

Pharmacognostical and Pharmaceutical Evaluation of Polyherbal Formulation Triphaladi Capsule With Seven Bhavana

“…Triphaladi capsule is a combination of above 11 dried herbs which was triturated seven times with the decoction of the same compound then after made dried powder and filled in 500 mg capsules. These all 11 drugs are known for their actions; like adaptogenic properties of Guduchi, Haritaki, Amalaki; 8 anti cataract activity of Haritaki, Amalaki, Bibheetaki (Triphala) 9 ; anti advanced glycated end products activity of Shunthi 10 ; antioxidants activity of Haridra, Amalaki, Yashtimadhu, Tulsi, Bibheetaki, Guduchi, Sunthi 11 ; adaptogenic, immunomodulatory and anti inflammatory properties of Punarnava 12 ; immunomodulatory and anti inflammatory properties of Gokshura 13 ; adaptogenic, anti inflammatory, anti cataract effect of Haridra 14 and anti inflammatory activity of Daruharidra 15 .…”