Pharmacognostical and Pharmaceutical Evaluation of Polyherbal Formulation Triphaladi Capsule With Seven Bhavana

Abstract

Haritaki, Bibheetaki, Amalaki, Yastimadhu, Gokshura, Guduchi, Haridra, Daruharidra, Shunthi and Punarnava are the potent Rasayana drugs mentioned in all the ancient classics of Ayurveda which improves the quality of life and delay the senile degenerative disorders. Bhavana (trituration) is an important Samskara (process) mentioned in classics by which even a small dose of a drug may be made very potent to produce a very high result. Triphaladi capsule is a combination of above 11 dried herbs which was triturated seven times. Aim of the study was to screen the differences in pharmacognostical and pharmaceutical profile of Triphaladi capsule prepared with seven Bhavana. The powder of Triphaladi compound was triturated with decoction of the same compound seven times and made into dried powder which was filled in capsules and subjected to pharmacognostical and pharmaceutical evaluation. After Bhavana significant changes were found in the form of disturbed collenchyma cells and cork cells of Guduchi, collapsed epicarp cells of Haritaki, fragmented fibres of Yastimadhu, disturbed pitted vessels of Yastimadhu etc. Also in analytical study changes like increase in water soluble extractive value, increase in ash value, increase in pH, increased number of HPTLC spots etc were noted.

[Retracted] Bhavana, an Ayurvedic Pharmaceutical Method and a Versatile Drug Delivery Platform to Prepare Potentiated Micro‐Nano‐Sized Drugs: Core Concept and Its Current Relevance

“…Bhavana plays an important role in the alteration of properties, incorporation of additional bioactive attributes to the drugs, and thus changing the therapeutic value of them. Although these changes can be perceived at pharmacognostical as well as phytochemical levels [59,[117][118][119][120][121][122], more studies are required on the fundamental understanding of the Bhavana process (mechanochemistry), the complex interplay between particle breakage kinetics and possible aggregation, overlapping of liquid media contents on solid particles, and the physical stability of the wet-grinded microparticles.…”