Effects of Spirulina platensis on alloxan induced diabetic rats

Abstract

The study was undertaken to investigate the effects of Spirulina platensis on body weight, blood glucose and lipid profile on alloxan induced diabetic rats. Fifteen Long Evans male rats at six weeks of age were used for the experiment. Diabetes was induced by intraperitoneal injection of alloxan@ 150 mg/kg and experiment was carried out for a period of 6 weeks. Rats were divided into three groups of 5 rats each. The groups were i)healthy control, ii) diabetic control with both receiving rats’ pellet as supplement, and iii) diabetic treated with oral administration of Spirulina platensis @ 400 mg/kg bwt. Results from the study showed that Spirulina platensis reduced blood glucose significantly (P<0.01) and increased body weight significantly (P<0.05) in contrast to diabetic control group after 6 weeks. Lipid profile analysis with Spirulina platensis @ 400 mg/kg showed that total cholesterol, plasma triglycerides, and LDL were lowered significantly compared to diabetic groups in contrast to HDL levels which were increased following the use of Spirulina platensis. Our findings showed that oral administration of Spirulina platensis could reduce the adverse effect of alloxan induced diabetes in rats. Based on this research it can be concluded that Spirulina platensis has antihyperglycemic and hypolipidimic effects in alloxan induced diabetic rats.Progressive Agriculture 29 (2): 139-146, 2018

Assessment of Chemical Composition of Spirulina Platensis and its Effect on Fasting Blood Glucose and Lipid Profile in Diabetic Rats

“…(28) Effect on lipid profile Diabetic rats exhibited a significant increase in serum TC, triglyceride and LDL-C when compared to normal control rats. This comes in agreement with Hussaini et al, (2018) (29) who reported that Alloxan causes hyperlipidemia in animals. In the current study, there was a significant reduction in serum TC, triglyceride and LDL-C and improvement in HDL-C of diabetic rats treated with different tested doses of Spirulina platensis as compared with diabetic control.…”

Antioxidant and Antihyperglycemic Activity of Arthrospira platensis (Spirulina platensis) Methanolic Extract: In vitro and In vivo Study

“…In this connection, diabetic rats treated with Spirulina maxima showed a regain in their body weight which may be explained by the increased insulin secretion or the increased food consumption (Pandey et al, 2010). Likewise, oral administration of S. platensis aqueous extract to diabetic rats for 50 days led to an obvious regain in their body weight loss, suggesting general health status and metabolic mechanisms improvement by effective control of glycemia or reversing of gluconeogenesis (Aissaoui et al, 2017;Hussaini et al, 2018).…”

“…The hypoglycemic effect of Spirulina maxima or S. platensis powder aids in the diabetes treatment by controlling the increased blood glucose levels in the streptozotocin (STZ) induced diabetic animals (Pandey et al, 2011;Ripa et al, 2018). Moreover, the administration of 400 mg/Kg of S. platensis powder could reduce the adverse effect of plasma hyperglycemia in the alloxan induced diabetic rats as recommended by Hussaini et al (2018) and Okechukwu et al (2019). The possible mechanism by which Spirulina brings about its antihyperglycemic action may be through improving the pancreatic secretion of insulin from β-cell islets or due to enhanced transportation of blood glucose to the peripheral tissue in the Spirulina -treated diabetic rats (El-Baz et al, 2013).…”

“…It is also a natural source for provitamin A and vitamins B12, E and C, as well as phenolic acids, linoleic acid, and phytopigments (El-Baz et al, 2013). These algal compounds act as antioxidant (Rady et al, 1994;Scaglioni et al, 2018;Saeed et al, 2020), antimicrobial (Gheda et al, 2013;El-Sheekh et al, 2014b;Metwally et al, 2020), antidiabetic (Hussaini et al, 2018;Okechukwu et al, 2019), antiinflammatory (Nasirian et al, 2018), anticancer (Zaid et al, 2015), antihyperlipidemic (Salem et al, 2014), and antiviral (Yakoot & Salem, 2012). In the literature, many studies reported the role of Spirulina as powder (Salem et al, 2014;Hussaini et al, 2018;Okechukwu et al, 2019) as antidiabetic agent in vivo.…”

Antioxidant and Antidiabetic Activity of Algae

“…In a recent study, diabetic rabbits, when fed with Arthrospira platensis (Cyanobacteria) powder, showed antihyperglycemic activity by lowering their blood glucose levels [106]. Moreover, the administration of 400 mg/Kg of A. platensis powder could reduce the adverse effect of hyperglycemia in the alloxan-induced diabetic rats [107]. Besides, the antioxidants compounds detected in A. platensis extract can aid to prevent diabetes or alleviate its adverse effects on blood parameters and the inflammatory phase [108].…”