Antihyperlipidemic and hepatic antioxidant effects of Leek leaf methanol extract in high fat diet-fed rats

Abstract

Hyperlipidemia and oxidative stress are major risk factors for the development of atherosclerosis and cardiovascular disease. This study was designed to investigate the hypolipidemic and hepatic antioxidant potentials of the methanol Leek extract (LE) in a high-fat diet (HFD)-fed rat model. Wistar rats were divided into 6 groups (n = 6/groups) as 1) control fed standard diet, 2) HFD, 3) HFD + (Atorvastatin) (20 mg/kg), and HFD + LE (100, 200, or 300 mg/kg). All treatments were administered by gavage and conducted for 6 weeks, daily. At all tested, but in a dose-independent manner, LE significantly reduced final body weights and food intake and suppressed serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Besides, in inhibited serum and hepatic levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C) but increased serum and hepatic levels of high-density lipoprotein cholesterol (HDL-C). Concomitantly, LE, at all tested doses increased the activity of superoxidase dismutase (SOD) and glutathione peroxidase (GPx), increased the levels of catalase (CAT) and decreased the levels of malondialdehyde (MDA) in the livers of HFD-fed rats. In conclusion, LE exerts potent hypolipidemic and hepatic antioxidant potentials in HFD-fed rats which highlight its beneficial effects in various metabolic-related disorders.

Secoisolariciresinol diglucoside and anethole ameliorate lipid abnormalities, oxidative injury, hypercholesterolemia, heart, and liver conditions

“…Treatment with atorvastatin, anethole, and secoisolariciresinol diglucoside (SDG) derived from fennel seed and flaxseed all improved lipid profiles by significantly lowering TC, TG, and LDL‐C levels and significantly elevating serum HDL‐C, the latter of which became more noticeable after 6 weeks of treatment, as shown in Table 2 . This observation agrees with other studies (Al‐Otaibi et al, 2020 ). This study demonstrated that anethole and SDG therapy may directly influence lipid metabolism, as anethole (10 mg/kg/day), SDG (10 mg/kg/day), and their combined dose (10 + 10 mg/kg/day) prevent hypercholesterolemia and hypertriglyceridemia, respectively, and reduce levels of free fatty acids and TG in hyperlipidemic subjects through their potent lipolytic activity.…”

Achillea Fragrantissima Ethanolic Extract Exerts Hypocholesterolemia and Hepatic Antioxidant Effects in High Fat-Cholesterol Diet: An Experimental Study

“…After 8 weeks blood samples were collected for measuring the lipid profile parameters. Rats with hypercholesterolemia as defined by Kalsoom and Jafari 28 were randomly assigned into four groups (10 each) HFCD; hypercholesterolemic rats fed HFCD and given orally 1 ml of saline daily; HFCD+AF; hypercholesterolemic rats fed HFCD and received concomitant treatment with an oral dose of AF extract (500 mg/kg animal weight (AW)) 24 ; HFCD+ ATOR; hypercholesterolemic rats fed HFCD and received concomitant treatment with Atorvastatin (ATOR) as a reference drug (20 mg/kg AW) 29 ; and HFCD+ AF+ ATOR; hypercholesterolemic rats fed HFCD and received concomitant treatment with AF extract and ATOR. The rats were given different treatments for four consecutive weeks; rats in the Cont group were orally given saline for 4 weeks.…”

Antihyperlipidemic and Antioxidant Activity of Syzygium Aromaticum Extract in Rats Fed Cycas Diet

“…23,24 Animal have an effective mechanism to inhibit tissue damage caused by free radical which induces oxidative stress through the help of antioxidant enzymes and protein such as SOD, CAT, GPX and GSH. 25 Table 2 shows the GSH level in the blood and liver of cycas fed rats. There was a significantly (p < 0.05) lower GSH levels in liver and blood of rats fed with cycas diet only compared with rats fed the normal diet.…”

“…The significant increase in TC and TAG level in rats of cycas control compared with normal control may be due de novo lipid synthesis. According to Al-Otaibi et al 25 the combined effect of lipid degradation and de novo lipid synthesis induced by oxidative stress could be an attempt to meet lipid requirements for growth and metabolism. Values are represented in mean ± SD, n = 5.…”