Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats

Vijayaraj, Panneerselvam; Muthukumar, Kaliappan; Jayaraja, Sabarirajan; Nachiappan, Vasanthi

doi:10.1016/j.etp.2011.07.001

Cited by 54 publications

(37 citation statements)

References 39 publications

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“…However, the administration of the Piper betle extract or eugenol significantly decreased the blood glucose levels in hypercholesterolemic rats. These results are consistent with those of an earlier study in which an extract of the flower of Cassia auriculata significantly decreased serum glucose levels in hyperlipidemic rats [37]. …”

Section: Discussionsupporting

confidence: 93%

“…Triton WR-1339-induced hypercholesterolemia has been demonstrated to alter the physicochemical properties of lipoproteins, thereby preventing the uptake of lipoproteins from the circulation through extra hepatic tissues resulting in increased level of circulatory lipoproteins in animal models [34]. Triton WR-1339 model being a rapid and convenient system [18] has been extremely employed for screening natural [35–37] or chemical hypolipidemic drugs [38–40] and also to delineate features of cholesterol and triacylglycerol metabolism [41]. In addition, Triton WR-1339 has also been used successfully to study intestinal lipoprotein synthesis in animal models [42].…”

Section: Discussionmentioning

confidence: 99%

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Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR‐1339‐Induced Hypercholesterolemia in Experimental Rats

Venkadeswaran

Muralidharan

Thangaraj

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Hypercholesterolemia is a dominant risk factor for atherosclerosis and cardiovascular diseases. In the present study, the putative antihypercholesterolemic and antioxidative properties of an ethanolic extract of Piper betle and of its active constituent, eugenol, were evaluated in experimental hypercholesterolemia induced by a single intraperitoneal injection of Triton WR-1339 (300 mg/kg b.wt) in Wistar rats. Saline-treated hypercholesterolemic rats revealed significantly higher mean blood/serum levels of glucose, total cholesterol, triglycerides, low density and very low density lipoprotein cholesterol, and of serum hepatic marker enzymes; in addition, significantly lower mean serum levels of high density lipoprotein cholesterol and significantly lower mean activities of enzymatic antioxidants and nonenzymatic antioxidants were noted in hepatic tissue samples from saline-treated hypercholesterolemic rats, compared to controls. However, in hypercholesterolemic rats receiving the Piper betle extract (500 mg/kg b.wt) or eugenol (5 mg/kg b.wt) for seven days orally, all these parameters were significantly better than those in saline-treated hypercholesterolemic rats. The hypercholesterolemia-ameliorating effect was better defined in eugenol-treated than in Piper betle extract-treated rats, being as effective as that of the standard lipid-lowering drug, lovastatin (10 mg/kg b.wt). These results suggest that eugenol, an active constituent of the Piper betle extract, possesses antihypercholesterolemic and other activities in experimental hypercholesterolemic Wistar rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR‐1339‐Induced Hypercholesterolemia in Experimental Rats

Venkadeswaran

Muralidharan

Thangaraj

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Free radical scavenging enzymes such as SOD, CAT, and GPx are the first line of cellular defense against oxidative injury and are involved in the disposal of superoxide anions, hydrogen peroxide, and so forth, and pronounced alterations were observed during hyperlipidemic conditions in rats [27]. The increased SOD levels after administration of the extracts can be attributed to the large amounts of ascorbic acid present in the plant which was confirmed during the preliminary phytochemical screening.…”

Section: Discussionmentioning

confidence: 90%

Antihyperlipidemic and Antioxidant Potential of Paeonia emodi Royle against High-Fat Diet Induced Oxidative Stress

et al. 2014

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The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). The plant was extensively examined for its in vitro antioxidant activity, and the preliminary phytochemical screening was carried out using standard protocols. Male Wistar rats were induced with hyperlipidemia using high-fat diet and were treated orally with hydroalcoholic and aqueous extracts at the dose of 200 mg/kg bw for 30 days. TGs, TC, LDL-c, and AI were significantly reduced while HDL-c, SOD, and GPx levels rose to a considerable extent. After subjecting to acute toxicity testing, the extracts were found to be safe. The observations suggest antihyperlipidemic and antioxidant potential of P. emodi in high-fat diet induced hyperlipidemic/oxidative stressed rats.

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“…In the present study, pretreatment with PA significantly inhibited the production of MDA in a dose-dependent manner, which alleviated oxidative stress in the lung tissues of mice with ALI. Furthermore, tissues may escape ROS-induced toxic damage via ROS scavenging enzymes, including SOD and GPx, which are the first-line cellular defense against oxidative injury (17,56). The equilibrium between these enzymes and ROS is important for the effective removal of oxidative stress from intracellular organelles (57).…”

mentioning

confidence: 99%

Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide-induced acute lung injury in mice

Liao

Liu

et al. 2015

Experimental and Therapeutic Medicine

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Patchouli alcohol (PA) is a tricyclic sesquiterpene isolated from Pogostemon cablin, which exerts anti-inflammatory, anti-influenza and cognitive-enhancing bioactivities. The present study aimed to investigate the protective effects of PA on acute lung injury (ALI) induced by intratracheal instillation of lipopolysaccharide (LPS) in mice. Dexamethasone was used as a positive drug for protection against LPS-induced ALI. The results of the present study demonstrated that pretreatment with PA significantly increased survival rate, attenuated histopathologic damage and lung edema, and decreased the protein content in the bronchoalveolar lavage fluid (BALF) of mice with ALI. Furthermore, PA significantly inhibited the expression levels of proinflammatory cytokines, including tumor necrosis factor (TNF)-α and interleukin (IL)-6 in the BALF, downregulated the levels of myeloperoxidase and malondialdehyde, and upregulated the activity levels of superoxide dismutase and glutathione peroxidase in lung tissue. These results indicated that PA may exert potent protective effects against LPS-induced ALI in mice, the mechanisms of which are possibly associated with the anti-inflammatory and antioxidative activities of PA.

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Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats

Cited by 54 publications

References 39 publications

Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR‐1339‐Induced Hypercholesterolemia in Experimental Rats

Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR‐1339‐Induced Hypercholesterolemia in Experimental Rats

Antihyperlipidemic and Antioxidant Potential of Paeonia emodi Royle against High-Fat Diet Induced Oxidative Stress

Protective effects of patchouli alcohol isolated from Pogostemon cablin on lipopolysaccharide-induced acute lung injury in mice

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