Antihyperlipidemic and Antioxidant Potential of Paeonia emodi Royle against High-Fat Diet Induced Oxidative Stress

Abstract

The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). The plant was extensively examined for its in vitro antioxidant activity, and the preliminary phytochemical screening was carried out using standard protocols. Male Wistar rats were induced with hyperlipidemia using high-fat diet and were treated orally with hydroalcoholic and aqueous extracts at the dose of 200 mg/kg bw for 30 days. TGs, TC, LDL-c, and AI were significantly reduced while HDL-c, SOD, and GPx levels rose to a considerable extent. After subjecting to acute toxicity testing, the extracts were found to be safe. The observations suggest antihyperlipidemic and antioxidant potential of P. emodi in high-fat diet induced hyperlipidemic/oxidative stressed rats.

Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

“…ER stress-signaling pathways regulated by GRP78, leading to UPR survival, cell fate and apoptosis responses [45]. ER stress induces XBP-1 to produce a more active transcription factor [46].…”

Changes in the Oxidative Stress Biomarkers in Liver of Streptozotocin-diabetic Rats Treated with Combretum lanceolatum Flowers Extract

“…Finally, it must be highlighted that the presence of antioxidants and their effective in vitro scavenging capacities are also positively correlated with the protective effects of plant extracts against various disturbances, such as prevention of cell damage caused by UV light exposure [51], antineoplastic effects on tumor cell lines [52,53], reduction of the oxidative stress in animals models of hyperlipidemia [54,55] and liver injuries [56,57], among others.…”

Evaluation of the protective effect of Paeonia emodi Wall on rat model of Parkinson’s disease induced by 6 hydroxy dopamine

“…19 Apart from this in-vitro study, invivo studies conducted by Zaidi et al, in pentylenetetrazol (PTZ) induced epilepsy and Zargar et al, in high fat dietinduced oxidative stress model have demonstrated antioxidant activity of PEW. 9,20 The doses of the PEW, 200mg/kg/b.w. (low dose, LD) and 300mg/kg/b.w.…”

“…This antioxidant effect of ethanolic extract of PEW is also supported by previous studies in vitro as well in vivo studies. 9,19 It is reported that on intra-striatal administration of 6hydroxydopamine, the dopaminergic neurons are specifically degenerated by increased oxidative stress and apoptosis. PEW in higher dose showed protective effect on striatal neurons with clear texture of striatal tissue.…”

“…7 Phytochemical studies have demonstrated the presence of various bioactive compounds like phenolics, oligostilbenes and flavonoids in the roots of PEW. 9 Flavonoids in PEW react with the reactive radical resulting in more stable, less reactive radical, thus exerting antioxidant properties to it. 7 Many of the local and traditional claims for the use of different parts of PEW have been scientifically established by in vivo and in vitro methods.…”