2011
DOI: 10.1016/s1995-7645(11)60193-4
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Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves (field grown & in vitro raised) extracts on alloxan induced diabetic rats

Abstract: From the results it can be concluded that the leaves extracts of S. xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress.

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Cited by 73 publications
(53 citation statements)
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“…In this context, a number of other plants have also been reported to exert hypoglycemic activity through insulin release stimulatory effect [33,34] . Decreased body weight observed in diabetic control rats in comparison to normal rats indicates that loss of body weight is a result of excessive breakdown of tissue proteins [35][36][37][38][39][40][41] . Treatment with M. emarginata improved body weight to a certain extent, indicating that control over muscle wasting resulted from glycemic control.…”
Section: Discussionmentioning
confidence: 95%
“…In this context, a number of other plants have also been reported to exert hypoglycemic activity through insulin release stimulatory effect [33,34] . Decreased body weight observed in diabetic control rats in comparison to normal rats indicates that loss of body weight is a result of excessive breakdown of tissue proteins [35][36][37][38][39][40][41] . Treatment with M. emarginata improved body weight to a certain extent, indicating that control over muscle wasting resulted from glycemic control.…”
Section: Discussionmentioning
confidence: 95%
“…Nitric oxide reacts with free radicals, thereby producing the highly damaging peroxynitrite. Nitric oxide injury takes place for the most part through the peroxynitrite route because peroxynitrite can directly oxidize LDLs, resulting in irreversible damage to the cell membrane [19][20][21][22][23][24][25] . Hence, various extract from L. camara could be used to overcome various health problem causes by nitric oxide injury.…”
Section: Discussionmentioning
confidence: 99%
“…A number of studies revealed that oxidative stress plays a major role in the development, progression of diabetes and its related complications [30][31][32][33][34][35][36][37][38][39] . In diabetic state, free radical generation may occur via increased glycolysis, intercellular activation of polyol pathway, auto-oxidation of glucose and non-enzymatic protein glycation [40] .…”
Section: Discussionmentioning
confidence: 99%