Antihyperglycemic and anti-oxidant activity of various fraction of <i>Parmotrema hababianum</i> in streptozotocin-induced diabetic rat

Abstract

&lt;p class="Abstract"&gt;The core objective of this study was to investigate the in vitro anti-oxidant and antihyperglycemic effect of the ethanol extract of &lt;em&gt;Parmotrema &lt;/em&gt;hababianum in streptozocin-induced diabetic rats for 42 days. The extract showed nearly all anti-oxidant activities with maximum presence. The treatment with extract in diabetic rats at the dosage level of 100 and 200 mg/kg, which is compared with diabetic control and glibenclamide at a dosage level of 4 mg/kg and the biochemical parameters such as blood glucose, total cholesterol, triglycerides, HDL, LDL, insulin, total protein, urea and creatinine were assessed. The extract showed positive correlation (p&amp;lt;0.001) in reducing blood glucose level as compared to the control. Moreover, there was a significant (p&amp;lt;0.01) decrease in TC, TG, LDL, SGPT, SGOT, urea and creatinine level and significant (p&amp;lt;0.01) increase in HDL and insulin level. Thus, the results of this study show considerable efficacy in curing diabetes with potent anti-oxidant and anti-hyperglycemic activity.&lt;/p&gt;&lt;p class="Abstract"&gt;&lt;strong&gt;Video Clip of&lt;/strong&gt;:&lt;/p&gt;&lt;p class="Abstract"&gt;&lt;a href="https://youtube.com/v/Lw2vvLpKNTE"&gt;Methodology&lt;/a&gt;: 6 min 12 sec&lt;/p&gt;

Metabolite Profiling and in Vitro Assessment of Antimicrobial and Antioxidant Activities of Lichen Ramalina Inflata

“…Lichens are known for their high phenolic content which is also a reason why they have varied biological applications 27 . This is due to the redox properties of their hydroxyl groups which make them as strong antioxidants 28 .…”

Taxithelium napalense acts against free radicals and diabetes mellitus

“…As earlier mentioned, the demand for identification of new drugs from natural products gaining day by day (Mohan et al, 2014;Emeka et al, 2015;Rehman et al, 2015;Ganesan et al, 2016), current research was carried on moss, T. napalense and it is initial reports on phytochemical analysis, antioxidant capacity and antidiabetic capacity. There were some earlier reports on different biological activities on bryophytes including mosses (Laura et al, 2015;Vizma et al, 2012) but there was no reports on T. napalense.…”

“…The demand on natural antidiabetic preparations/ products is gaining interest due to undesirable side effects, toxicity and high cost of synthetic drugs (oral hypoglycemic drugs) and insulin (Mohan et al, 2014;Emeka et al, 2015;Rehman et al, 2015;Ganesan et al, 2016).…”

Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review

“…The in vivo antidiabetic studies of three lichen extracts, namely, Cladonia humilis [ 43 ], Parmotrema grayana [ 44 ] and P. hababianum [ 45 ] have been described to prove the in vivo antidiabetic potential of lichens.…”

“…Further confounding the available information, compared to the antioxidant potential, limited information exists on evaluation of the efficacy of lichens as antidiabetic agents. A number of different approaches have been used, including α -amylase inhibitory [ 27 – 34 ], α -glucosidase [ 35 , 36 ], and PT1B inhibitory activity [ 37 – 40 ], antiglycation [ 41 , 42 ], along with a few in vivo studies to identify the potential of lichens in treating DM [ 43 – 45 ].…”