Antihistaminic and other biological activities of 2-methylpropanamide and benzamide derivatives of carboxyterfenadine

Comparative Study of Chemical Stability of Two H1Antihistaminic Drugs, Terfenadine and ItsIn VivoMetabolite Fexofenadine, Using LC-UV Methods

“…As a consequence, its chemical stability has not been studied so far. However, in the literature, there are reports showing new therapeutic recommendations for TER in view of its anticholinergic, antiviral, and anticancer activities [6–10]. In addition, there are still attempts to obtain new derivatives of TER and FEX with higher activities and lower side effects [3].…”

“…The research in the field of antihistaminic activity of different compounds is continuous ongoing study, and some reports concerning novel analogues of TER and FEX are present in the literature. In addition, TER was shown to manifest additive biological effects such as anticholinergic or antiviral activities [6–8]. Based on these results, a series of TER derivatives was prepared in order to increase these activities and to derive new structure-activity relationships [7, 8].…”