Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa

Gadgoli, Chhaya; Mishra, S.H.

doi:10.1016/s0378-8741(98)00229-3

Cited by 120 publications

(78 citation statements)

References 6 publications

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“…spinosa L. has a variety of pharmacological activities and is used in phytomedicine around the world for its anti-oxidative, 16) antifungal, 17) antihepatotoxic, 18) anti-in‰ammatory 19) and anti-diabetic eŠects. 20,21) But, the eŠect of C. spinosa L. extract on rheumatoid arthritis has not been demonstrated experimentally.…”

Section: Discussionmentioning

confidence: 99%

Anti-arthritic Active Fraction of <i>Capparis Spinosa</i> L. Fruits and Its Chemical Constituents

Xin

et al. 2011

YAKUGAKU ZASSHI

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The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic eŠects of diŠerent fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50：50, v/v) had the most signiˆcant anti-arthritic activity. The chemical constituents of this fraction were therefore studied; seven known compounds were isolated and identiˆed as: (1) P-hydroxy benzoic acid; (2) 5-(hydroxymethyl) furfural; (3) bis (5-formylfurfuryl) ether; (4) daucosterol; (5) a-D-fructofuranosides methyl; (6) uracil; and (7) stachydrine.

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Section: Discussionmentioning

confidence: 99%

Anti-arthritic Active Fraction of <i>Capparis Spinosa</i> L. Fruits and Its Chemical Constituents

Xin

et al. 2011

YAKUGAKU ZASSHI

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“…Fruits with small, soft seeds are preferred for the production of pickles (Özcan & Aydin, 2004;Matthäus & Ozcan, 2005). C. spinosa is used in phytomedicine around the world as an antihyperglycemic (Eddouks et al, 2004), antihepatotoxic (Eddouks et al, 2005;Gadgoli & Mishra, 1999), antioxidant (Germano et al, 2002;Steenkamp et al, 2004), antifungal (Ali-Shtayeh & Abu Ghdeib, 1999), anti-inflammatory (Al-Said et al, 1988) and antidiabetic (Eddouks et al, 2004;Yaniv et al, 1987). In China, C. spinosa has been used since ancient times in traditional medicine especially for the treatment of rheumatism and gout (Fu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A new antioxidant compound fromCapparis spinosa

Yang¹,

Wang

Liu

et al. 2010

Pharmaceutical Biology

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“…In a study on rats by Gadgoli et al (12), the effect of Capparis spinosa was researched against liver damage induced with carbon tetrachloride (CCl 4 ) and paracetamol. There was a statistically significant decrease in AST, ALT, ALP, and T. Bil.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol

et al. 2016

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Background/aim: To investigate the efficiency of Capparis ovata as a protective agent against acute paracetamol toxicity of the liver. Materials and methods:A total of 36 Wistar albino rats were divided into 4 groups: 1) paracetamol, 2) Capparis ovata + paracetamol, 3) Capparis ovata, and 4) control. Groups 2 and 3 were given Capparis ovata and Groups 1 and 4 distilled water for 8 days. On day 8, 3000 mg kg -1 paracetamol was administered orally to Groups 1 and 2. Samples were taken on day 9. AST, ALT, total bilirubin, direct bilirubin, GGT, and ALP levels were assessed. Lipid peroxidation markers and thiobarbituric acid-reactive substance (TBARS) levels were measured in the blood and liver. Liver tissues were evaluated histologically.Results: AST, ALT, and total bilirubin levels were lower in Group 2 than in Group 1 (P < 0.05). TBARS levels were lower in Groups 2 (P = 0.000), 3 (P = 0.001), and 4 (P = 0.001) than in Group 1. Degenerative findings were lower in the Capparis ovata + paracetamol group than in the paracetamol group (P < 0.05). Conclusion:It can be concluded that Capparis ovata has a protective effect on the liver, both histopathologically and biochemically, against paracetamol-induced liver injury.

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Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa

Cited by 120 publications

References 6 publications

Anti-arthritic Active Fraction of <i>Capparis Spinosa</i> L. Fruits and Its Chemical Constituents

Anti-arthritic Active Fraction of <i>Capparis Spinosa</i> L. Fruits and Its Chemical Constituents

A new antioxidant compound fromCapparis spinosa

The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol

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