Anti-arthritic Active Fraction of &lt;i&gt;Capparis Spinosa&lt;/i&gt; L. Fruits and Its Chemical Constituents

Xu, Feng; Lu, Jincai; Xin, Hailiang; Zhang, Lei; Wang, Yuliang; Tang, Kexuan

doi:10.1248/yakushi.131.423

Cited by 51 publications

(40 citation statements)

References 19 publications

(15 reference statements)

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“…These results strongly demonstrate the feasibility of using HMF as a candidate for sickle cell therapies. Furthermore, an analysis of chemical constituents present within an anti-arthritic fraction of Capparidaceae fruits was performed, confirming the presence of HMF, suggesting that it may play a major role as an anti-arthritic drug (114).…”

Section: Furan Components From Cellulose and Hemicellulosementioning

confidence: 81%

Biological activities of lignin hydrolysate-related compounds

Lee¹,

Monnappa²,

Mitchell³

2012

BMB Reports

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Section: Furan Components From Cellulose and Hemicellulosementioning

confidence: 81%

Biological activities of lignin hydrolysate-related compounds

Lee¹,

Monnappa²,

Mitchell³

2012

BMB Reports

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“…[52] Ethanol and ethanolwater extracts of Capparis spinosa L. (Capparidaceae) fruits showed anti-arthritic effects due to the presence of few important chemical constituents such as P-hydroxy benzoic acid; 5-(hydroxymethyl) furfural; bis (5-formylfurfuryl) ether; daucosterol; α-D-fructofuranosides methyl; uracil; and stachydrine. [53] Few plant species such as Aloe vera is used to treat arthritis. Regular use of its crude juice and gel is very efficient for relieving arthritic pain.…”

Section: Saponinsmentioning

confidence: 99%

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Upadhyay

2016

IJGP

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The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician' advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund's complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diagnosis, proper treatment, and healthy dietary habits can reduce the disease spectrum and chronic inflammatory pain.

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“…The anti-nociceptive and anti-inflammatory properties of Capparis are described in different animal models (Arslan et al, 2010;Zhou et al, 2010). In particular, flowering buds and fruits of Capparis spinosa have shown significant anti-inflammatory and anti-oxidant effects in both in vivo and in vitro model of articular damage (Feng et al, 2011;Panico et al, 2005). Even though the aerial parts of the plant, such as flowers, leaves and fruits are rather studied, less attention has been devoted to the roots of Capparis spinosa.…”

Section: Introductionmentioning

confidence: 99%

Acute effect of Capparis spinosa root extracts on rat articular pain

Maresca

Micheli

Mannelli

et al. 2016

Journal of Ethnopharmacology

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a b s t r a c tEthnopharmacological relevance: Capparis spinosa L. originates from dry regions of Asia and Mediterranean basin. In traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains. Aim of the study: To evaluate the pain relieving properties of a Syrian cultivar of Capparis spinosa roots in rat models of osteoarthritis and rheumatoid arthritis. Materials and methods: Decoction (DEC) and hydroalcoholic extract (EtH 2 O) were obtained from powdered roots; the latter was further separated in CH 2 Cl 2 and aqueous (H 2 O-Res) fractions. The extracts were characterized in terms of spermidine alkaloids by HPLC/DAD/MS and stachydrine by NMR. Different amount of free and glycosilated forms of capparispine and analogues (from 0.5% w/w for DEC up to 7.6% w/w for CH 2 Cl 2 fraction) were detected. Rat models of rheumatoid arthritis and osteoarthritis were induced by the intra-articular administration of Complete Freund's Adjuvant (CFA) or monosodium iodoacetate (MIA), respectively. Results: Fourteenth days after CFA or MIA injection, the different preparations of Capparis spinosa (3, 30, 100 and 300 mg kg À 1 ) were acutely administered p.o.. Powdered roots (300 mg kg ) significantly reduced hypersensitivity to mechanical noxious stimuli as well as spontaneous pain evaluated as hind limb bearing alterations in both models. The CH 2 Cl 2 and the H 2 O-Res (30 mg kg À 1 ) were the most potent in reverting pain threshold alterations despite the different content of free alkaloids. Conclusions: Capparis spinosa extracts relieved pain related to rheumatoid arthritis and osteoarthritis after single administration. A synergistic effect due to a specific "phytochemical mixture" is suggested.

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Anti-arthritic Active Fraction of <i>Capparis Spinosa</i> L. Fruits and Its Chemical Constituents

Cited by 51 publications

References 19 publications

Biological activities of lignin hydrolysate-related compounds

Biological activities of lignin hydrolysate-related compounds

Untitled

Acute effect of Capparis spinosa root extracts on rat articular pain

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