The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol

Doğan, Nurcan; Akçam, Mustafa; Koca, Tuğba; Doğuç, Duygu Kumbul; Özgöçmen, Meltem

doi:10.3906/sag-1409-40

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Blood was collected in heparinized tubes and stored at −20 • C, and the brain, kidney, and liver were collected and snap frozen for further analysis. High doses of APAP were used to ensure toxicity in liver, kidney, and brain, as shown by previous studies [36][37][38]. Additionally, high doses of vitamin E were used to measure pre-and post-treatment protective effects as reported previously [39][40][41].…”

Section: Methodsmentioning

confidence: 99%

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats

Hammad

Shawaqfeh

Hikmat

et al. 2023

Toxics

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Paracetamol (acetaminophen, APAP) is the most common non-prescription analgesic drug used during pregnancy. The aim of this study was to investigate the effect of vitamin E on acute APAP toxicity in pregnant rats. Toxicity in the liver, kidney, and brain (hippocampus, cerebellum, and olfactory bulb) was examined. Twenty pregnant female Wistar rats at gestational day 18 were used. Pregnant rats were divided into four groups: Control, APAP, E + APAP, and APAP + E. The Control group was treated with 0.5 mL p.o. corn oil. The APAP group received 3000 mg/kg p.o. APAP. The E + APAP group received 300 mg/kg p.o. vitamin E one hour before 3000 mg/kg APAP. The APAP + E group received 3000 mg/kg paracetamol one hour before 300 mg/kg p.o. vitamin E. Twenty-four hours after the last treatment administration, rats were euthanized and blood, brain, liver, and kidney samples were collected. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine levels, uric acid (UA), and superoxide dismutase (SOD) levels, as well as the relative mRNA expression of Cyp1a4, Cyp2d6, and Nat2, were determined. Acute APAP treatment upregulated ALT, AST, BUN, and creatinine levels. APAP treatment downregulated UA and SOD levels. APAP treatment upregulated the relative mRNA expression of Cyp1a4 and Cyp2d6, but downregulated Nat2 expression. Vitamin E treatment, either before or after APAP administration, attenuated the toxic effects of APAP. In conclusion, the results showed that an acute toxic APAP dose in late pregnancy can cause oxidative stress and dysregulation in Cyp isoform expression, and that vitamin E treatment attenuates these effects.

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Section: Methodsmentioning

confidence: 99%

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats

Hammad

Shawaqfeh

Hikmat

et al. 2023

Toxics

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Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations

et al. 2023

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Original article Biochemical and histologic evaluation following multiple dose administration of paracetamol alone and along with polyherbal extract mixture in rats

Bhadarka¹,

Patel²,

Ahmed³

et al. 2018

Ann. Phytomed

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The present experiment was carried out to investigate the amelioration of paracetamol (500 mg/ kg, PO) induced biochemical and pathological alterations by polyherbal extract mixture (PHEM) at 100, 200 and 300 mg/kg, PO and silymarin (10 mg/kg, PO) in rats. Symptoms of paracetamol toxicity were not observed in rats of any groups. No significant alterations in Hb, PCV, TEC, TLC, MCV, MCHC, MCH and DLC have been observed in rats of any group. Administration of paracetamol damaged the liver as shown with increased level of ALT, AST and total bilirubin, which were significantly lowered when rats treated with either PHEM or silymarin at 200 and 300 mg/kg orally for 21 days. The LDH level was also altered by paracetamol treatment which was observed unaltered in rats, treated with PHEM at all doses used in the study. The levels of blood urea nitrogen were also lowered in rats treated with PHEM at 200 mg/kg and 300 mg/kg compared to paracetamol control rats. The creatinine level in paracetamol was not altered in animals of different groups. The levels of total protein, albumin, globulin and uric acid were not altered significantly by paracetamol a dministra tion. The PHE M more than 200 mg/kg produ ced a protective effect against the damage of liver and kidney caused by paracetamol in rats.

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The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol

Cited by 3 publications

References 15 publications

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats

Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations

Original article Biochemical and histologic evaluation following multiple dose administration of paracetamol alone and along with polyherbal extract mixture in rats

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