Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

Siddique, Yasir Hasan; Ara, Gulshan; Beg, Tanveer; Afzal, Mohammad

doi:10.1007/s11418-006-0108-5

Cited by 9 publications

(3 citation statements)

References 30 publications

(39 reference statements)

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“…In fact, Nikolic et al [41] reported that plant terpenes exhibited antigenotoxic activty. On the other hand Siddique et al [42] demonstrated that a phenolic lignan (nordihydroguaiaretic acid), possesses an antigenotoxic potential against chlormadinone acetate induced genotoxic damage in mice bone-marrow cells.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts

Chaabane

Boubaker

Loussaif

et al. 2012

BMC Complement Altern Med

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BackgroundPlants play a significant role in maintaining human health and improving the quality of human life. They serve humans well as valuable components of food, as well as in cosmetics, dyes, and medicines. In fact, many plant extracts prepared from plants have been shown to exert biological activity in vitro and in vivo. The present study explored antioxidant and antigenotoxic effects of Daphne gnidium leaf extracts.MethodsThe genotoxic potential of petroleum ether, chloroform, ethyl acetate, methanol and total oligomer flavonoid (TOF) enriched extracts from leaves of Daphne gnidium, was assessed using Escherichia coli PQ37. Likewise, the antigenotoxicity of the same extracts was tested using the “SOS chromotest test”. Antioxidant activities were studied using non enzymatic and enzymatic method: NBT/Riboflavine and xantine oxidase.ResultsNone of the different extracts produced a genotoxic effect, except TOF extract at the lowest tested dose. Our results showed that D. gnidium leaf extracts possess an antigenotoxic effect against the nitrofurantoin a mutagen of reference. Ethyl acetate and TOF extracts were the most effective in inhibiting xanthine oxidase activity. While, methanol extract was the most potent superoxide scavenger when tested with the NBT/Riboflavine assay.ConclusionsThe present study has demonstrated that D. gnidium leaf extract possess antioxidant and antigenotoxic effects. These activities could be ascribed to compounds like polyphenols and flavonoid. Further studies are required to isolate the active molecules.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts

Chaabane

Boubaker

Loussaif

et al. 2012

BMC Complement Altern Med

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“…It is also thought that the decrease in the total number of individuals of D. melanogaster subject to applications of CMA at different concentrations is a result of the genotoxic effect of CMA. Sidduge et al, (2008) have determined that CMA has genotoxic and cytotoxic effects on bone marrow of mice and that these effects can be eliminated by the scavenging effect of NDGA on hydroxyl radicals, superoxide anions, singlet oxygen and hypochlorous acids (Siddique et al, 2008). With such features NDGA is accepted as a powerful antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid

et al. 2010

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In this study, the effects of chlormadinon acetate (CMA) and CMA + nordihydroguaiaretic acid (NDGA) on various developmental stages of Drosophila melanogaster were investigated. Different concentrations of CMA (1.0; 3.0; 5.0 and 10.0 μM/100 mL medium) and CMA + NDGA as the concentrations of CMA (1.0 + 1.0; 3.0 + 3.0; 5.0 + 5.0 and 10.0 + 10.0 μM/100 mL medium) were carried out during the developmental periods of the flies. When F(1) progeny of control and application groups were compared, CMA was found to extend the process of metamorphosis and decrease the total offspring numbers. However, these negative effects were inhibited by NDGA treatment at different concentrations. These results suggest that NDGA could effectively inhibit CMA-induced abnormalities in developmental stages of D. melanogaster. It was found that the difference between the groups was significantly important (p < 0.05).

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“…Prolonged use of estrogens has been reported to develop various types of malignancies in human and experimental animals [15]. The genotoxic effects of estrogens/ proges tins can be reduced by the use of antioxidants [16][17][18][19][20][21][22] and natural plant products [23][24][25][26][27][28]. The genotoxicity testing provides human a risk assessment.…”

Section: Introductionmentioning

confidence: 99%

Effect ofCentella asiaticaL. extract against ethinylestradiol-induced geno-toxic damage on cultured human lymphocytes

Siddique¹,

Beg²,

Afzal³

2009

Biomed Res

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In this study the effect of Centella asiatica L. extract was studied against genotoxic doses of ethinylestradiol on human lymphocytes culture. The different doses of C. asiatica L. extract i.e. 1.075x10 -4 , 2.125x10 -4 and 3.15x10 -4 g/ml were treated separately with 5 µM of ethinylestradiol. Similar treatments were given with 10 µM of ethinylestradiol. The treatments result in a significant dose dependent decrease in chromosomal aberrations and sister chromatid exchanges on human lymphocyte cultures induced by 5 and 10 µM of ethinylestradiol. The selected doses of C. asiatica L. extract were not genotoxic itself. Hence it is concluded that C. asiatica L. extract reduced the genotoxic damage during the ethinylestradiol therapy in patients and thereby reducing the chances of cancer development in humans.

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Antigenotoxic effect of nordihydroguaiaretic acid against chlormadinone acetate-induced genotoxicity in mice bone-marrow cells

Cited by 9 publications

References 30 publications

Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts

Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts

Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid

Effect ofCentella asiaticaL. extract against ethinylestradiol-induced geno-toxic damage on cultured human lymphocytes

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