Antigenicity of vascular heterografts

Pseudoaneurysm formation in a subset of patients with small intestinal submucosa biologic patches after carotid endarterectomy

“…23 The compliance values for the SIS grafts are only slightly less than those of canine femoral arteries and are much higher than those for Dacron (DuPont) and PTFE grafts, which should lead to less intimal hyperplasia, a finding that has been observed in experimental animal models. [6][7][8][9][10][11] The burst strength for small diameter SIS grafts far exceeds systolic blood pres-sure, attesting to its strength. 23 SIS grafts have been observed for up to 5 years in animals without evidence of aneurysm formation.…”

“…Complications associated with these patches include rupture and aneurysm formation for saphenous vein patches, infection and excessive bleeding for prosthetic patches, and aneurysmal dilatation of bovine pericardial patches. [6][7][8][9][10][11] The search for the Holy Grail in vascular graft material continues. Desirable attributes of an ideal graft material would include nonthrombogenicity, resistance to infection or aneurysm formation, excellent patency rates, and ready availability.…”