Antigen Barrier of the Mouse Placenta

Kirby, D. R. S.; Billington, W. D.; Bradbury, S.; Goldstein, D. J.

doi:10.1038/204548a0

Cited by 170 publications

(38 citation statements)

References 10 publications

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“…After 3-5 days in culture, the ectoplacental cone tissue has produced several layers of second¬ ary giant cells, the outermost of which express antigens. When secondary giant cells of the ecto¬ placental cone are first put into culture, antigens are presumably either absent (Simmons, Cruse & McKay, 1967) or masked, perhaps by a mucopolysaccharide (Kirby et al, 1964 (1972).…”

Section: Discussionmentioning

confidence: 99%

“…Their role is not fully understood ; it has been suggested that there is some non-cellular barrier associated with the trophoblast layers (Kirby, Billington, Bradbury & Goldstein, 1964;Currie & Bagshawe, 1967) which renders them antigenically inert. Experiments using neuraminidase-treated ectoplacental cone trophoblast (Currie, Van Doorninck & Bagshawe, 1968) supported this view, but Simmons, Lipschultz, Rios & Ray (1971) were unable to repeat these results.…”

Section: Introductionmentioning

confidence: 99%

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The expression of surface antigens on three trophoblastic tissues in the mouse

Carter¹

1978

Reproduction

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The expression of surface antigens on three trophoblastic tissues in the mouse

Carter¹

1978

Reproduction

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“…Indeed, there is much evidence to suggest that the success of the foetus is dependent on the characteristics of the trophoblast and it seems evident that trophoblast is relatively deficient in the expression of individual specific antigens (Bradbury et al, 1969;Currie and Bagshawe, 1967;Currie, van Doorninck and Bagshawe, 1968;Haskova, 1962;Kirby et al, 1964;Simmons and Russell, 1962). Now if the cellular reactions described above are an attempt at tumour rejection it might be expected that a marked reaction would be associated with a better response to treatment.…”

Section: Discussionmentioning

confidence: 99%

Cellular Reaction in Trophoblastic Tumours

Elston¹,

Bagshawe²

1973

Br J Cancer

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Summary.-The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a " severe " cellular reaction than in those with a " mild " reaction to gestational choriocarcinoma. The pathological and clinical features of invasive moles showed no relationship with the cellular reaction to the tumour. The cellular reaction to trophoblastic teratomata was generally poor but there was a marked cellular reaction to the tumour of one patient who has enjoyed a sustained remission.The relationship of cellular reaction and response to treatment with other histological and clinical features was examined. With the exception of a positive correlation between the degree of vascular invasion and response to treatment, none was found.It is suggested that an infiltrate of mononuclear cells in gestational choriocarcinoma is probably a response to the presence of tumour antigens. The infiltrate favourably affects the response to chemotherapeutic agents, suggesting that it contributes to tumour cell death and it may be interpreted as an immunological response directed at tumour rejection.

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“…IT has recently been suggested that the mucosubstances located at the cell surface may act in some way as a barrier to the detection of antigens by a host (Kirby et al, 1964;Currie, 1967;Lindenmann and Klein, 1967 Sanford, 1967;Bradbury et al, 1970); this may be termed the "antigen-masking" hypothesis. Support for this hypothesis comes both from studies of normal tissues, such as trophoblast (Kirby et al, 1964;Bradbury et at., 1965) as well as certain tumour cells, e.g.…”

mentioning

confidence: 99%

“…Support for this hypothesis comes both from studies of normal tissues, such as trophoblast (Kirby et al, 1964;Bradbury et at., 1965) as well as certain tumour cells, e.g. ascitic tumours in mice (Currie and Bagshawe, 1968;Bagshawe, 1969).…”

mentioning

confidence: 99%

Preliminary Observations on the Histochemistry of the Cell Surface of Carcinoma of the Cervix

Bradbury¹,

Wiernik²,

Williams³

et al. 1970

Br J Cancer

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Histochemical studies on the cell surface and intercellular matrix of normal cervical epithelium, and squamous cell carcinomata have shown the mucosubstances present may be symbolized by the descriptive formula: C(G) mucosubstance; B 3.5; A 2.5 (0.6m MgCl 2 ); T; S. This indicates that sulphate groups are absent and that the intercellular matrix and cell coat are rich in hyaluronic and sialic acids or closely related compounds. These may be important in masking the antigenic expression of the tumour cells. We have not been able to detect any alteration in the mucosubstances at 7 days following radium treatment. Images Figs. 1-3

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Antigen Barrier of the Mouse Placenta

Cited by 170 publications

References 10 publications

The expression of surface antigens on three trophoblastic tissues in the mouse

The expression of surface antigens on three trophoblastic tissues in the mouse

Cellular Reaction in Trophoblastic Tumours

Preliminary Observations on the Histochemistry of the Cell Surface of Carcinoma of the Cervix

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