The expression of surface antigens on three trophoblastic tissues in the mouse

Carter, Jan

doi:10.1530/jrf.0.0540433

Cited by 17 publications

(13 citation statements)

References 17 publications

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“…Increases in size and weight (Maroni & DeSousa, 1973;Beer, Scott & Billingham, 1975), lymphocyte accumulation and cellular proliferation (Ansell, McDougall, Speedy & Inchley, 1978) have been found in the lymph nodes draining the uterus during allogeneic pregnancy, although Hetherington & Humber (1977) could find no difference in weight changes during allogeneic or syngeneic pregnancies. Expression of allogeneic antigens on the feto-placental unit is well established (Simmons & Russell, 1966;Searle, Sellens, Elson, Jenkinson & Billington, 1976;Carter, 1976Carter, ,1978 and this would be consistent with the view that there is a response to fetal antigens in the para-aortic lymph nodes.…”

Section: Introductionsupporting

confidence: 81%

Changes in T and B lymphocyte populations in the lymph nodes draining the uterus in pregnant mice

Newport¹,

Carter²

1983

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Section: Introductionsupporting

confidence: 81%

Changes in T and B lymphocyte populations in the lymph nodes draining the uterus in pregnant mice

Newport¹,

Carter²

1983

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“…Primary and secondary giant trophoblast cells Details of trophoblast culture have been given elsewhere (Carter, 1978). Briefly, blastocysts were flushed from the uteri of Day-4 pregnant mice with phosphate-buffered saline (PBS), pH 7-3.…”

Section: Animals and Antiseramentioning

confidence: 99%

“…The test used was that of Fagraeus, Espmark & Jonsson (1965) and has been described in detail, with all specificity controls, elsewhere (Carter, 1978). Briefly, cultures of trophoblast cells were incubated for 1 h at 37°C with a 1:160 dilution of ScSn anti-CBA serum or a 1:40 dilution of CBA anti-ScSn serum.…”

Section: Mixed Haemadsorption Test and Preparation Of Indicator Cellsmentioning

confidence: 99%

“…4-0(5) 2-5 ± 0-5 (4) ' 3-91 ±008 (12) 2-08 + 0-37 (6) 0-01 ' 4-0(10) Effect of DON, glucosamine and glutamine on the development and antigen expression of ectoplacental cone outgrowths Ectoplacental cones cultured in 0-01, 0-1, 1, 10 or 20 pg DON/ml showed normal development for the first 24-48 h in culture. The tissue attached to the coverslip and giant cells outgrew (Carter, 1978). After 2-4 days the cells of outgrowths in 1, 10 or 20 pg DON/ml lost their ability to adhere both to each other and to the coverslip, and after 4 days in culture were dead.…”

Section: Effect Of Don On Blastocyst Development and Antigenic Expresmentioning

confidence: 99%

“…Secondary giant cells of the ectoplacental cone do not express antigens in vitro (Carter, 1978) until they have been in culture for approximately 4 days (Billington, Jenkinson, Searle & Sellens, 1977;Carter, 1978). H-2 antigens have been found on trophoblast cells in mice 14-18 days pregnant (Chatterjee-Hasrouni & Lala, 1979), which suggests that mechanisms other than an absence of transplantation antigens operate to protect the feto-placental unit.…”

Section: Introductionmentioning

confidence: 99%

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Detection of antigens on mouse giant trophoblast cells after incubation with an inhibitor of glycoprotein synthesis

Carter¹

1981

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The effect of 6-diazo-6-oxo-L-norleucine (DON), a glutamine analogue, on the development and expression of histocompatibility antigens on primary and secondary giant trophoblast cells has been examined in CBA and C57BL/10ScSn (ScSn) mice. Blastocyst development was normal in concentrations of less than 0.5 micrograms DON/ml, and although there was no change in the expression of antigenic determinants on CBA primary giant trophoblast cells, ScSn cells showed an increase. These strain-specific antigens which were not normally expressed on secondary giant trophoblast cells were detected on CBA and ScSn ectoplacental cone outgrowths after incubation with DON. The effect of DON could be reversed when tissue was incubated with DON + glutamine. Expression of Thy-1.2 antigen and Ig molecules on lymphocytes was unaffected by DON. It is suggested that the giant trophoblast cells of the ectoplacental cone produce a cell surface component which masks antigenic determinants and that there are differences in the amount of the masking agent produced by the primary giant trophoblast cells of the two strains of mouse.

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Giant and binucleate trophoblast cells of mammals

Hoffman

Wooding

1993

J. Exp. Zool.

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The cellular origin, structure, and function of trophoblastic giant cells (GC) and binucleate cells (BNC) are reviewed. Mammals in which these cells have received the greatest attention include rodents, rabbits, and humans (GCs), and ruminants and equids (BNCs). In almost all cases these cells arise from the cytotrophoblast. All are large cells and contain either two diploid nuclei (BNCs), multiple nuclei (human placental bed GCs), or single nuclei with amplified DNA content (rodent and rabbit GCs). Giant and binucleate cells typically exhibit the capacity for migration or invasion, although the degree of migratory activity varies between species. While most end up within, or at the interface with, endometrial tissue, in some instances the GCs or BNCs contribute directly to the interhemal membrane of the placenta. Hormone production is a property which most GC-BNC populations have in common. Lactogen or gonadotropin has been documented in almost all cells of this type examined to date, and in some animals they are also steroidogenic (e.g., rats and sheep). In spite of some common features, both structural and functional differences remain and it is suggested that use of terms such as mononuclear giant cells, multinucleate giant cells, and binucleate cells be continued rather than assuming that these cells are all members of a single trophoblastic subtype.

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The expression of surface antigens on three trophoblastic tissues in the mouse

Cited by 17 publications

References 17 publications

Changes in T and B lymphocyte populations in the lymph nodes draining the uterus in pregnant mice

Changes in T and B lymphocyte populations in the lymph nodes draining the uterus in pregnant mice

Detection of antigens on mouse giant trophoblast cells after incubation with an inhibitor of glycoprotein synthesis

Giant and binucleate trophoblast cells of mammals

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