Antifungal properties of Salvadora persica and Juglans regia L. extracts against oral Candida strains

Abstract

We report in this work, and for the first time, the potent antifungal activities of Salvadora persica and Juglans regia L. on different Candida species. Methanol, ethyl acetate, and diluted acetone extracts of S. persica (fresh and dry plant) and J. regia L. were screened for in vitro activity against some Candida species. These plants were selected due to their traditional use for the treatment of oral infections. Plant preparations were screened for antifungal activity using a standard agar disc diffusion assay. Following study of the antifungal activity of plant extracts, their minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values were determined using broth microdilution assay. Among S. persica and J. regia L. extracts, ethyl acetate J. regia L. extract had potent antifungal activity against all Candida strains. The MIC values of the J. regia L. against Candida strains ranged from 0.006 to 0.195 mg/ml. Two C. albicans strains showed a high MIC value (3.125 mg/ml). These results indicate that extracts can contain compounds with therapeutic potential against Candida strains and, hence, their possible use as therapeutic agents.

Inhibitory activity of Salvadora persica extracts against oral bacterial strains associated with periodontitis: An in-vitro study

“…21 However this slightly low pH could not possibly be the only factor for growth inhibition as a stronger acidic pH may cause complete inhibition. 22,23 In support of the present study, it has been shown that S. persica has significant antimicrobial activity against aerobic and anaerobic bacteria obtained from teeth with inflamed gums. 24 …”

Chemical Composition and Bioactivity of Salvadora persica Extracts against Some Potato Bacterial Pathogens

“…S. persica extract (20%) is effective as an antifungal and antibacterial agent against Candida albicans and Enterococcus faecalis (Al-Obaida et al 2010). The diluted acetone extract of dry stems (300 mg/mL) shows good inhibitory activity against C. albicans, C. glabrata, and C. parapsilosis strains with inhibition zones (IZs) that range from 10.33 mm to 15 mm (Noumi et al 2010).…”

Effect of Juglans regia Li. Stem Bark Hydroalcoholic Extract on Methicillin Resistant Staphylococcus aureus

“…Juglans regia stem bark contains chemical constituents, namely β-sitosterol, ascorbic acid5, juglone, folic acid, gallic acid, regiolone and quercetin-3-α-L-arabinoside (9). Antifungal, antibacterial and antioxidant activities of this plant have been studied by several researchers (15,16).…”