A novel and efficient method has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives using (N-isocyanimino)triphenylphosphorane, a secondary amine, a carboxylic acid, and an aromatic aldehyde in CH(2)Cl(2) at ambient temperature in high yields without using any catalyst or activation. The procedure provides an alternative method to the synthesis of fully substituted 1,3,4-oxadiazole derivatives.
Graphene-based materials are revealing
the leading edge of advanced
technology for their exceptional physical and chemical properties.
Chemical manipulation on graphene surface to tailor its unique properties
and modify atomic structures is being actively pursued. Therefore,
the discovery of robust and general protocols to anchor active functionality
on graphene basal plane is still of great interest. Multicomponent
reactions promise an enormous level of interest due to addressing
both diversity and complexity in combinatorial synthesis, in which
more than two starting compounds react to form a product derived from
entire inputs. In this article, we present the first covalent functionalization
route beginning with carboxylated-graphene oxide through Ugi four-component
assembly process (Ugi 4-CAP), in which amine, aldehyde, isocyanide,
and acid components come together in a one-pot reaction to generate
hydrophobic-, hydrophilic-, or amiphiphilic multifunctionalized graphene
composites. Investigation on the covalent immobilization and biocatalytic
activity of Bacillus thermocatenulatus lipase (BTL)
on graphene surface showed the efficiency and competency of Ugi 4-CAP.
The success of the multicomponent-coupling approach was confirmed
by atomic force microscopy, Raman spectroscopy, UV–vis spectroscopy,
Fourier transform infrared spectroscopy, 1H NMR, energy-dispersive
X-ray spectroscopy, scanning electron microscopy, thermogravimetric
analysis, and X-ray photoelectron spectroscopy.
An
ecofriendly inorganic–organic
hybrid and novel Schiff
base complex of copper coated on epoxy-modified Fe3O4@SiO2 MNPs was successfully designed and prepared
from readily available chemicals. In this method, a Schiff base complex
as a linker is utilized to protect copper nanoparticles to the core–shell
Fe3O4 exterior without agglomeration. The resulted
Schiff base complex of copper coated on epoxy-modified Fe3O4@SiO2 MNPs was characterized and confirmed
via different analyses such as FT-IR, TGA, XRD, VSM, FE-SEM, TEM,
ICP, EDX, and BET. The novel catalyst was examined for the synthesis
of various chromene-annulated heterocycles through the one-pot three
component reaction of aromatic aldehydes, various phenols (2-hydroxynaphthalene-1,4-dione/resorcinol/β-naphthol),
and malononitrile in ethanol at reflux conditions. This method includes
important aspects like no usage of column chromatography, very short
reaction times, simplicity of product isolation using ethanol, excellent
yields, simple procedures, and magnetic recoverability of the catalyst.
All in all, our method makes a novel and significant advancement in
the synthesis of various chromene-annulated heterocycles.
An efficient and heterogeneous novel
magnetic silica-coated picolylaminecopper
complex [Fe3O4@SiO2@GP/Picolylamine-Cu(II)]
was synthesized, characterized, and employed as a magnetically recoverable
nanocatalyst in Biginelli condensation for the preparation of biologically
active 3,4-dihydropyrimidinones. Fe3O4@SiO2@GP/Picolylamine-Cu(II) was synthesized easily using chemical
attachment of the picolylaminecompound on Fe3O4@SiO2@GP, followed by treatment with copper salt in ethanol
under reflux conditions. Fe3O4@SiO2@GP/Picolylamine-Cu(II) was affirmed by various analyses such as
Fourier transform infrared, thermogravimetric analysis, X-ray diffraction,
vibrating-sample magnetometry, field-emission scanning electron microscopy,
transmission electron microscopy, DLS, inductively coupled plasma,
energy-dispersive X-ray spectrometry, X-ray photoelectron spectroscopy,
and Brunauer–Emmett–Teller. The resulting catalyst system
was successfully used in the Biginelli reaction through a variety
of compounds such as aromatic aldehyde, urea, and ethyl acetoacetate
under solvent-free conditions or ethylene glycol at 80 °C and
yielded the desired products with high conversions with powerful reusability.
The current approach was convenient and clean, and only 0.01 g of
the catalyst could be used to perform the reaction. The easy work-up
procedure, gram-scale synthesis, usage of nontoxic solvent, improved
yield, short reaction times, and high durability of the catalyst are
several remarkable advantages of the current approach. Also, the Fe3O4@SiO2@GP/Picolylamine-Cu(II) nanocatalyst
could be recycled by an external magnet for eight runs with only a
significant loss in the product yields.
An effective heterogeneous nanocatalyst was successfully designed by immobilization of tungstate ions (WO 4 2− ) onto the modified surface of carbon quantum dots (CQDs) with the 1-aminopropyl-3-methyl-imidazolium chloride ([APMim][Cl]). In this work, for the first time, the synthesized CQDs@IL/Cl − , via a facile one-step hydrothermal method, was used as an adsorbent and stabilizing support for tungstate ions. Characterization of the synthesized nanoparticles (NPs) by various physicochemical techniques illustrated that tungstate ions have been immobilized on the surface of IL-modified CQDs. With this novel nanocatalyst, a variety of primary, secondary alcohols, and other alcohol substrates have been efficiently oxidized to their corresponding aldehydes and ketones in yields of ≥88% with high selectivity (100%). In the presence of CQDs@IL/WO 4 2− as a recyclable nanocatalyst, all alcohol substrates without overoxidation to carboxylic acid were oxidized within 2 h, under a temperature of 70 °C with H 2 O 2 as the oxidant. The above catalyst can be readily recycled using a simple extraction and reused consecutive runs under the described reaction conditions without a considerable decrease in the activity and selectivity. In conclusion, this Article offers a novel application for CQD chemistry.
Achieving
green and sustainable chemical processes by replacing
organic solvents with water has always been one of the green chemistry
goals and a challenging topic for chemists. However, the poor solubility
of organic materials is a major limitation to achieving this goal,
especially in alcohol oxidation. In this contribution, the development
and design of amphiphilic catalysts via abundant, safe, cheaper, and
more biocompatible sources have received notable attention. To this
purpose, herein, our group successfully synthesized a new multifunctional
amphiphilic carbon quantum dot (CQD) composed of 1-aminopropyl-3-methyl-imidazolium
chloride ([APMim][Cl]), dodecylamine (DDA), and citric acid (CA) (denoted
as CQDs@DDA-IL/Cl) using a one-pot hydrothermal route. The CQDs@DDA-IL/Cl
was then utilized as an amphiphilic stabilizer for anchoring tungsten
ions using an anion-exchange method (marked as CQDs@DDA-IL/W). The
CQDs@DDA-IL/W as a reusable catalyst selectivity mediated the oxidation
of alcoholic substrates with stoichiometric H2O2 in water solvent. The extraordinary performance of our catalyst
was attributable to the coexistence of ionic liquid (IL) and DDA upon
the surface of the CQDs@DDA-IL/W, which plays a main duty in the hydrophobic/hydrophilic
balance, and significantly increase the catalyst compatibility in
the aqueous medium with the purpose of removing organic solvents.
As a result, the great mass transfer occurs in the two-phase medium
using this amphiphilic nanocatalyst without any phase transfer catalyst
(PTC) or other additives. The 100% selectivity, excellent turnover
number (TON) and turnover frequency (TOF), high yield, almost complete
and fast conversion of alcohol to the desired aldehydes and ketones
without more oxidation, and easy and no-trouble isolation of product
and catalyst are outstanding features of this catalytic system.
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