Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles

Kamonkhantikul, Krid; Arksornnukit, Mansuang; Takahashi, Hidekazu

doi:10.2147/ijn.s132116

Cited by 48 publications

(35 citation statements)

References 29 publications

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“…The current results also disagree with a study carried out by Kamonkhantikul et al,12 who reported that the zinc oxide filler did not result in any improvement in the flexural strength of acrylic resins because of their shape (spherical), which evenly directed the stress throughout the resin matrix.…”

Section: Discussioncontrasting

confidence: 99%

Effect of the incorporation of zinc oxide nanoparticles on the flexural strength of auto- polymerized acrylic resins.

Kati

2019

J Oral Res

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Resumen: Antecedentes: Las resinas acrílicas autopolimerizadas se usan comúnmente en muchas aplicaciones en odontología, incluyendo la rehabilitación maxilofacial, en prótesis provisionales, reparación de prótesis, revestimientos, en aparatos de ortodoncia, bases de registro, entre otros. Estas sustancias, sin embargo, tienen algunos aspectos negativos tales como propiedades mecánicas deficientes. Objetivo: el objetivo del presente estudio fue evaluar el efecto de la incorporación de nanopartículas de óxido de zinc en la resistencia a la flexión de resinas acrílicas autopolimerizadas. Materiales y métodos: Treinta muestras de resinas acrílicas autopolimerizadas fueron hechas, divididas en tres grupos principales (un grupo control y dos experimentales), cada grupo con diez especímenes. Se incorporó polvo de óxido de zinc en los dos grupos experimentales, en concentraciones de 1% y 2%, respectivamente. Las muestras de acrílico se fabricaron con una dimensión de 65mm de longitud, 10mm de ancho y 2,5mm de espesor según la especificación ISO 1567 1999. Cada muestra se sometió a la prueba de resistencia a la flexión mediante una máquina de prueba universal. La velocidad de la cruceta para la prueba de resistencia a la flexión fue de 5mm/min hasta que se produjo la fractura. Se utilizó la versión SPSS 16 para el análisis estadístico. El ANOVA y Tukey se utilizaron para la comparación entre todos los grupos. Resultados: Se observó un aumento significativo (p<0.001

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Section: Discussioncontrasting

confidence: 99%

Effect of the incorporation of zinc oxide nanoparticles on the flexural strength of auto- polymerized acrylic resins.

Kati

2019

J Oral Res

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“…As evidenced in the previous publications [25,26,27], the fabrication of PMMA modified by ZnO NPs is possible in the conditions of an ordinary prosthetic laboratory. PMMA-ZnO composite materials with a filler in the form of nanometric ZnO particles (PMMA-ZnO nanocomposites [28,29]) as a promising material for denture bases are becoming increasingly more popular among scientists and dentists [25,26,27,30,31,32,33,34,35,36,37,38,39,40,41]. A thin layer of saliva is presenting the oral environment between the denture base and oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanoparticles Cytotoxicity and Release from Newly Formed PMMA–ZnO Nanocomposites Designed for Denture Bases

et al. 2019

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The goal of the study was to investigate the level of zinc oxide nanoparticles (ZnO NPs) release from polymethyl methacrylate (PMMA)–ZnO nanocomposites (2.5%, 5%, and 7.5% w/w), as well as from the ZnO NPs layer produced on pure PMMA, and the impact of the achieved final ZnO NPs concentration on cytotoxicity, before the potential use as an alternative material for denture bases. The concentration of ZnO nanoparticles released to the aqueous solution of Zn2+ ions was assessed using optical emission spectrometry with inductively coupled plasma (ICP-OES). In the control group (pure PMMA), the released mean for ZnO was 0.074 mg/L and for individual nanocomposites at concentrations of 2.5%, 5%, and 7.5% was 2.281 mg/L, 2.143 mg/L, and 3.512 mg/L, respectively. The median for the ZnO NPs layer produced on PMMA was 4.878 mg/L. In addition, in vitro cytotoxicity of ZnO NPs against the human HeLa cell line was determined through the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) dye. The cytotoxicity studies demonstrate that ZnO nanoparticles in the concentrations up to 20 mg/L have no adverse effect on HeLa cells. When compared with the released and cytotoxic concentrations of ZnO NPs, it can be expected that ZnO released from dental prostheses to the oral cavity environment will have no cytotoxic effect on host cells.

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“…Bone cements can also be enriched with the addition of metal nanoparticles, but so far the investigation of BC containing nanometals or their oxides are scarce. Several studies have been conducted with nanoTiO 2 , nanoMgO, nanoZnO, nanoAl 2 O 3 , nanoAg, and nanoAu to improve mechanical properties of implants or to obtain bactericidal activity but results are often inconclusive [37,38,39,40,41,42,43,44]. The selection of optimal BC modification is thus crucial to provide its safety, protection against infections and effective wound healing in patients [26,45].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration

et al. 2019

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Bacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin sulfate or nanometals: Silver or copper. The inhibition of bacterial adhesion and growth was examined against five different bacterial strains along with integrity of erythrocytes, viability of blood platelets, and dental pulp stem cells. Bone cement modified with nanoAg or nanoCu revealed greater bactericidal effects and prevented the biofilm formation better compared to antibiotic-loaded bone cement. The cement containing nanoAg displayed good cytocompatibility without noticeable hemolysis of erythrocytes or blood platelet disfunction and good viability of dental pulp stem cells (DPSC). On the contrary, the nanoCu cement enhanced hemolysis of erythrocytes, reduced the platelets aggregation, and decreased DPSC viability. Based on these studies, we suggest the modification of bone cement with nanoAg may be a good strategy to provide improved implant fixative for bone regeneration purposes.

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Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles

Cited by 48 publications

References 29 publications

Effect of the incorporation of zinc oxide nanoparticles on the flexural strength of auto- polymerized acrylic resins.

Effect of the incorporation of zinc oxide nanoparticles on the flexural strength of auto- polymerized acrylic resins.

Zinc Oxide Nanoparticles Cytotoxicity and Release from Newly Formed PMMA–ZnO Nanocomposites Designed for Denture Bases

Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration

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