Antifungal Diterpenoids and Flavonoids fromBallota inaequidens.

Antilisterial activity of ballota species growing in Turkey: Türkiye’de yetişen ballota türlerinin antilisteriyal aktivitesi

“…All the compounds tested had inhibitory activity against bacteria and showed good activities against C. albicans and C. crusei (25).…”

“…The main components of the Ballota species are flavonoids, labdane diterpenoids and phenylpropanoids (26). In our previous studies, three diterpenoids (hispanolone, ballonigrine, dehydrohispanolone) and ten flavonoids (kumatakenin, pachypodol, 5-hydroxy-7,3',4'-trimethoxyflavone, velutin, corymbosin, 5-hydroxy-3,7,4'-trimethoxyflavone, retusin, 5-hydroxy-7,4'-dimethoxyflavone, 5-hydroxy-3,6,7,4'-tetramethoxyflavone, ladanein) were isolated, chemically characterized and analysed by HPLC in different Ballota species (15,22,(25)(26)(27). This paper is a part of our on-going studies on this genus (15,(20)(21)(22)(23)(24)(25)(26)(27).…”

High performance liquid chromatographic analysis of some flavonoids of Ballota species

“…In our previous studies, three diterpenoids (hispanolone, ballonigrine, dehydrohispanolone) and ten flavonoids (kumatakenin, pachypodol, 5-hydroxy-7,3′,4′-trimethoxyflavone, velutin, corymbosine, 5-hydroxy-3,7,4′-trimethoxyflavone, retusin, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, ladanein) were isolated, chemically characterized, and analyzed by HPLC in different species of Ballota [6,7,13,14].…”

“…Ballota species have been used in Turkish folk medicine as an antiulcer, antispasmodic, diuretic, choleretic, antihaemorrhoidal, and sedative agents [2,3]. The antimicrobial activities [4] and the antioxidant activities [5] of all Ballota species growing in Turkey was recently reported as well as the antifungal activities of some flavonoids isolated from B. glandulossima [6] and B. inaequidens [7]. The water extract of B. glandulosissima has been reported to have antinociceptive [8], antiinflammatory, and hepatoprotective activities [9].…”

“…The antimicrobial activities [4] and the antioxidant activities [5] of all Ballota species growing in Turkey was recently reported as well as the antifungal activities of some flavonoids isolated from B. glandulossima [6] and B. inaequidens [7]. The water extract of B. glandulosissima has been reported to have antinociceptive [8], antiinflammatory, and hepatoprotective activities [9].Previous investigations of the aerial parts of the Ballota species resulted in the isolation of some flavonoids apigenin and apigenin-7-glucoside [10,11]; kumatakenin, ladanein [10]; genkwanin, nuchensin, isokaempferide, luteolin, luteolin-7-rutinoside, quercetin-3-glycoside, salvigenin, apigenin 6,8-di-C-glycoside [10]; luteolin-7-glycoside [10]; scutallerein-7,4′-dimethylether, acacetin-7-glycoside, chrysoeriol-7-glycoside [10], luteolin-7-lactate, and luteolin-7-glycosyl lactate [12].In our previous studies, three diterpenoids (hispanolone, ballonigrine, dehydrohispanolone) and ten flavonoids (kumatakenin, pachypodol, 5-hydroxy-7,3′,4′-trimethoxyflavone, velutin, corymbosine, 5-hydroxy-3,7,4′-trimethoxyflavone, retusin, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, ladanein) were isolated, chemically characterized, and analyzed by HPLC in different species of Ballota [6,7,13,14].Thus, as a continuation of our research [3-9, 13-15] on this genus we now report on the flavonoids present in the acetone extracts from sixteen species of the genus Ballota. Our aim is to contribute to their chemotaxonomic determination and establish the flavonoid profiles of Ballota species.…”