Antifungal and Surface Properties of Chitosan-Salts Modified PMMA Denture Base Material

Walczak, Katarzyna; Schierz, Georg; Basche, Sabine; Petto, Carola; Boening, Klaus; Więckiewicz, Mieszko

doi:10.3390/molecules25245899

Cited by 30 publications

(18 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, natural polymers have been attempted as novel methods to enhance the antimicrobial properties of dental appliances. For example, polymethyl methacrylate (PMMA) was modified with chitosan, a natural polymer with antibacterial and antifungal properties [47,48]. Nawasrah et al found that adding henna (Lawsonia inermis), an inexpensive natural extract that has antifungal propertie, to acrylic denture base material may control the proliferation of C. albicans [49].…”

Section: Discussionmentioning

confidence: 99%

Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

et al. 2022

View full text Add to dashboard Cite

Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminohexadecyl methacrylate (DMAHDM) into a high impact polymethylmethacrylate heat-cured denture base acrylic resin as a potential treatment for denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a protein repellent agent and DMAHDM as an antifungal agent to prevent the adherence of Candida albicans to the denture base material. The dual incorporation of MPC and DMAHDM reduced C. albicans biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture acrylic resin provides the benefit of enhancing C. albicans biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of denture stomatitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…On the other hand, Walczak et al (33) reported that, while chitosan salts had antifungal activity, adding chitosan salt powders to denture base materials had no antifungal, antibiofilm, or anti-adherent effects.…”

Section: Discussionmentioning

confidence: 99%

Mechanical Properties and Antifungal Activity of Ganoderma Lucidum Modified Polymethylmethacrylate: An In-vitro Study.

Enaba

Gendi

2022

Egyptian Dental Journal

View full text Add to dashboard Cite

Background: Polymethylmethacrylate (PMMA) is a common material used in dentistry. However, it has many deficiencies that could be addressed. Ganoderma Lucidum (G. Lucidum) material has a desirable antifungal effect and may also enhance the mechanical strength of PMMA materials.Objective: This study aimed to assess the flexural strength, modulus of elasticity and antifungal activity of the PMMA modified by G. Lucidum.Material and methods: Forty-eight specimens were prepared as two groups, group 1: PMMA (control), group 2: PMMA modified by G. Lucidum. Flexural strength and antifungal activity were assessed followed by scanning by confocal laser scanning microscopy (CFLSM). Modulus of elasticity was also calculated for both groups. Data were collected and statistically tested using oneway analysis of variance (ANOVA) to check the difference between studied groups then pairwise comparison by post-hoc test (Bonferroni's) was applied.Result: Group 2 showed higher flexural strength and modulus of elasticity (66.63155± 8.99886 MPa), (3243.82±732.2 MPa) respectively. Broth micro dilution assay of group 2 showed the microbial inhibited concentration (MIC) values were ≥ 375 μg/ml for Candida Albicans. This was also confirmed by the (CFLSM) by showing increased dead C. Albicans cells. Conclusion.It can be reported that the modification of PMMA with G. Lucidum can increase some mechanical properties and antifungal activity of the PMMA material.

show abstract

“…Modification of PMMA with chitosan was proposed by Walczak et al in order to achieve an antifungal effect. However, the results obtained are not satisfactory and require further investigation [ 80 ].…”

Section: Oral Applications Of Natural Polymersmentioning

confidence: 99%

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Paradowska-Stolarz

Więckiewicz

Owczarek

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all dental materials, polymers are a very important class with a wide spectrum of applications. This review aims to provide a state-of-the-art overview of the recent advances in the field of natural polymers used to maintain or restore oral health. It focuses on the properties of the most common proteins and polysaccharides of natural origin in terms of meeting the specific biological requirements in the increasingly demanding field of modern dentistry. The use of naturally derived polymers in different dental specialties for preventive and therapeutic purposes has been discussed. The major fields of application cover caries and the management of periodontal diseases, the fabrication of membranes and scaffolds for the regeneration of dental structures, the manufacturing of oral appliances and dentures as well as providing systems for oral drug delivery. This paper also includes a comparative characteristic of natural and synthetic dental polymers. Finally, the current review highlights new perspectives, possible future advancements, as well as challenges that may be encountered by researchers in the field of dental applications of polymers of natural origin.

show abstract

Antifungal and Surface Properties of Chitosan-Salts Modified PMMA Denture Base Material

Cited by 30 publications

References 51 publications

Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

Mechanical Properties and Antifungal Activity of Ganoderma Lucidum Modified Polymethylmethacrylate: An In-vitro Study.

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Contact Info

Product

Resources

About