Antifungal Activity of the Saponin Fraction Obtained from<i>Asparagus officinalis</i>L. and Its Active Principle

Shimoyamada, Makoto; Suzuki, Masayuki; Sonta, Hiromi; Maruyama, Makiko; Okubo, Kimihiro

doi:10.1080/00021369.1990.10870343

Cited by 6 publications

(13 citation statements)

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“…These two compounds were reported earlier from Dioscorea gracillima (16). This was the first report of their isolation from the genus Asparagus.…”

Section: Resultssupporting

confidence: 73%

“…In resent years, extracts of different parts of this plant have demonstrated antifungal (2), antimutagenic (3), diuretic (4), cytotoxic (5), antiviral (6), and molluscicide (7) properties. A considerable number of chemical constituents including flavonoids (8), oligosaccharides (9), amino acid derivatives (10), sulfurcontaining acids (11), and steroidal saponins (12)(13)(14)(15) have been isolated from the roots and shoots.…”

Section: Introductionmentioning

confidence: 99%

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Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic Activity

et al. 1997

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Two oligofurostanosides were isolated from the seeds of Asparagus officinalis L and their structures characterized as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-(alpha-L-rhamnopyranosyl- (1-->4))-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-(25R) -22 alpha-methoxyfurost-5-ene-3 beta,26-diol(methyl protodioscin) and its corresponding 22 alpha-hydroxy analogue (protodioscin). The structural identification was performed using detailed analysis of 1H- and 13C-NMR spectra including two-dimensional NMR spectroscopy (COSY, HMQC, NOESY and HMBC), and chemical conversions. These two compounds have been shown to inhibit the growth of human leukemia HL-60 cells in culture and macromolecular synthesis in a dose-dependent manner. The inhibitory effect on DNA synthesis was found to be irreversible.

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“…These two compounds were reported earlier from Dioscorea gracillima (16). This was the first report of their isolation from the genus Asparagus.…”

Section: Resultssupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic Activity

et al. 1997

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“…These include antimutagenic, antitumor, antifungal (Edenharder 1990, Shimoyamada et al 1990, Shao et al 1996, diuretic (Balansard & Rayband 1987) and immunostimulatory effects (Thatte & Dahanukar 1988, Rege et al 1999, Dhuley 1997. A. racemosus has been considered to be a lactogogue in lactational inadequacy (Sharma et al 1996) and useful to decrease post-operative adhesions (scars; Rege et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic β-cells

Hannan¹,

Marenah²,

Ali³

et al. 2007

Journal of Endocrinology

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Asparagus racemosus root has previously been reported to reduce blood glucose in rats and rabbits. In the present study, the effects of the ethanol extract and five partition fractions of the root of A. racemosus were evaluated on insulin secretion together with exploration of their mechanisms of action. The ethanol extract and each of the hexane, chloroform and ethyl acetate partition fractions concentration-dependently stimulated insulin secretion in isolated perfused rat pancreas, isolated rat islet cells and clonal b-cells. The stimulatory effects of the ethanol extract, hexane, chloroform and ethyl acetate partition fractions were potentiated by glucose, 3-isobutyl-1-methyl xanthine IBMX, tolbutamide and depolarizing concentration of KCl. Inhibition of A. racemosus-induced insulin release was observed with diazoxide and verapamil. Ethanol extract and five fractions increased intracellular Ca 2C , consistent with the observed abolition of insulin secretory effects under Ca 2C -free conditions. These findings reveal that constituents of A. racemosus root extracts have wide-ranging stimulatory effects on physiological insulinotropic pathways. Future work assessing the use of this plant as a source of active components may provide new opportunities for diabetes therapy.

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“…Asparanin A (1) was obtained as a white amorphous powder. The molecular formula was postulated as C 39 H 64 O 13 from the positive ion LRFABMS (m/z 763.2 [M + Na] + ) combined with 13 C NMR data. Acid hydrolysis of 1 gave only D-glucose as a sugar moiety.…”

mentioning

confidence: 99%

“…The 1 H and 13 C NMR data of 1 were identical to those of previously reported (25S*)-5β-spirostan-3β-ol-3-O-β-D-glucopyranosyl(1f2)-β-D-glucopyranoside. 2 The molecular formula of compound 2 (C 39 H 64 O 14 ) was determined on the basis of 13 C NMR and the HRFAB mass spectrum. The IR spectrum of 2 showed absorption for hydroxyl groups (3370 and 1070 cm -1 ) and characteristic absorption bands of a (25S*)-spirostanol steroidal type skeleton (982, 917, 896, and 850 cm -1 , intensity 917 > 896 cm -1 ).…”

mentioning

confidence: 99%

Cytotoxic Steroidal Saponins from the Rhizomes of Asparagus oligoclonos

Kim

Seong

et al. 2005

J. Nat. Prod.

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Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL.

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Antifungal Activity of the Saponin Fraction Obtained fromAsparagus officinalisL. and Its Active Principle

Cited by 6 publications

References 0 publications

Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic Activity

Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic Activity

Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic β-cells

Cytotoxic Steroidal Saponins from the Rhizomes of Asparagus oligoclonos

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