Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis

Couto, Fabíola Maria Marques do; Nascimento, Silène Carneiro do; Júnior, Silvio Francisco Pereira; Silva, Vanessa Karina Alves da; Leal, André Ferraz Goiana; Neves, Rejane Pereira

doi:10.1186/s40064-016-2130-8

Cited by 14 publications

(8 citation statements)

References 11 publications

(15 reference statements)

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“…Another nitrogen compound, piroctone olamine, reduces microbial colonization by inhibiting the growth of Malassezia spp. by showing antifungal activity [29]. e-CFR [30] reported the role of alcoholic and halogenated compounds in skincare products for cleaning and bacterial reduction application as antibacterial soap bars, antibacterial wipes, and disinfectants.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Fatty Acids, Polysaccharides, Amino Acids, and Minerals in Marine Macroalga Chaetomorpha crassa and Evaluation of Their Potentials in Skin Cosmetics

Kalasariya¹,

Patel²,

Yadav

et al. 2021

Molecules

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Cosmetic industries are highly committed to finding natural sources of functional active constituents preferable to safer materials to meet consumers’ demands. Marine macroalgae have diversified bioactive constituents and possess potential benefits in beauty care products. Hence, the present study was carried out to characterize the biochemical profile of marine macroalga Chaetomorpha crassa by using different techniques for revealing its cosmetic potentials. In results, the FTIR study characterized the presence of different bioactive functional groups that are responsible for many skin-beneficial compounds whereas six and fifteen different important phycocompounds were found in GCMS analysis of ethanolic and methanolic extracts, respectively. In the saccharide profile of C. crassa, a total of eight different carbohydrate derivatives were determined by the HRLCMS Q-TOF technique, which showed wide varieties of cosmetic interest. In ICP AES analysis, Si was found to be highest whereas Cu was found to be lowest among other elements. A total of twenty-one amino acids were measured by the HRLCMS-QTOF technique, which revealed the highest amount of the amino acid, Aspartic acid (1207.45 nmol/mL) and tyrosine (106.77 nmol/mL) was found to be the lowest in amount among other amino acids. Their cosmetic potentials have been studied based on previous research studies. The incorporation of seaweed-based bioactive components in cosmetics has been extensively growing due to its skin health-promoting effects.

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Section: Discussionmentioning

confidence: 99%

Characterization of Fatty Acids, Polysaccharides, Amino Acids, and Minerals in Marine Macroalga Chaetomorpha crassa and Evaluation of Their Potentials in Skin Cosmetics

Kalasariya¹,

Patel²,

Yadav

et al. 2021

Molecules

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“…Piroctone olamine is a common compound used in anti-dandruff shampoos for its anti-fungal properties. It exerts its effect via penetration of the cell membrane of the fungi, forming complexes with irons and inhibiting energy metabolism in mitochondria of the fungi [8]. Climbazole is an imidazole anti-fungal agent and exerts its anti-fungal effects by inhibiting the synthesis of ergosterol, a major component in fungal plasma membranes [9].…”

Section: Addressing a Clinical Needmentioning

confidence: 99%

Clinical efficacy of a gentle anti‐dandruff itch‐relieving shampoo formulation

Lim

Lim²,

Liang

2023

Intern J of Cosmetic Sci

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Dandruff is a common scalp condition affecting almost half of the world's population. Despite its high prevalence, the exact pathophysiology is not well established and is understood to be multifactorial, with factors such as fungal colonisation, sebaceous gland activity and individual factors being implicated. There is a need for an effective and safe shampoo that can target the above factors. Hence, we have developed a shampoo formulation with properties of oil control, moisturising, non‐irritative, anti‐fungal, anti‐microbial, and itch relieving.In this interventional, open‐label study, we evaluated the efficacy and safety of this shampoo in reducing the clinical signs of dandruff and pruritus in patients with pre‐existing mild to moderate dandruff over a course of 21‐day treatment duration through self‐assessment and objective clinical evaluations.After continued use of the shampoo, there was a significant decrease in the adherent and loose scalp flaking scores. Mean pruritus scores also decreased significantly across the 21‐day time points. There were also no adverse events or skin intolerances reported.This study showed that our shampoo formulation has led to significant reduction in both adherent and loose scalp flaking and pruritus when used in individuals suffering from mild to moderate dandruff. As such, it is an ideal shampoo which can be used to effectively control dandruff.

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“…In the case of piroctone olamine, is an antifungal compound with ability to reduce microbial colonization of Malassezia spp. [ 208 ]. It can penetrate the cell membrane and form complexes with iron (Fe 2+ and Fe 3+ ), by inhibiting energy metabolism in the mitochondria of target fungi [ 209 ].…”

Section: Synthetic Chemical Preservativesmentioning

confidence: 99%

Cosmetics Preservation: A Review on Present Strategies

et al. 2018

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Cosmetics, like any product containing water and organic/inorganic compounds, require preservation against microbial contamination to guarantee consumer’s safety and to increase their shelf-life. The microbiological safety has as main goal of consumer protection against potentially pathogenic microorganisms, together with the product’s preservation resulting from biological and physicochemical deterioration. This is ensured by chemical, physical, or physicochemical strategies. The most common strategy is based on the application of antimicrobial agents, either by using synthetic or natural compounds, or even multifunctional ingredients. Current validation of a preservation system follow the application of good manufacturing practices (GMPs), the control of the raw material, and the verification of the preservative effect by suitable methodologies, including the challenge test. Among the preservatives described in the positive lists of regulations, there are parabens, isothiasolinone, organic acids, formaldehyde releasers, triclosan, and chlorhexidine. These chemical agents have different mechanisms of antimicrobial action, depending on their chemical structure and functional group’s reactivity. Preservatives act on several cell targets; however, they might present toxic effects to the consumer. Indeed, their use at high concentrations is more effective from the preservation viewpoint being, however, toxic for the consumer, whereas at low concentrations microbial resistance can develop.

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Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis

Cited by 14 publications

References 11 publications

Characterization of Fatty Acids, Polysaccharides, Amino Acids, and Minerals in Marine Macroalga Chaetomorpha crassa and Evaluation of Their Potentials in Skin Cosmetics

Characterization of Fatty Acids, Polysaccharides, Amino Acids, and Minerals in Marine Macroalga Chaetomorpha crassa and Evaluation of Their Potentials in Skin Cosmetics

Clinical efficacy of a gentle anti‐dandruff itch‐relieving shampoo formulation

Cosmetics Preservation: A Review on Present Strategies

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