Antifungal Activity of Resveratrol Derivatives against <i>Candida</i> Species

Houillé, Benjamin; Papon, Nicolas; Boudesocque, Leslie; Bourdeaud, Eric; Besseau, Sébastien; Courdavault, Vincent; Enguehard‐Gueiffier, Cécile; Delanoue, Guillaume; Guérin, Laurence; Bouchara, Jean-Philippe; Clastre, Marc; Giglioli-Guivarc’h, Nathalie; Guillard, Jérôme; Lanoue, Arnaud

doi:10.1021/np5002576

Cited by 74 publications

(59 citation statements)

References 30 publications

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“…E-ε-Viniferin, Z/ E-vitisin B, ampelopsin A, and hopeaphenol were extracted from grape canes. 19 Acetonitrile and ethanol were purchased from Thermo Fisher …”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Biosynthetic Origin of E-Resveratrol Accumulation in Grape Canes during Postharvest Storage

Houillé

Besseau

Courdavault

et al. 2015

J. Agric. Food Chem.

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Grape canes are vineyard waste products containing valuable phytochemicals of medicine and agriculture interest. Grape canes storage is critical for the accumulation of these bioactive compounds. In the present study, we investigated the changes in stilbenoid phytochemical composition during grape cane storage and the influence of the temperature on final concentrations. A strong increase in the concentration of the monomer E-resveratrol (approximately 40-fold) was observed during the first 6 weeks of storage at 20 °C in eight different grape varieties without any change in oligomer concentrations. The E-resveratrol accumulation was temperature-dependent with an optimal range at 15-20 °C. A 2 h heat-shock treatment aiming at protein denaturation inhibited E-resveratrol accumulation. The constitutive expression of key genes involved in the stilbene precursor biosynthesis along with an induction of stilbene synthase (STS) expression during the first weeks of storage contribute to a de novo biosynthesis of E-resveratrol in pruned wood grapes.

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“…E-ε-Viniferin, Z/ E-vitisin B, ampelopsin A, and hopeaphenol were extracted from grape canes. 19 Acetonitrile and ethanol were purchased from Thermo Fisher …”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Biosynthetic Origin of E-Resveratrol Accumulation in Grape Canes during Postharvest Storage

Houillé

Besseau

Courdavault

et al. 2015

J. Agric. Food Chem.

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“…Stilbenoids (resveratrol and viniferin in particular) have reactive oxygen species (ROS) scavenging activity and act as a powerful defense system against biotic stresses (e.g., powdery mildew, downy mildew; Dabauza et al, 2015; Houillé et al, 2015). Furthermore, it is well-known that Vitis vinifera represents the best nutritional source of stilbenoid compounds with valuable effects on human health; these compounds have numerous pharmacological activities including anti-fungal, anti-inflammatory and anti-tumor effects (Bai et al, 2010; Zhang et al, 2010; Houillé et al, 2014). Constitutive stilbene production in plants and accumulation in the final product (berries and wines) depends on grape variety, climate, soil, and other factors (Vincenzi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Grapevine Grafting: Scion Transcript Profiling and Defense-Related Metabolites Induced by Rootstocks

et al. 2017

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Rootstocks are among the main factors that influence grape development as well as fruit and wine composition. In this work, rootstock/scion interactions were studied using transcriptomic and metabolic approaches on leaves of the “Gaglioppo” variety, grafted onto 13 different rootstocks growing in the same vineyard. The whole leaf transcriptome of “Gaglioppo” grafted onto five selected rootstocks showed high variability in gene expression. In particular, significant modulation of transcripts linked to primary and secondary metabolism was observed. Interestingly, genes and metabolites involved in defense responses (e.g., stilbenes and defense genes) were strongly activated particularly in the GAG-41B combination, characterized in addition by the down-regulation of abscisic acid (ABA) metabolism. On the contrary, the leaves of “Gaglioppo” grafted onto 1103 Paulsen showed an opposite regulations of those transcripts and metabolites, together with the greater sensitivity to downy mildew in a preliminary in vitro assay. This study carried out an extensive transcriptomic analysis of rootstock effects on scion leaves, helping to unravel this complex interaction, and suggesting an interesting correlation among constitutive stilbenes, ABA compound, and disease susceptibility to a fungal pathogen.

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“…3 Stilbenoids are valuable natural products due to their potential health benefit effects. These compounds exhibit numerous pharmacological activities including antidiabetic, 4 life-prolonging, 5 antifungal, 6 anti-inflammatory, 7 antitumoral, 8 antiatherogenic, 9 antiviral, 10 and neuroprotective effects. 11 In planta stilbenoids are both constitutive and inducible chemical defenses, and their levels in grape are associated with plant disease resistance.…”

Section: ■ Introductionmentioning

confidence: 99%

Composition and Tissue-Specific Distribution of Stilbenoids in Grape Canes Are Affected by Downy Mildew Pressure in the Vineyard

Houillé

Besseau

Delanoue

et al. 2015

J. Agric. Food Chem.

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Grape canes are byproducts of viticulture containing valuable bioactive stilbenoids including monomers and oligomers of E-resveratrol. Although effective contents in stilbenoids are known to be highly variable, the determining factors influencing this composition remain poorly understood. As stilbenoids are locally induced defense compounds in response to phytopathogens, this study assessed the impact of downy mildew infection during the growing season on the stilbenoid composition of winter-harvested grape canes. The spatial distribution between pith, conducting tissues, and cortex of E-piceatannol, E-resveratrol, E-ε-viniferin, ampelopsin A, E-miyabenol C, Z/E-vitisin B, hopeaphenol, and isohopeaphenol in grape canes from infected vineyards was strongly altered. In conducting tissues, representing the main site of stilbenoid accumulation, E-ε-viniferin content was higher and E-resveratrol content was lower. These findings suppose that the health status in vineyards could modify the composition of stilbenoids in winter-harvested grape canes and subsequently the potential biological properties of the valuable extracts.

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Antifungal Activity of Resveratrol Derivatives against Candida Species

Cited by 74 publications

References 30 publications

Biosynthetic Origin of E-Resveratrol Accumulation in Grape Canes during Postharvest Storage

Biosynthetic Origin of E-Resveratrol Accumulation in Grape Canes during Postharvest Storage

Grapevine Grafting: Scion Transcript Profiling and Defense-Related Metabolites Induced by Rootstocks

Composition and Tissue-Specific Distribution of Stilbenoids in Grape Canes Are Affected by Downy Mildew Pressure in the Vineyard

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