Antifungal Activity of Apple Cider Vinegar on <i>Candida</i> Species Involved in Denture Stomatitis

Mota, Ana Carolina Loureiro Gama; Oliveira, Julyana de Araújo; Lima, Edeltrudes de Oliveira

doi:10.1111/jopr.12207

Cited by 31 publications

(24 citation statements)

References 39 publications

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“…ACV also decreased blood triglyceride and very low density lipoprotein levels in rats which had induced cholesterol induced hepatic steatosis 33 . In an infection induced model of denture stomatitis, ACV addition resulted in anti-fungal activity against Candida Spp which was comparable to nystatin in terms of reducing microbial adherence and destruction 37 .…”

Section: Discussionmentioning

confidence: 94%

Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

Yagnik

Serafin

Shah

2018

Sci Rep

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The global escalation in antibiotic resistance cases means alternative antimicrobials are essential. The aim of this study was to investigate the antimicrobial capacity of apple cider vinegar (ACV) against E. coli, S. aureus and C. albicans. The minimum dilution of ACV required for growth inhibition varied for each microbial species. For C. albicans, a 1/2 ACV had the strongest effect, S. aureus, a 1/25 dilution ACV was required, whereas for E-coli cultures, a 1/50 ACV dilution was required (p < 0.05). Monocyte co-culture with microbes alongside ACV resulted in dose dependent downregulation of inflammatory cytokines (TNFα, IL-6). Results are expressed as percentage decreases in cytokine secretion comparing ACV treated with non-ACV treated monocytes cultured with E-coli (TNFα, 99.2%; IL-6, 98%), S. aureus (TNFα, 90%; IL-6, 83%) and C. albicans (TNFα, 83.3%; IL-6, 90.1%) respectively. Proteomic analyses of microbes demonstrated that ACV impaired cell integrity, organelles and protein expression. ACV treatment resulted in an absence in expression of DNA starvation protein, citrate synthase, isocitrate and malate dehydrogenases in E-coli; chaperone protein DNak and ftsz in S. aureus and pyruvate kinase, 6-phosphogluconate dehydrogenase, fructose bisphosphate were among the enzymes absent in C.albican cultures. The results demonstrate ACV has multiple antimicrobial potential with clinical therapeutic implications.

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Section: Discussionmentioning

confidence: 94%

Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

Yagnik

Serafin

Shah

2018

Sci Rep

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“…Recent clinical studies have revealed anti-biofilm efficacy of agents derived from plants [18][19][20][21], and importantly, an absence of detrimental effects on denture base materials [20,21]. Cinnamon oil is an extract from the plant Cinnamon cassia, whilst citronella is derived from Cymbopogon winterianus.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms

Almeida

Paula²,

Almeida³

et al. 2016

Acta Odontologica Scandinavica

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“…23 On the literature, it is noticed the great interest in new natural actives and herbal medicines, due its antimicrobial properties and/ or antiinflammatory, being, in the last years, many them reported. Among them, it can be found spread describe actives like vinegar from the apple, 25 black-pepper, 19 garlic, sage, mastic gum, 23 melaleuca, rosemary, citronella, 20 propolis and pomegranates. 26 As emphasis, it is the grape (Vitis vinifera).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antifungal Effect Vitis vinifera Extract on Candida albicans

Gadelha¹,

Valadas²,

Fiallos³

et al. 2018

JYP

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Objective: This research analyzed in vitro the antifungal activity of the solution composed by grapes seed extract Vitis vinifera (Doctor's A-Z®) against Candida albicans (ATCC 20231) species aiming to determine the minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC). Methods: To that, were used micro dilution boards of 96 wells where the strain of Candida. Was tested the diluted solutions in distilled water on the concentrations 0.20 g/mL, 0.30 g/mL and 0.40 g/mL. As growing control were used growing fungous, to test the viability of the strains. As positive control, was used nystatin (commercial suspension 100,000 UI/mL) and as sterility control of growing way. The tests were conducted in triplicate and the data obtained were analyzed through the exam Kruskal-Wallis, with significance level of 95% (p<0.05). Results: The results indicated that all the samples were sensible to the analyzed extract and the CIM was obtained with the solution of 0.30 g/mL (30%). However, wasn't observed a fungicide effect (MFC) on the tested concentrations. Conclusion: We conclude that the grapes seed extract can be an alternative against the gender Candida, however are necessary larger studies to prove their ant fungous action.

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Antifungal Activity of Apple Cider Vinegar on Candida Species Involved in Denture Stomatitis

Abstract: Apple cider vinegar showed antifungal properties against Candida spp., thus representing a possible therapeutic alternative for patients with denture stomatitis.

Cited by 31 publications

References 39 publications

Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms

Evaluation of the Antifungal Effect Vitis vinifera Extract on Candida albicans

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