Antifungal activities of the rhizome extract of five member Zingiberaceae against Candida albicans and Trichophyton rubrum

Abstract

Abstract. Prastiyanto ME, Rohmah N, Efendi L, Arifin R, Wardoyo FA, Wilson W, Mukaromah AH, Dewi SS, Darmawati S. 2021. Antifungal activities of the rhizome extract of five member Zingiberaceae against Candida albicans and Trichophyton rubrum. Biodiversitas 22: 1509-1513. Fungal infections have now become serious health issues. One of the strategies to avoid the problems of fungal infections is by using natural product from plants that are effective against many human pathogenic fungi. The study portrayed the use of the extracts of plant rhizomes as the alternatives to fight against number of human pathogenic fungi. This research aimed to investigate the antifungal activities of crude ethanol extract of five member of the family Zingiberaceae (Curcuma longa, Alpinia galanga Zingiber officinale. var. rubrum, Zingiber officinale var. officinarum and Zingiber officinale var. amarum), which are widely used as folk medicines against Candida albicans and Trichophyton rubrum. Crude ethanol extracts of five members of Zingiberaceae were evaluated for their antifungal activities and the results were calculated based on the zones of inhibition using the diffusion method. The extract showed antifungal activity against Candida. albicans in the agar well diffusion assay (10.2-27.1 mm inhibition diameter) and against T. rubrum (27.3-44.3 mm inhibition diameter). The data have revealed that all rhizomes have the potential to be developed as antifungal agents, particularly against C. albicans and T. rubrum. Studies on the antifungal activity against yeast-like (C. albicans) and filamentous (T. rubrum) can provide new information about the benefits of members Zingiberaceae as a source of natural antifungal. Researchers can select the type of rhizome that has more potential for further extraction to obtain pure compounds that can be used as antifungals.

Influence of Thermal Treatment on the Composition of Alpinia officinarum Rhizome

“…Many studies on the biological properties of Alpinia officinarum indicated its antioxidant [23,24], antiviral [25,26], antibacterial [27,28], antifungal [29,30], antimicrobial [31], analgesic and anti-inflammatory effects [32,33]. Aqueous extracts have also been studied in skin problems [34], showing antiphotoaging effects [35] and in studies on the pharmacological activity and therapeutic potential of galangin in age-related diseases [36].…”

hytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur

“…Beberapa di antaranya meliputi penelitian yang menggunakan ekstrak kulit biji cokelat terhadap jamur Trichophyton rubrum (Hutasoit et al, 2020), ekstrak kulit buah cokelat terhadap jamur Fusarium oxysporum (Rachmawaty et al, 2018), dan ekstrak daun cokelat terhadap jamur Candida albicans (Permataningrum et al, 2019), di mana ketiga penelitian ini membuktikan bahwa bagian tanaman Theobroma cacao yang dibuat sebagai ekstrak memiliki potensi sebagai antijamur. Candida albicans dan Trichophyton rubrum merupakan jamur Gram-positif (Prastiyanto et al, 2021)sama halnya dengan M. furfur.…”

Chemical Profiling, Antifungal and Anti-inflammatory Evaluations of Ethanol Extract of Zingiber officinale var. rubrum and Curcuma caesia Mixture from Riau, Sumatera Island, Indonesia

“…Fungal infections in human constitute a serious problem, especially in developing countries including Indonesia. 1 Fungal infections can result in inflammation, and each fungal species has a different response mechanism to evade the host immune system. 2,3 Inflammatory diseases are major health problem worldwide and can increase morbidity and mortality rates each year.…”