Antifertility activity of (zoapatle)

Montanoa frutescensandMontanoa grandifloraExtracts Reduce Anxiety-Like Behavior during the Metestrus-Diestrus Phase of the Ovarian Cycle in Wistar Rats

“…Montanoa plants and other Heliantheae plants contain terpenes with remarkable pleiotropic features. For example, ent-kaurenoic acid possesses both uterotonic and hypoglycemic activity [55]. We propose that the terpenes or flavonoids contained in Montanoa plants could be the active compounds involved in the anxiolytic-like effects reported herein by targeting the GABAergic system.…”

The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: Involvement of GABAA receptor

“…Early descriptions about the use of cihuapatli aqueous crude extract as a traditional remedy are contained in the Badianus Codex or Libellus de Medicinalibus Indorum Herbis written in 1552 (de la Cruz-Badiano, 1552), where botanical determinants, traditional recipes and prescriptions were provided. Mexican traditional medicine mentions that the prominent use of cihuapatli extract was as a contraceptive agent during the early stages of pregnancy (de la Cruz-Badiano, 1552;Ximenez, 1615;Hahn et al, 1981, Levine et al, 1981Gallegos, 1983;Ponce-Monter et al, 1983) and to induce rhythmic uterine contractions at birth. Additionally, mood and ''nervous'' disorders (an anxiety-like behavior in the context of Mexican antique culture) are also treated with the aqueous crude extract of cihuapatli and early reports by Ximenez (1615) mentioned, ''cihuapatli resolves the mood changes and nerves in an admirable form''.…”

Increase of the Ejaculatory Potency by the Systemic Administration of Aqueous Crude Extracts of Cihuapatli (Montanoa Genus) Plants in Spinal Male Rats

“…Cihuapatli extract was described as a remedy to favor parturition and during the puerperium but the outstanding use was as a contraceptive agent. [10][11][12] Experimental studies with laboratory animals have confirmed that plants included in the Montanoa genus prepared as aqueous crude extracts or its purified fractions have contraceptive effects that are provoked by inhibition of implantation, cervical dilatation, and uterine bleeding 7,[10][11][12] without influencing the endocrine status. Aqueous crude extracts of Cihuapatli plants do not modify the hematological, blood lipid, protein, and electrolytic status or the function of the liver, kidney, and thyroid gland.…”

“…Aqueous crude extracts of Cihuapatli plants do not modify the hematological, blood lipid, protein, and electrolytic status or the function of the liver, kidney, and thyroid gland. 10 A partial mechanism to describe the effects of the Cihuapatli aqueous crude extract on the female reproductive tract suggests an oxytocinergic profile exerted on the peripheral organs 8 and at the level of the central nervous system. 13,14 Recent studies reported that the extract of Cihuapatli prepared with Montanoa tomentosa can cross the blood-brain barrier to exert their actions directly on the central nervous system, 13,14 and in the case of copulating male rats, administration of this extract promotes an aphrodisiac effect by improving both sexual motivation and performance.…”

“…Cihuapatli extract was described as a remedy to favor parturition and during the puerperium but the outstanding use was as a contraceptive agent. 10–12…”