Antifatigue Effect of Luteolin‐6‐C‐Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

Duan, Fangfang; Guo, Ying; Li, Jing-wan; Yuan, Ke

doi:10.1155/2017/3159358

Cited by 48 publications

(31 citation statements)

References 65 publications

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“…This study shows a decrease in MDA levels, increased levels of endogenous antioxidants due to VCO administration were also reported by many researchers [28,[34][35][36][37] [38].…”

Section: Discussionsupporting

confidence: 87%

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Antioxidant and Hepatoprotective Effects of Virgin Coconut Oil at Maximum Physical Activity

Sinaga

Harahap

Silalahi

et al. 2019

Asian J Pharm Clin Res

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Objective: The purpose of this study was to determine the protective effects of virgin coconut oil (VCO) treatment on hepatic oxidative stress and antioxidant defenses after maximum physical activity. Methods: This study used 24 healthy male rats. The rats were divided into four groups randomly consisted of six rats in each group. The control group (P0) was given 2 mL water, the treatment groups (VCO-1, VCO-2, and VCO-4) were given VCO 1 ml/200 g BW, 2 ml/200 g BW, and 4 ml/200 g BW, respectively, per day using gavage spuit. The rats were trained to swim for a month, 30 min/day in the 1st week, 35 min/day in the 2nd week, 40 min/ day in the 3rd week, and 45 min/day in the 4th week. After 28 days, the rats were forced to perform the maximal activity by putting the rats in water with no exit. Blood samples were collected immediately after the maximum physical activity, and then, all rats were killed and liver tissues were collected. The malondialdehyde (MDA), glutathione peroxidase (GPx), and serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvate transaminase level were then measured. Results: VCO increased swimming time to exhaustion, levels of GPx in the liver, which were accompanied by corresponding decreases in the MDA, alanine transaminase, and aspartate transaminase content. Conclusion: The results from this study indicate that VCO is effective in the prevention of oxidative stress following maximum physical activity.

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“…This study shows a decrease in MDA levels, increased levels of endogenous antioxidants due to VCO administration were also reported by many researchers [28,[34][35][36][37] [38].…”

Section: Discussionsupporting

confidence: 87%

“…ALT and AST are a liver-specific enzyme. High levels of ALT and AST are indicative of liver injury [37,38].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Hepatoprotective Effects of Virgin Coconut Oil at Maximum Physical Activity

Sinaga

Harahap

Silalahi

et al. 2019

Asian J Pharm Clin Res

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“…Despite the hypothesized role of ROS in EIMD [14,15], the administration of N-acetylcysteine (a thiol-base antioxidant) may be counterproductive, as it has been associated with lower recovery of strength eight days after the exercise [16]. The protective effects of polyphenols after prolonged administration may depend more of the stimulation of the endogenous antioxidant systems through Nrf2 and antioxidant response element pathway signaling [44][45][46], rather than on a direct free radical-scavenging effect [2]. In the case of the combination of Zynamite ® with quercetin, the antioxidant/anti-inflammatory effect due to the inhibition of the ROS-producing enzymes XO and NADP oxidase may explain the effect observed even though only a single dose was administered before exercise.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise

et al. 2020

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Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.

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“…With ageing, fatigue prevalence increases for men and women and is related to adverse health outcomes, like morbidity and disability [3]. The WLFST is usually used to evaluate the anti-fatigue effect [38,39]. Thus, we utilized WLFST to observe the anti-fatigue effect of PAE.…”

Section: Discussionmentioning

confidence: 99%

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

Sun

et al. 2020

IJMS

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We aimed to study the effects of an ethyl acetate fraction of Physalis alkekengi (PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated β-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders.

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Antifatigue Effect of Luteolin‐6‐C‐Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

Cited by 48 publications

References 65 publications

Antioxidant and Hepatoprotective Effects of Virgin Coconut Oil at Maximum Physical Activity

Antioxidant and Hepatoprotective Effects of Virgin Coconut Oil at Maximum Physical Activity

Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise

Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

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