Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice

Tamboli, Abrar M; Rub, Rukhsana A.; Ghosh, Pranab; Bodhankar, Subhash L.

doi:10.1016/s2221-1691(12)60092-6

Cited by 48 publications

(25 citation statements)

References 18 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the samples reached equilibrium with the ambient temperature, excitation/emission spectra or intensity readings at 360-470 nm were recorded. 10 …”

Section: Serotonin Assaymentioning

confidence: 99%

Effect of nicotine on serotonin (5-HT) levels in brain of depressed rats

Bhalsinge

Barde

Worlikar

et al. 2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Reduction in brain serotonin (5-HT) levels contributes to depression. Nicotine may have antidepressant properties and smokers self-medicate underlying depression. Epidemiological findings suggest that smokers more often demonstrate depressive symptoms than non-smokers and depressed patients are less likely to cease smoking. Therefore, the study was planned to evaluate the effect of nicotine on serotonin levels in brain of depressed rats.Methods: Antidepressant action of study drugs was evaluated using isolation induced hyperactivity model in rats. Rats were divided into five groups with six rats in each group. Study groups: Vehicle in normal rats 1 ml/kg (subcutaneous); vehicle after isolation 1ml/kg (subcutaneous); imipramine 10 mg/kg (intraperitoneal) for 7 consecutive days; single dose of nicotine 0.4 mg/kg (subcutaneous); single dose of nicotine 0.2 mg/kg (inhalational). Brain serotonin assay was carried out. The statistical significance was determined by ANOVA followed by Tukey test (p<0.05).Results: Serotonin levels (55.93ng/g of brain tissue) in rats after isolation were significantly less than in normal rats (335.87ng/g) (p<0.001). In imipramine treated group, serotonin levels (301.4ng/g) after isolation were highly significant as compared to serotonin levels in vehicle treated group after isolation (p<0.001). Nicotine administered by subcutaneous and inhalational route showed significantly higher brain serotonin levels, i.e. 175ng/g and 254.62ng/g respectively as compared to vehicle treated rats after isolation (p<0.001).Conclusions: Single dose nicotine (inhalational) produced significant antidepressant action comparable to that of seven days’ treatment of standard antidepressant drug imipramine in rats. In rats, nicotine by both routes i.e. subcutaneous and inhalational increased serotonergic activity.

show abstract

“…After the samples reached equilibrium with the ambient temperature, excitation/emission spectra or intensity readings at 360-470 nm were recorded. 10 …”

Section: Serotonin Assaymentioning

confidence: 99%

Effect of nicotine on serotonin (5-HT) levels in brain of depressed rats

Bhalsinge

Barde

Worlikar

et al. 2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

show abstract

“…The ω6 / ω3 ratio within the range of 0.83-1.09. 15 The γ and δ tocopherols were the most important tocopherols, while the most representative phytosterols have been the β-sitosterol and stigmasterol. Furthermore, Sacha inchi oil contains unsaturated fatty acids such as linolenic acid (omega 3) (C18: 3), linoleic acid (omega 6) (C18: 2) and oleic acid (omega 9) (C18: 1).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy

Herrera-Calderon¹,

Yuli-Posadas²,

Tinco-Jayo³

et al. 2019

View full text Add to dashboard Cite

“…These phyto-constituents have variously been shown to be responsible for many bioactivities displayed by plants and new compounds can be discovered by probing them further. It must be noted however, that plant extract contains low concentrations of active compounds and a large number of promising compounds especially Lobelia species [17,18]. The essential oil analysis revealed the major compounds present in the Lobelia flaccida dried leaf to be acetophenone (26.37 %) caryophyllene (8.11 %), borneol (7.46 %) and anethole (6.81 %).…”

Section: Discussionmentioning

confidence: 99%

“…Biological studies on Lobelia species showed several activities including antimicrobial [15], antidepressant [16] anticancer [11] and antiepileptic [17] and analgesic and antivenom potentials [18].…”

Section: Introductionmentioning

confidence: 99%