Antidiarrhoeal effects of Mikania glomerata Spreng. (Asteraceae) leaf extract in mice

Abstract

Mikania glomerata Spreng. (Asteracae) is a plant widely used to treat gastrointestinal disorders in Brazilian traditional medicine. In the present work, an aqueous extract of the leaves of Mikania glomerata has shown a decrease in the propulsive movements of the intestinal contents in mice. Oral administration produced an inhibition of gastrointestinal transit as effective as that produced by loperamide. These fi ndings suggested that the aqueous extract of the leaves of Mikania glomerata might elicit an antidiarrhoeal effect by inhibiting intestinal motility.

Mikania glomerata Spreng: desenvolvimento de um produto fitoterápico

“…Um exemplo de sua importância foi a sua inclusão entre as plantas que compuseram a primeira edição da Farmacopéia Brasileira, já em 1929 (Dias da Silva, 1929;Brandão et al, 2006;2008). Outros trabalhos mostraram sua atividade anti-alergênica (Fierro et al, 1999), antimicrobiana (Pessini et al, 2003;Amaral et al, 2003;Santos et al, 2003;Duarte et al, 2004), além de atividade analgésica (Ruppelt et al, 1991), anti-infl amatória (Falcão et al, 2005), antioxidante (Vicentino et al, 2007) e anti diarréica (Salgado et al, 2005). O estudo fi toquímico dessa espécie resultou no isolamento dos ácidos ent- caur-16(17)-em-19-óico, ent-15-β-isobutiloxicaur-16(17)-em-19-óico, ent-15-β-benzoioxicaur-16(17)-en-19-óico, ent-15-β-hidroxicaur-16(17)-em-19-óico, ent-17-hidroxicaur-15(16)-em-19-óico, o-hidroxicinâmico, além das substâncias estigmasterol, friedelina, β-sitosterol, lupeol e cumarina (Santos et al, 1996;Taleb-Contini et al, 2006;Veneziani, 1997).…”

Antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba

“…of endogenous prostaglandin (Galvez et al, 1993). Loperamide, apart from regulating the gastrointestinal tract, is also reported to slow down transit in the small intestine, reduce colon fl ow rate, and consequently any effect on colonic motility (Theoderau et al, 1991;Salgado et al, 2005). In this study, the hydroethanolic extract of A. cadamba displayed a signifi cant and dose-dependent antidiarrhoeal property.…”

Natural Products fromGarcinia brasiliensisasLeishmaniaProtease Inhibitors

“…[17][18][19] The extract was dissolved in sterile water to a concentration of 60 mg/mL. Thirty adult female albino Swiss mice (Mus domesticus domesticus), weighing [24][25][26][27][28][29][30] .…”