Antidiarrhoeal activity of some Egyptian medicinal plant extracts

Atta, Attia H.; Mouneir, Samar M.

doi:10.1016/j.jep.2004.03.017

Cited by 136 publications

(77 citation statements)

References 10 publications

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“…Agrimonia eupatoria L. (Batanouny, 1999;Ghazanfar, 1994), and antidiarrheal (Atta and Mouneir, 2004) (Madari and Jacobs, 2004); treatment of disorders digestive (Asfi, 1994); constipation weak bowel actions (Zargari, 1994) 507…”

Section: Discussionmentioning

confidence: 99%

Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders

Bahmani

Zargaran

Rafieian-Kopaei

2014

Revista Brasileira de Farmacognosia

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Section: Discussionmentioning

confidence: 99%

Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders

Bahmani

Zargaran

Rafieian-Kopaei

2014

Revista Brasileira de Farmacognosia

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“…Diarrhea is one of the major health threats to populations in tropical and subtropical countries. It is responsible for about 5 million deaths annually, of which 2.5 million are children aged less than 5 years [2,3]. By definition, diarrhea is simply an altered movement of electrolytes and water through the intestinal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Implication of Oxidative Stress in Small Intestine Disorders, Constipation and Diarrhea: A Mini Review

Rtibi¹,

Amri²,

Sebaï³

et al. 2017

Recent Advances in Biology and Medicine

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Diarrhea pathophysiology and constipation are multifactorial gastrointestinal (GI) disorders characterized by intestinal peristalsis disruption of and an irregularity in secretion/absorption process. Oxidative stress, as an imbalance in prooxidants/antioxidants, has recently been recognized as a significant player in these GI disturbances. In this respect, numerous studies were performed and have shown that the deleterious effects on GI tract were accompanied by accumulation of oxidants and depletion of antioxidant system. Antioxidant remedy is necessary in scavenging free radicals and reactive oxygen species preventing oxidative stress-induced GI interruptions.

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“…Despite the availability of vast spectrum of approaches for diarrheal management, vast majority of people in developing countries rely on herbal drugs for the management of diarrhea. World Health Organization (WHO) has encouraged studies for treatment and prevention of diarrheal diseases depending on traditional medical practices (MaikereFaniyo et al 1989;Atta and Mouneir 2004). It is widely known that castor oil is metabolized into ricinoleic acid in the gut which is mainly responsible for diarrhea production (Ammon et al 1974).…”

Section: Discussionmentioning

confidence: 99%

Comparative study of antidiarrheal activity of methanol extracts from leaf and fruit of Pandanus odoratissimus Linn

Rahman

Islam

Barua

et al. 2014

Orient Pharm Exp Med

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Pandanus odoratissimus, a perennial, large shrub or small tree, has multifarious medicinal uses. The purpose of the present study was to evaluate the antidiarrheal effects of methanol extracts obtained from leaf and fruit of P. odoratissimus. The methanol extracts from the leaf and fruit of P. odoratissimus were evaluated for the antidiarrheal activity in rats. The effects of the extracts on defecation, intestinal transit and intestinal fluid accumulation (enteropooling) were assessed in castor oil-induced diarrhea. Oral administration of leaf and fruit extracts at 200 and 400 mg/kg exhibited significant (P<0.05-0.01) and dose-dependent antidiarrheal potential in castor oilinduced diarrhea. The diarrheal episode was inhibited by 34.30 % and 47.60 % by leaf extract, whereas 35.11 % and 47.15 % by fruit extract at the doses of 200 and 400 mg/kg respectively. The extracts were found to possess an antienteropooling in castor oil-induced experimental animals by reducing both weight and volume of intestinal content significantly and also decrease in intestinal transit comparable to that of standard drug, loperamide (5 mg/kg). These findings revealed that methanol extracts of leaf and fruit of P. odoratissimus possess significant antidiarrheal activities.

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Antidiarrhoeal activity of some Egyptian medicinal plant extracts

Cited by 136 publications

References 10 publications

Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders

Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders

Implication of Oxidative Stress in Small Intestine Disorders, Constipation and Diarrhea: A Mini Review

Comparative study of antidiarrheal activity of methanol extracts from leaf and fruit of Pandanus odoratissimus Linn

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